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A research team is the first to reveal that a molecule in the brain—ophthalmic acid—unexpectedly acts like a neurotransmitter similar to dopamine in regulating motor function, offering a new therapeutic target for Parkinson's. The researchers observed that ophthalmic acid binds to and activates calcium-sensing receptors in the brain, reversing the movement impairments of Parkinson's mouse models for more than 20 hours. The disabling neurogenerative disease affects millions worldwide over the age of 50. L-dopa, the front-line drug for treatment, acts by replacing the lost dopamine and has a duration of two to three hours. While initially successful, the effect of...

Researchers have developed a method to recreate the formation of Lewy bodies in human neurons, shedding light on the essential roles of alpha-synuclein and immune responses in their development. This breakthrough offers new insights into Parkinson’s disease, showing that Lewy bodies form only under specific conditions and highlighting the potential for new treatment avenues. Lewy bodies are a key feature of Parkinson’s disease (PD) and other related neurological disorders. Unraveling their development is essential for improving treatments. Researchers at The Neuro (Montreal Neurological Institute-Hospital) of McGill University, in collaboration with its Early Drug Discovery Unit, have successfully replicated the formation...

An enzyme called PGK1 has an unexpectedly critical role in the production of chemical energy in brain cells, according to a preclinical study. The investigators found that boosting its activity may help the brain resist the energy deficits that can lead to Parkinson's disease. The study presented evidence that PGK1 is a "rate-limiting" enzyme in energy production in the output-signaling branches, or axons, of the dopamine neurons that are affected in Parkinson's disease. This means that even a modest boost to PGK1 activity can have an outsized effect on restoring the neuronal energy supply in low-fuel conditions—and the researchers showed...

Parkinson's disease is a neurodegenerative disease caused by the loss of neurons that produce dopamine, a neurotransmitter involved in motor control and cognitive function. As the global population ages, the number of Parkinson's disease patients is rapidly increasing. Parkinson's disease is induced by neuronal damage due to excessive production of reactive oxygen species. Suppression of reactive oxygen species generation is essential because it is fatal to dopaminergic neurons that manage dopamine neurotransmitters. Currently, only symptomatic treatment is available, so the development of treatment regimens and prevention methods is necessary. Associate Professor Akiko Kojima-Yuasa led a research group that has verified...

Joe Biden sat down for an interview with Black Entertainment Television (BET) host Ed Gordon to pander to black voters. Joe “you ain’t black” Biden is struggling with black voters as the 2024 election cycle goes into full swing. Meanwhile, President Trump is making inroads with blacks. Biden’s interview with BET was a pathetic attempt to appeal to black voters. Biden rambled incoherently as he lied about his involvement in the civil rights movement. This is one of Biden’s favorite lies (he has many). “I got involved in the civil rights movement [unintelligible].” At this point, Biden mumbled through a...

VIDEOS AT LINK......................... People have been saying it’s Parkinson’s for some time now. Alex Berenson: Following my post today, a neurosurgeon and Unreported Truths reader (yes, some of you are actually brain surgeons) wrote in. For obvious reasons, he did not want his name used, but his email and answers to my follow-up question speak for itself. I’d urge you to read to the end, for the prediction he makes. I simply wanted to give you a thumbs up on your diagnosis of POTUS. He undoubtedly has Parkinson’s disease, and is increasingly suffering from Parkinson’s dementia. The signs are unmistakable:...

Video interview from NBC Tom Llamas with Dr. Tom Pitts, Neurologist.

The White House was forced to make yet another embarrassing clarification after Press Secretary Karine Jean-Pierre told reporters that a meeting between the president's personal physician and a neurological specialist was not related to Joe Biden's personal care. In fact, it was part of Biden's annual physical, as she later had to admit. It is the most recent gaffe by officials as the nation's oldest president fights for his political life amid questions about his fitness for the job.

President Joe Biden is slated to participate in a one-on-one interview with NBC’s Lester Holt, as the 81 year old continues to stand defiantly in his decision to remain in the presidential race, despite the pleas of some very well-known Democrats. NBC’s Monica Alba announced the upcoming interview, writing on X, “BREAKING: @NBCNews anchor Lester Holt will sit down with President Biden for an exclusive one-on-one interview on Monday in Austin, Texas.” The entire interview is expected to air during a primetime special at 9:00 p.m. Eastern that same day. BREAKING: @NBCNews anchor Lester Holt will sit down with President...

After reports surfaced on Monday that a neurologist specializing in Parkinson's disease made repeated visits to the White House in recent months, the Biden administration offered an explanation late Monday. The explanation comes as President Joe Biden faces continued questions on his mental acuity as several Democratic lawmakers have called on the president to exit the 2024 presidential race. In a letter from Dr. Kevin O'Connor, who serves as the physician to the president, he said neurologist Dr. Kevin Cannard made numerous visits to the White House campus in his capacity in the White House Medical Unit. O'Connor said many...

