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Inflammatory signaling blocks NUMB’s ability to deaden NOTCH1-driven tumor developmentHOUSTON — An inflammation-promoting protein triggers deactivation of a tumor-suppressor that usually blocks cancer formation via the NOTCH signaling pathway, a team of researchers led by scientists at The University of Texas MD Anderson Cancer Center reports today in Molecular Cell. Working in liver cancer cell lines, the team discovered a mechanism by which tumor necrosis factor alpha (TNFα) stimulates tumor formation, said senior author Mien-Chie Hung, Ph.D., professor and chair of MD Anderson's Department of Molecular and Cellular Oncology. Hung also is MD Anderson's vice president for basic research. "We've...

Circulation: active ingredient sildenafil makes stiffened cardiac walls elastic againHow sildenafil, the active ingredient in Viagra, can alleviate heart problems is reported by Bochum's researchers in cooperation with colleagues from the Mayo Clinic in Rochester (Minnesota) in the journal Circulation. They studied dogs with diastolic heart failure, a condition in which the heart chamber does not sufficiently fill with blood. The scientists showed that sildenafil makes stiffened cardiac walls more elastic again. The drug activates an enzyme that causes the giant protein titin in the myocardial cells to relax. "We have developed a therapy in an animal model that, for...

An article to be published Friday (Dec. 23) in the December 2011 issue of The Quarterly Review of Biology argues that multiple sclerosis, long viewed as primarily an autoimmune disease, is not actually a disease of the immune system. Dr. Angelique Corthals, a forensic anthropologist and professor at the John Jay College of Criminal Justice in New York, suggests instead that MS is caused by faulty lipid metabolism, in many ways more similar to coronary atherosclerosis (hardening of the arteries) than to other autoimmune diseases. Framing MS as a metabolic disorder helps to explain many puzzling aspects of the disease,...

Sometimes it's nice to remember that older people have always been shocked by the habits of the young. One hundred years ago, in 1911, Tilden Pierce turned 100 years old and talked to the New York Times (not the Onion) about why he didn't think the younger generation would be able to achieve his longevity: too much pie and too many baths. "Yep," he told the Times from his Plymouth, Mass., old folks' home. "What's shortening the days of the present generation is because they eat too much pie and cake."

A great explosive burning of coal set fire and made molten by lava bubbling from the Earth's mantle , looking akin to Kuwait's giant oil fires but lasting anywhere from centuries to millennia, could have been the cause of the world's most-devastating mass extinction, new research suggests. The event, called the Great Dying, occurred 250 million years ago, at the end of the Permian period. "The Great Dying was the biggest of all the mass extinctions," said study researcher Darcy Ogden of the Scripps Institution of Oceanography in San Diego. "Estimates suggest up to 96 percent of all marine species...

A compound produced from fish oil that appears to target leukemia stem cells could lead to a cure for the disease, according to Penn State researchers. The compound -- delta-12-protaglandin J3, or D12-PGJ3 -- targeted and killed the stem cells of chronic myelogenous leukemia, or CML, in mice, said Sandeep Prabhu, associate professor of immunology and molecular toxicology in the Department of Veterinary and Medical Sciences. The compound is produced from EPA -- Eicosapentaenoic Acid -- an Omega-3 fatty acid found in fish and in fish oil, he said. "Research in the past on fatty acids has shown the health...

World leaders probably spent more time worrying about the eurozone crisis than anything else in 2011. And that was in the year that featured the Arab Spring, the Japanese tsunami and the death of Osama Bin Laden. What's more, 2012 looks set to be not much different. But as eurozone governments hammer out new rules to limit their borrowing, are they missing the point of the crisis?

Scientists at the University of Granada have shown that oleic acid and hydroxytyrosol –present in a particularly high concentration in virgin olive oil– and n-3 polyunsaturated fatty acids –found in fish– relieve the symptoms of pancreatitis. The researchers evaluated the role of Mediterranean diet ingredients in the prevention and mitigation of cell damage. Oleic acid and hydroxytyrosol –present in a particularly high concentration in virgin olive oil– and n-3 polyunsaturated fatty acids –found in fish– affect the cellular mechanisms involved in the development of acute pancreatitis, a disease of oxidative-inflammatory etiology. Therefore, oleic acid and hydroxytyrosol can be considered...

Exposure to sunlight may help impede the spread of chickenpox, claim researchers.The University of London team found chickenpox less common in regions with high UV levels, reports the journal Virology. Sunlight may inactivate viruses on the skin, making it harder to pass on. However, other experts say that other factors, including temperature, humidity, and even living conditions are equally likely to play a role. The varicella-zoster virus is highly contagious, while it can be spread through the coughs and sneezes in the early stages of the infection, the main source is contact with the trademark rash of blisters and spots....

NEW YORK (Reuters Health) - Extra vitamin D and calcium may offer some protection against fractures in elderly people, but have little or no impact on cancer risk, according to a fresh look at the medical evidence. Some research has suggested that vitamin D, with or without calcium, might help stave off cancer, but recent trials have slashed those hopes. "It turns out that as a group, all of the micronutrient supplements have been disappointing," said Dr. Michael Pollak, who heads the division of cancer prevention at McGill University in Montreal, Canada, and was not involved in the new work....

