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Chokeberry extract found to regulate weight gain, blood glucose, and inflammation in rats
Federation of American Societies for Experimental Biology ^ | Apr 25, 2010 | Unknown

Posted on 04/25/2010 4:39:00 PM PDT by decimon

Chokeberry bushes have for centuries been residents of eastern deciduous forests where their bright red and dark purple fruits continue to be favorite snacks of local bird species. Native Americans have also traditionally eaten dried chokeberries and prepared teas from parts of the plant, and several domesticated varieties now grace contemporary lawns and gardens from coast to coast. However, the chokeberry (Aronia) is enjoying a new claim-to-fame as a potentially powerful antioxidant, and can now be found for sale in the dietary supplement and "health food" aisles of your local pharmacies and grocery stores.

What makes the humble chokeberry so healthful? Scientists think the answer lies in their unusually high levels of substances called anthocyanins (from the Greek anthos + kyanos meaning dark blue). There are many different anthocyanins in these colorful berries, but they all function as antioxidants – originally protecting the chokeberry seed from sunshine-induced oxidative stress. And when we eat them, they also appear to protect our bodies from a variety of damaging situations, including exposure to pollution and metabolically-derived free radicals. Indeed, a growing body of scientific literature has shown promising effects of chokeberry consumption on diseases ranging from cancer to obesity. These health-promoting effects may be due to the potent anti-inflammatory properties of anthocyanins, as uncontrolled inflammation is now universally recognized as a common thread in many of our most prevalent and deadly diseases. In addition, certain anthocyanins – including those found in chokeberry – have also been shown to improve blood sugar and the function of insulin.

To better understand how chokeberries influence health, Drs. Bolin Qin and Richard Anderson from the US Department of Agriculture in Beltsville, MD studied what happens when prediabetic rats are fed chokeberry extracts for an extended period of time. The results of their research will be presented on April 25 at the Experimental Biology 2010 meeting in Anaheim, CA. This presentation is part of the scientific program of the American Society for Nutrition, home of the world's leading nutrition researchers.

The researchers first made 18 male rats "prediabetic" or insulin insensitive by feeding them a fructose-rich diet for 6 weeks. Then they randomized the animals to continue drinking either pure water or water spiked with low or high levels of chokeberry extract (CellBerry®, Integrity Nutraceuticals International). After drinking this water for 6 weeks, the groups were compared in terms of body weight, body fat, blood glucose regulation, and molecular markers for inflammation.

Qin and Anderson found that at the end of the study the rats consuming the chokeberry-spiked water weighed less than the controls; both levels of chokeberry had the same effect in this regard. Similar beneficial effects of chokeberry consumption were found for body fat (specifically, that of the lower abdominal region). They also discovered that animals that had been drinking chokeberry extract had lower blood glucose and reduced levels of plasma triglycerides, cholesterol, and low-density lipoprotein (LDL) cholesterol when compared to the control animals. These alterations would theoretically lead to lower risk for diabetes and cardiovascular disease in humans. And to add even more evidence for a healthful impact of this super-berry, the researchers documented numerous alterations in expression of genes that would likely lead to reduced chronic inflammation and perhaps even lower cancer risk. For instance, drinking chokeberry extract lowered expression of the gene coding for interleukin-6 (IL-6), a protein that normally triggers inflammation following trauma or infection. Chronic overproduction of IL-6 has been documented in many diseases such as diabetes, arthritis, and atherosclerosis and is thought to be a partial cause of these conditions.

Of course, human studies will be needed before scientists can declare whether we derive the same health benefits from the chokeberry, but Qin and Anderson believe that their study "provides evidence that the chokeberry extract inhibits weight gain in insulin-resistant animals and that it modulates multiple genes associated with adipose tissue growth, blood glucose regulation, and inflammatory pathways." A final word to the wise: raw chokeberries are exceptionally bitter, so don't be tempted to harvest the shrubs in your backyard. Instead, look for this unassuming berry in fruit juice blends, jellies, and sweetened syrups.

###

Drs. Qin and Anderson are federal researchers in the Diet, Genomics, and Immunology Laboratory at the Beltsville Human Nutrition Research Center, a component of the US Department of Agriculture. This study was supported, in part, by Integrity Nutraceuticals International (South Spring Hill, TN).


