Mouse pancreas cells with high levels of the protein SRSF1; CSHL Professor Adrian Krainer found that mice with high levels of SRFS1 tend to exhibit intraepithelial neoplasia—a known precursor to the most common form of pancreatic cancer. Credit: Krainer lab/Cold Spring Harbor Laboratory Researchers at the Cold Spring Harbor Laboratory found that the protein SRSF1, which regulates RNA splicing, plays a critical role in the development of pancreatic ductal adenocarcinoma (PDAC), a deadly form of pancreatic cancer. Elevated levels of SRSF1 lead to inflammation and stimulate tumor growth, while restoring normal levels halts the disease’s progress. This discovery could pave...