Alzheimer's disease - a neurospirochetosis.

The Journal of NeuroInflamation ^ | August 4, 2011 | By Judith Miklossy, MD

[Swordmaker]

Alzheimer's disease - a neurospirochetosis. Analysis of the evidence following Koch's and Hill's criteria.

Judith Miklossy
Correspondence: Judith Miklossy judithmiklossy@bluewin.ch

Journal of Neuroinflammation 2011, 8:90 doi:10.1186/1742-2094-8-90

Published: 4 August 2011
Abstract (provisional)

It is established that chronic spirochetal infection can cause slowly progressive dementia, brain atrophy and amyloid deposition in late neurosyphilis. Recently it has been suggested that various types of spirochetes, in an analogous way to Treponema pallidum, could cause dementia and may be involved in the pathogenesis of Alzheimer's disease (AD). Here, we review all data available in the literature on the detection of spirochetes in AD and critically analyze the association and causal relationship between spirochetes and AD following established criteria of Koch and Hill. The results show a statistically significant association between spirochetes and AD (P = 1.5 x 10-17, OR = 20, 95% CI = 8-60, N = 247). When neutral techniques recognizing all types of spirochetes were used, or the highly prevalent periodontal pathogen Treponemas were analyzed, spirochetes were observed in the brain in more than 90% of AD cases. Borrelia burgdorferi was detected in the brain in 25.3% of AD cases analyzed and was 13 times more frequent in AD compared to controls. Periodontal pathogen Treponemas (T. pectinovorum, T. amylovorum, T. lecithinolyticum, T. maltophilum, T. medium, T. socranskii) and Borrelia burgdorferi were detected using species specific PCR and antibodies. Importantly, co-infection with several spirochetes occurs in AD. The pathological and biological hallmarks of AD were reproduced in vitro. The analysis of reviewed data following Koch's and Hill's postulates shows a probable causal relationship between neurospirochetosis and AD. Persisting inflammation and amyloid deposition initiated and sustained by chronic spirochetal infection form together with the various hypotheses suggested to play a role in the pathogenesis of AD a comprehensive entity. As suggested by Hill, once the probability of a causal relationship is established prompt action is needed. Support and attention should be given to this field of AD research. Spirochetal infection occurs years or decades before the manifestation of dementia. As adequate antibiotic and anti-inflammatory therapies are available, as in syphilis, one might prevent and eradicate dementia.

The complete article is available as a provisional PDF. The fully formatted PDF and HTML versions are in production.

[Amntn]

Bump for later.

[SE Mom]

Bkmk and thanks. Got this link from the statin article.

[riri]

Bkmk

[Chgogal]

This is the Clorox Blue Cap you are talking about?

https://www.clorox.com/products/clorox-concentrated-regular-bleach/

[Chgogal]

This is the kind of Clorox I can get from my grocery:

https://www.doitbest.com/products/clorox-regular-concentrated-liquid-bleach?sku=600322&utm_source=shoppingfeeds&utm_medium=googlebase&utm_term=600322&utm_campaign=BROI&gdftrk=gdfV25409_a_7c1793_a_7c6797_a_7c600322&gclid=CK7H9ci8lsgCFZaHaQod_aIIUA

The label say New Concentrated?

[djf]

Thanks!

I have all my teeth - all four of them!

Seriously, most came out when I was about 53. My dad, who died at 50 from a massive heart attack, had none of his left at 45 or so.

None of us live forever. At least I haven’t discovered any evidence to the contrary.

Yet.

[going hot]

Well, I don’t know, you could still be doomed.

[djf]

It may be that xylitol is totally toxic to them. You can usually buy it at a health food store.

The reason is, it is a 5 carbon sugar that bugs love to ingest. But unfortunately, they don’t have the enzymes needed to break it down!

So they literally die stuffed to the gills!

But be VERY CAREFUL with xylitol. It is EXTREMELY toxic to dogs.

Cats I’m not sure about.

And just so you’re ok with it, humans have no problem.

[Swordmaker]

This is the Clorox Blue Cap you are talking about?

That's it. . . it's the basic plain Clorox™ which has NOTHING added to it. All other colors of caps have scents or other adulterations added that you don't want in your mouth.

[kalee]

For later

[Swordmaker]

PLEASE. IGNORE WHAT I JUST POSTED!

I just went to the Clorox™ website because I noticed the "concentrated" label on that bottle you linked to and it worried me. . . I wanted to check what the concentration of Sodium Hypochlorite was in their "concentrated" product. . . and to my horror I learned that Clorox has CHANGED their entire product line. . . and their cap coding too!!!!

OH, MY GOD! Clorox has just CHANGED all the formulas for CLOROX!!!!! They have tossed out the good old stand-by that has been a century old and replaced it with JUNK New formula with adulterations!!! They are also using the SAME COLOR CAP ON EVERY VARIETY!!!!!! They've thrown the baby out with the bathwater. I would NOT, REPEAT NOT!!! use any CLOROX product for hygienic use on the human body until further notice!!!!!

They do not make it easy to lean what the concentration is, but WORSE ALL of the Clorox products are now ADULTERATED with laundry additives. There IS no pure bleach Clorox anymore. For example their Regular Clorox now includes: "Sodium polyacrylate is used in laundry detergents to prevent soils from depositing on fabrics during the laundry cycle."

Another with the same blue cap, which just says "Clorox" but at the bottom lists "High Efficiency" also includes "Sodium Xylene Sulfanate"!

WHAT IN HELL ARE THEY THINKING!!!!

[Swordmaker]

Seriously, most came out when I was about 53. My dad, who died at 50 from a massive heart attack, had none of his left at 45 or so.

Well that's good news. The edentulous (those without teeth) cannot have bleeding gums where the teeth go through the gum line, because they don't have that interface. . . and they don't develop the problems we were seeing if they lost their teeth early enough. My father's mother had all her teeth pulled at age 17, because her doctor diagnosed her with what she always claimed was "Guitar of the Bowels" and had her teeth pulled as the proper treatment. I've never been able to find a disease to put to that name. . . in any case she died at 93, hale and hearty without any plaque related issues, mean and cantankerous as anyone I ever knew. Never had any false teeth either.

[Swordmaker]

It is toxic for Kittehs too.

[japaneseghost]

bump

[misanthrope]

Interesting read. Can’t believe I’ve not run across this thread before. Thanks Swordmaker.

[grey_whiskers]

Thanks for the word on xylitol. Note however, that I don’t own a dog, only a (very lazy) cat.

[JoeProBono]

[Chgogal]

Whoa! Boy I am so glad I double checked with you. Thanks so much!

In general things are going hooie here in the US. Remember when your good old Maytag would last 10-20 years? Well my 5 year old LG wash/dryer combo broke for the 2nd time in 1 month and Abt is making me wait 10 days before they are sending out a repair guy to order the parts. I require a washer/dryer combo because of space for width, height and venting.

Now good old Clorox changed its formula for the worse. GRRRRRRR!

What next?

: (

[Chgogal]

It looks like Clorox changed its formula due to environmental considerations. They also use 9/11 as an excuse but the changes did not occur until 2011.

http://pecancorner.blogspot.com/2014/03/why-bleach-does-not-work-as-well-anymore.html

[thesearethetimes...]

Bookmarking an awesome thread :)

Thanks to all.
Tatt