Researchers have unveiled crucial insights into the factors that might influence Intervertebral Disk Degeneration (IDD). IDD is a predominant cause of lower back pain, impacting millions worldwide. The focus of this research revolved around nucleus pulposus cells (NPCs), pivotal in IDD, and how oxygen levels and the HIF1A gene could influence them. Employing advanced RNA sequencing (RNA-seq), the team meticulously captured a comprehensive transcriptome of NPCs exposed to different oxygen conditions and instances of HIF1A deletion. The study leveraged tissues sourced from patients who had given informed consent before undergoing surgery. The efficacy of HIF1A modifications was authenticated using q-PCR,...