TOPICS: Health/Medicine; Science
KEYWORDS: aronia; bloodglucose; chokeberry; diabetes; health; inflammation; medicine; weightcontrol
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1 posted on 04/25/2010 4:39:00 PM PDT by decimon
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To: neverdem; DvdMom; grey_whiskers

Bitter pill ping.


2 posted on 04/25/2010 4:40:01 PM PDT by decimon
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To: decimon

It’s the new and improved Montmorency Cherry that was all the rage last season! ;)


3 posted on 04/25/2010 4:41:24 PM PDT by Diana in Wisconsin (Save the Earth. It's the only planet with Chocolate.)
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To: decimon

How long till the Obama administration bans chokeberry?


4 posted on 04/25/2010 4:42:25 PM PDT by Paleo Conservative
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To: decimon

We will all be looking for natural remedies when 0care begins impacting us with doctor shortages.


5 posted on 04/25/2010 4:43:09 PM PDT by GailA (obamacare paid for by cuts & taxes on most vulnerable Veterans, retired Military, disabled & Seniors)
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To: decimon


6 posted on 04/25/2010 4:43:36 PM PDT by JoeProBono (A closed mouth gathers no feet)
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To: decimon
"...and it'll cure your asthma, too."

A great day for rats!

7 posted on 04/25/2010 4:43:57 PM PDT by the invisib1e hand (John Paulson is the new Michael Milken?)
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To: decimon
Wikipedia has pictures of chokeberry (aronia) bushes. Similar berries grow wild in my area but the birds do not eat them so I assume they are poisonous.
8 posted on 04/25/2010 4:45:27 PM PDT by decimon
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To: decimon

I’ll go for the wine....


9 posted on 04/25/2010 4:54:35 PM PDT by Sacajaweau (What)
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To: decimon

Now this wouldn’t be considered an advertisement, right?? And it won’t cure ya, right??


10 posted on 04/25/2010 4:55:47 PM PDT by Sacajaweau (What)
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To: Sacajaweau
And it won’t cure ya, right??

Cure ya? What is 'ya.' ;-)

I don't see any claim to any cure.

11 posted on 04/25/2010 5:05:23 PM PDT by decimon
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To: Sacajaweau

Brite future for skinny democRATs.


12 posted on 04/25/2010 5:08:09 PM PDT by Leo Carpathian (fffffFRrrreeeeepppeeee-ssed!)
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To: decimon

I would presume the birds don’t eat them because they’re bitter .. just as the research showed.

Birds like sweet berries.


13 posted on 04/25/2010 5:08:33 PM PDT by CyberAnt (HEALTHCARE IS NOT A "RIGHT"!!)
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To: CyberAnt

can humans eat anything birds eat,safely


14 posted on 04/25/2010 5:19:19 PM PDT by CGASMIA68
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To: decimon

None of my rats seem to be inflamed!


15 posted on 04/25/2010 5:24:29 PM PDT by SWAMPSNIPER (The Second Amendment, A Matter Of Fact, Not A Matter Of Opinion)
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To: decimon
Federation of American Societies for Experimental Biology

Any relation to the Federation of Planets?

16 posted on 04/25/2010 5:27:19 PM PDT by Moonman62 (The issue of whether cheap labor makes America great should have been settled by the Civil War.)
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To: CyberAnt
I would presume the birds don’t eat them because they’re bitter .. just as the research showed.

Birds like sweet berries.

According to the Wikipedia article, birds can't tell they are bitter: "The fruits are eaten by birds (birds do not taste astringency and feed on them readily), which then disperse the seeds in their droppings."

17 posted on 04/25/2010 5:28:15 PM PDT by decimon
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To: decimon; austinmark; FreedomCalls; IslandJeff; JRochelle; MarMema; Txsleuth; Newtoidaho; ...
FReepmail me if you want on or off the diabetes ping list.
18 posted on 04/25/2010 5:30:03 PM PDT by neverdem (Xin loi minh oi)
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To: JoeProBono

Is that where Obama gets his lip color?

19 posted on 04/25/2010 5:32:05 PM PDT by steve86 (Acerbic by nature, not nurture)
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To: decimon

Well .. you can rely on Wikipedia if you want, but they have a whole section on Statue of Limitations - looks like they left out a letter in the word Statute ..??

So .. I don’t rely on Wikipedia for ANY INFORMATION.


20 posted on 04/25/2010 5:34:20 PM PDT by CyberAnt (HEALTHCARE IS NOT A "RIGHT"!!)
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