Abstract Arterial calcification (AC) is generally regarded as an independent risk factor for cardiovascular morbidity and mortality. In rats, inactivation of MGP by treatment with the vitamin K antagonist warfarin leads to rapid calcification of the arteries. Both of the Vitamin K (VK)-rich diets decreased the arterial calcium content by some 50%. In addition, arterial distensibility was restored by the VK-rich diet. Using MGP antibodies, local VK deficiency was demonstrated at sites of calcification. This is the first study in rats demonstrating that AC and the resulting decreased arterial distensibility are reversible by high-VK intake. Introduction Arterial calcification is an...