On Monday, the Food and Drug Administration granted full approval to the Pfizer-BioNTech vaccine for the coronavirus, and approvals for the Moderna and Johnson & Johnson vaccines could follow soon. This could be a significant step in convincing the millions of unvaccinated Americans to finally get vaccinated, even if it doesn’t quickly transform the state of the pandemic. It’s also an opportunity for us to say to the hard-core vaccine refusers: We’re done with you.