A study examining the prevalence of the fungus Fusarium in bathroom sink drains suggests that plumbing systems may be a common source of human infections. In the first extensive survey of its kind, researchers in Penn State's College of Agricultural Sciences sampled nearly 500 sink drains from 131 buildings -- businesses, homes, university dormitories and public facilities -- in Pennsylvania, Maryland, Virginia, North Carolina, South Carolina, Georgia, Florida and California. They analyzed fungal DNA to compare the spectrum of Fusarium species and sequence types found in drains with those recovered from human infections. The study identified at least one Fusarium...

It is vital that the body's own immune system does not overreact. If its key players, the helper T cells, get out of control, this can lead to autoimmune diseases or allergies. An immune system overreaction against infectious agents may even directly damage organs and tissues. Immune cells called regulatory T cells ("Tregs") ensure that immune responses take place in a coordinated manner: They downregulate the dividing activity of helper T cells and reduce their production of immune mediators. "This happens through direct contact between regulatory cell and helper cell," says Prof. Peter Krammer of DKFZ. "But we didn't know...

Beer tested in a new study, including some brands labeled "low-gluten," contains levels of hordein, the form of gluten present in barley, that could cause symptoms in patients with celiac disease (CD), the autoimmune condition treated with a life-long gluten-free diet, scientists are reporting. The study, which weighs in on a controversy over the gluten content of beer, appears in ACS' Journal of Proteome Research. > As expected, their analysis of 60 commercial beers found that eight labeled "gluten-free" did not contain gluten. But many regular, commercial beers had significant levels of gluten. Most surprising, two beers labeled as "low-gluten"...

Bacteria living in people's large intestine may slow down the activity of the "good" kind of fat tissue, a special fat that quickly burns calories and may help prevent obesity, scientists are reporting in a new study. The discovery, published in ACS' Journal of Proteome Research, could shed light on ways to prevent obesity and promote weight loss, including possible microbial and pharmaceutical approaches, the authors said. Sandrine P. Claus, Jeremy K. Nicholson and colleagues explain that trillions of bacteria live in the large intestine of healthy people, where they help digest food and make certain vitamins. In recent years,...

Thousands of Iranian Jews and their descendants owe their lives to a Muslim diplomat in wartime Paris, according to a new book. In The Lion's Shadow tells how Abdol-Hossein Sardari risked everything to help fellow Iranians escape the Nazis.Eliane Senahi Cohanim was seven years old when she fled France with her family. She remembers clutching her favourite doll and lying as still as she could, pretending to be asleep, whenever their train came to a halt at a Nazi checkpoint. "I remember everywhere, when we were running away, they would ask for our passports, and I remember my father would...

Keep going, doc. I think you’re on to something: U.S. Senator Tom Coburn, M.D. (R-OK) today released a new oversight report, “Wastebook 2011″ that highlights over $6.5 billion in examples of some of the most egregious ways your taxpayer dollars were wasted. This report details 100 of the countless unnecessary, duplicative and low-priority projects spread throughout the federal government. “Video games, robot dragons, Christmas trees, and magic museums. This is not a Christmas wish list, these are just some of the ways the federal government spent your tax dollars. Over the past 12 months, politicians argued, debated and lamented about...

WEST LAFAYETTE, Ind. - Bacteria are able to build camouflaged homes for themselves inside healthy cells - and cause disease - by manipulating a natural cellular process. Purdue University biologists led a team that revealed how a pair of proteins from the bacteria Legionella pneumophila, which causes Legionnaires disease, alters a host protein in order to divert raw materials within the cell for use in building and disguising a large structure that houses the bacteria as it replicates. Zhao-Qing Luo, the associate professor of biological sciences who headed the study, said the modification of the host protein creates a dam,...

Researchers with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab), through a combination of time-lapse live imaging and mathematical modeling of a special line of human breast cells, have found evidence to suggest that for low dose levels of ionizing radiation, cancer risks may not be directly proportional to dose. This contradicts the standard model for predicting biological damage from ionizing radiation – the linear-no-threshold hypothesis or LNT – which holds that risk is directly proportional to dose at all levels of irradiation. “Our data show that at lower doses of ionizing radiation, DNA repair mechanisms...

More evidence emerges to support that the progenitor of syphilis came from the New WorldSkeletons don't lie. But sometimes they may mislead, as in the case of bones that reputedly showed evidence of syphilis in Europe and other parts of the Old World before Christopher Columbus made his historic voyage in 1492. None of this skeletal evidence, including 54 published reports, holds up when subjected to standardized analyses for both diagnosis and dating, according to an appraisal in the current Yearbook of Physical Anthropology. In fact, the skeletal data bolsters the case that syphilis did not exist in Europe before...

Scientists studying a unique collection of human skulls have shown that changes to the skull shape thought to have occurred independently through separate evolutionary events may have actually precipitated each other. Researchers at the Universities of Manchester and Barcelona examined 390 skulls from the Austrian town of Hallstatt and found evidence that the human skull is highly integrated, meaning variation in one part of the skull is linked to changes throughout the skull. The Austrian skulls are part of a famous collection kept in the Hallstatt Catholic Church ossuary; local tradition dictates that the remains of the town's dead are...