WASHINGTON (Reuters) - U.S. President Joe Biden is not being treated for Parkinson's disease, the White House said on Monday, after reports surfaced that a doctor specializing in the malady had visited the White House eight times over the past year.Concerns that the president might be suffering from an undisclosed illness have risen since Biden's stumbled in his June 27 debate with Republican Donald Trump.The New York Times said White House visitor logs show that Dr. Kevin Cannard, a neurologist who specializes in movement disorders and recently published a paper on Parkinson’s, visited the White House eight times from last...

Joe Biden’s physician Dr. O’Connor on Monday evening offered an explanation for the Parkinson’s disease expert’s numerous visits to the White House this year. A Parkinson’s disease specialist visited the White House TEN TIMES going back to November 2022 according to visitor logs. The Parkinson’s expert visited the White House 8 times in 8 months! Monday’s press briefing devolved into chaos as Karine Jean-Pierre repeatedly declined to say why a Parkinson’s disease expert visited the White House so many times this year. Parkinson’s disease (PD) is a brain disorder that causes progressive issues with movement, mental health, sleep, and pain....

For years now, honest voices on the right have called out Joe Biden's various "senior moments" and raised questions about his physical and cognitive health. While the signs of dementia have been obvious for a while now, it was only after Biden's performance at the debate that voices on the left finally admitted that something is wrong with Joe Biden. But has the White House been covering up more than just dementia? Visitor logs obtained by the New York Post reveal that President Joe Biden's primary physician repeatedly consulted with a Parkinson's disease specialist at the White House. According to...

The President's personal physician and a nurse who coordinates his care scheduled the meetings with Dr. Kevin R. Cannard. Before last July, he had come only once during Joe Biden's administration. Dr. Kevin R. Cannard, a Parkinson’s disease specialist, has visited the White House at least nine times in the last year, official White House visitor logs show. The logs show Dr. Cannard traveled to the White House residence medical clinic each time. He met either with the president’s personal physician or the naval nurse who coordinates care for the president and other top officials, the logs show. Dr. Cannard’s...

The President's personal physician and a nurse who coordinates his care scheduled the meetings with Dr. Kevin R. Cannard. Before last July, he had come only once during Joe Biden's administration. Dr. Kevin R. Cannard, a Parkinson’s disease specialist, has visited the White House at least nine times in the last year, official White House visitor logs show. The logs show Dr. Cannard traveled to the White House residence medical clinic each time. He met either with the president’s personal physician or the naval nurse who coordinates care for the president and other top officials, the logs show. Dr. Cannard’s...

A top Washington D.C. neurologist had a meeting with President Biden’s personal doctor at the White House earlier this year, visitor logs reviewed by The Post show. Dr. Kevin Cannard, a Parkinson’s disease expert at Walter Reed Medical Center, met with Dr. Kevin O’Connor, and two others at the White House residence clinic on Jan. 17, according to the records, which emerge as questions continue to swirl about the 81-year-old president’s mental health in the wake of his debate debacle last week with former President Trump. Dr. John E. Atwood, a cardiologist are Walter Reed, was also in the 5...

President Biden on call with staff just now: “Let me say this as clearly as I possibly can, as simply and straightforward as I can: I am running." "No one is pushing me out.” "I'm not leaving. I'm in this race to the end and we're going to win." ..... Snip..... In the same call, vice-president Kamala Harris – whose name has been increasingly floated around as Biden’s replacement – continued to voice her support for Biden, with reports of her saying: We will not back down. We will follow our president’s lead. We will fight and we will win....

Following my post today, a neurosurgeon and Unreported Truths reader (yes, some of you are actually brain surgeons) wrote in. For obvious reasons, he did not want his name used, but his email and answers to my follow-up question speak for itself. I’d urge you to read to the end, for the prediction he makes. I simply wanted to give you a thumbs up on your diagnosis of POTUS. He undoubtedly has Parkinson’s disease, and is increasingly suffering from Parkinson’s dementia. The signs are unmistakable: -his shuffling gait -the absence of associated movements (facial expression, arm swinging). When he does...

Neurodegenerative diseases (NDDs) result in irreversible damage to the brain and nervous system. Research into these diseases typically focuses on the brain, but mouse studies from the last few years suggest that the microbiome plays a role in the onset and progression of some NDDs, as well. Those researchers report a new link in humans between a metabolite produced by gut microbes and three NDDs. Their analysis suggests that the metabolite DHPS (2,3-dihydroxypropane-1-sulfonate) may help answer critical questions about how sulfur metabolism pathways can connect the microbiome to these diseases. DHPS has not previously been detected in people, and the...

A new study suggests that certain drugs commonly used to treat enlarged prostate may also decrease the risk for dementia with Lewy bodies (DLB). This observational finding may seem surprising, but it mirrors previous work that links the drugs to a protective effect in another neurodegenerative condition—Parkinson's disease. The researchers think that a specific side effect of the drugs targets a biological flaw shared by DLB and Parkinson's disease, as well as other neurodegenerative diseases, raising the possibility that they may have broad potential for treating a wide range of neurodegenerative conditions. The researchers used a large database of patient...