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Chicago hospital treating severe Covid-19 patients with Gilead Sciences’ antiviral medicine remdesivir in a closely watched clinical trial is seeing rapid recoveries in fever and respiratory symptoms, with nearly all patients discharged in less than a week, STAT has learned. Remdesivir was one of the first medicines identified as having the potential to impact SARS-CoV-2, the novel coronavirus that causes Covid-19, in lab tests. The entire world has been waiting for results from Gilead’s clinical trials, and positive results would likely lead to fast approvals by the Food and Drug Administration and other regulatory agencies. If safe and effective, it...

Another study conducted by researchers at the University of Utah found that “critically ill patients with lung injury requiring mechanical ventilation may benefit from administration of ivermectin,” ABC News reported. “We noted a lower mortality and reduced health care resource use in those treated with ivermectin,” wrote lead author Dr. Amit Patel. And at Broward Health Medical Center in Florida, Dr. Jean-Jacques Rajter has already been using ivermectin in addition to hydroxychloroquine, azithromycin and zinc sulfate to treat his COVID-19 patients, according to NBC Miami. “If we get to these people early, and what I mean by that is if...

Slated for human trials, EIDD-2801 could become the first pill for COVID-19An oral medicine was able to hinder the coronavirus behind COVID-19 as it attempted to replicate itself in human lung cells in test tubes, scientists reported Monday. It also hampered closely related coronaviruses from reproducing in mice for several days and improved their lung functions.* The drug, called EIDD-2801, interferes with a key mechanism that allows the SARS-CoV-2 virus to reproduce in high numbers and cause infections, the researchers explained in the journal Science Translational Medicine. Human trials have not yet been done, but if the effect is similar...

A microbiologist in Germany believes that the use of an updated version of a 100-year-old Tuberculosis vaccine may work as an intermediate treatment for Covid-19. CNN's Frederik Pleitgen reports.

Abstract Although several clinical trials are now underway to test possible therapies, the worldwide response to the COVID-19 outbreak has been largely limited to monitoring/containment. We report here that Ivermectin, an FDA-approved anti-parasitic previously shown to have broad-spectrum anti-viral activity in vitro, is an inhibitor of the causative virus (SARS-CoV-2), with a single addition to Vero-hSLAM cells 2 hours post infection with SARS-CoV-2 able to effect ∼5000-fold reduction in viral RNA at 48 h. Ivermectin therefore warrants further investigation for possible benefits in humans. Ivermectin is an FDA-approved broad spectrum anti-parasitic agent1 that in recent years we, along with other...

https://www.sciencedirect.com/science/article/pii/S0166354220302011 The FDA-approved Drug Ivermectin inhibits the replication of SARS-CoV-2 in vitro Highlights • Ivermectin is an inhibitor of the COVID-19 causative virus (SARS-CoV-2) in vitro. • A single treatment able to effect ∼5000-fold reduction in virus at 48h in cell culture. • Ivermectin is FDA-approved for parasitic infections, and therefore has a potential for repurposing. • Ivermectin is widely available, due to its inclusion on the WHO model list of essential medicines. Abstract Although several clinical trials are now underway to test possible therapies, the worldwide response to the COVID-19 outbreak has been largely limited to monitoring/containment. We report...

An experimental HIV drug that has been used to successfully treat COVID-19 patients is in its second phase of testing with the Food and Drug Administration and could potentially be approved for use in four weeks, its manufacturer says. Leronlimab, made by the biotech company CytoDyn, was used to treat a handful of severely ill patients in New York City hospitals; a couple were able to be removed from their ventilators.

The push in the U.S. pandemic epicenter follows the president’s declaration that he ‘feels good’ about compounds with unproven efficacy, hydroxychloroquine and chloroquine. New York is moving at unprecedented speed and scale in a human experiment to distribute tens of thousands of doses of anti-malarial drugs to seriously ill patients, spurred by political leaders including President Trump to try a treatment that is not proved to be effective against the coronavirus. With no proven treatment for the coronavirus, and infections in New York topping 30,000, health experts say the Food and Drug Administration has moved with uncommon speed to authorize...

Amid a barrage of research on finding treatment for new coronavirus, Australian scientists have found that a common anti-parasitic drug killed SARS-CoV-2 virus, growing in cell culture, within 48 hours in lab settings. Ivermectin is an FDA-approved anti-parasitic drug that has also been shown to be effective in vitro against a broad range of viruses including HIV, dengue, influenza and Zika virus. Published in the journal Antiviral Research, the study from Monash University showed that a single dose of Ivermectin could stop the coronavirus growing in cell culture -- effectively eradicating all genetic material of the virus within two days....

Researchers in Australia report that Ivermectin, an FDA-approved drug commonly used to treat parasites, appears to be effective in treating the SARS-COV-2 coronavirus (COVID-19). The drug is widely available and can be “repurposed” for this application, doctors said. The ScienceDirect journal, Antiviral Research, published an article by a group of Australian researchers from Monash University in Melbourne reporting that Ivermectin appears to be effective at inhibiting the coronavirus that causes COVID-19. The article states: Ivermectin is an inhibitor of the COVID-19 causative virus (SARS-CoV-2) in vitro. A single treatment able to effect ∼5000-fold reduction in virus at 48h in cell...

