Chronic liver damage can lead to hepatitis, which causes fibrosis of the liver. This buildup of collagen and other fibrous tissue accelerates when hepatic stellate cells become activated during hepatitis, often resulting in liver cancer or cirrhosis, both of which can be fatal. As there are no effective drugs to treat cirrhosis, suppressing the activation of the stellate cells is considered as a way of controlling the progression of liver fibrosis. "It is estimated that one out of every three to four people worldwide have steatotic liver disease, when there is an abnormal accumulation of lipids, which is a precursor...