An anti-parasitic head lice drug available around the world has been found to kill COVID-19 in the lab within 48 hours. A Monash University-led study has shown a single dose of the drug Ivermectin could stop the SARS-CoV-2 virus growing in cell culture. 'We found that even a single dose could essentially remove all viral RNA (effectively removed all genetic material of the virus) by 48 hours and that even at 24 hours there was a really significant reduction in it,' Monash Biomedicine Discovery Institute's Dr Kylie Wagstaff said on Friday. While it's not known how Ivermectin works on the...

Researchers have identified dozens of drugs and compounds, some experimental and others already approved by health authorities, that may be effective in combating the CCP virus. The Epoch Times refers to the novel coronavirus, also called SARS-CoV-2, as the CCP virus because the Chinese Communist Party’s coverup and mishandling allowed the virus to spread throughout China and spark a global pandemic. In a preprint study not yet peer-reviewed, published on March 22 on bioRxiv, the research team indicated it found hundreds of “high confidence” interactions between SARS-CoV-2 virus proteins and druggable human proteins. Nearly 70 substances, including both drugs in...

PUTRAJAYA: The anti-malarial drug chloroquine has shown its efficacy in the treatment of Covid-19 patients since the first wave of the outbreak in Malaysia, the director-general of health, Dr Noor Hisham Abdullah, said. He said the drugs’ anti-inflammatory properties were effective in treating Covid-19 which causes inflammation of the lower respiratory tract. Noor Hisham said a similar anti-malarial drug hydroxychloroquine and a combination of antiviral drugs lopinavir and ritonavir had also been used in the treatment of patients in Malaysia. There had been promising results but further research was still required. Noor Hisham said the number of deaths from Covid-19...

For the past two weeks now, we’ve been talking about hydroxychloroquine as the wonder drug in the fight against the deadly coronavirus. Two anti-malaria drugs hydroxychloroquine and chloroquine are shown to be effective in treating COVID-19 patients after controlled clinical study conducted by doctors ​in France shows that a combo of Hydroxychloroquine and Azithromycin (Z-Pak) cures 100% of coronavirus patients within 6 days of treatment. However, according to doctors treating coronovirus patients in Italy, Tolicizumab, a drug used to treat moderate to severe rheumatoid arthritis, has been shown to be more effective than hydroxychloroquine. Tolicizumab is so effective that the...

A healthcare AI company has spotted several unexpected, off-label drug combinations that may do the job against COVID-19. In any case, the company is offering its complete AI toolkit free of charge to drug developers working on COVID treatments. In announcing its work, Germany-based Innoplexus, which specializes in AI-based drug discovery and development, says the promising combos emerged from its processing of hundreds of studies covering thousands of patients. Most of the findings mentioned in the announcement involve the potential of the decades-old, much-discussed malaria fighter Hydroxychloroquine as used with other drugs. For example, the analysis showed that combining Chloroquine...

A Florida man diagnosed with coronavirus claims he was saved from certain death by an anti-malaria drug touted as a possible treatment by President Trump. Rio Giardinieri, 52, told Los Angeles’ Fox 11 that he struggled with horrendous back pain, headaches, cough and fatigue for five days after catching COVID-19, possibly at a conference in New York.

Margaret Novins talked to me on her cellphone from a hospital bed at CentraState Medical Center in Freehold, N.J. She had been ill since March 8, toughing it out through fatigue, a cough and fevers that brought on vicious chills for five evenings straight. Finally, on March 15, she went to an urgent care center and, on March 16, to an emergency room. The attending there called it “conversational dyspnea.” “I couldn’t breathe,” she said. Novins, who shared her lab tests and medication list, got her diagnosis March 19. Next to the entry for SARS-CoV-2 were the words “Detected Critical.”...

It’s human nature during one of the bleakest moments in American history to lunge at promising news about drug treatments. We’d probably be in the midst of a public uproar about chloroquine even if Trump had never mentioned it; the encouraging anecdotal reports from China and France about its effect on coronavirus were destined to go viral among frightened people even if they weren’t mentioned by big fish like Tucker Carlson and small fish like me. We need hope.But we also need perspective. The chloroquine hype comes at a cost, potentially. And that cost will be terrible if the...

The Mylan plant in Morgantown, West Virginia will restart production of hydroxychloroquine this week. The drug was touted by researchers, doctors and President Trump in the treatment of the COVID-19 virus.

[Editor's note: Lack of FDA approval does not prohibit off-label use of drugs for other threapeutic purposes, but would inhibit widespred use.] You are being lied to about the drugs that heal COVID19. America's FDA, and National Institute of Allergy and Infectious Diseases Director Dr. Anthony Fauci, are dragging their feet on approving a drug that provides very strong positive effect on COVID19. Fauci, speaking from the White House, said on the matter of approving Hydroxychloroquine and azithromycin: