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Viagra against heart failure: Researchers at the RUB and from Rochester throw light on the mechanism
Ruhr-University Bochum ^ | December 23, 2011

Posted on 12/23/2011 7:49:52 AM PST by decimon

Circulation: active ingredient sildenafil makes stiffened cardiac walls elastic again

How sildenafil, the active ingredient in Viagra, can alleviate heart problems is reported by Bochum's researchers in cooperation with colleagues from the Mayo Clinic in Rochester (Minnesota) in the journal Circulation. They studied dogs with diastolic heart failure, a condition in which the heart chamber does not sufficiently fill with blood. The scientists showed that sildenafil makes stiffened cardiac walls more elastic again. The drug activates an enzyme that causes the giant protein titin in the myocardial cells to relax. "We have developed a therapy in an animal model that, for the first time, also raises hopes for the successful treatment of patients" says Prof. Dr. Wolfgang Linke of the RUB Institute of Physiology.

(Excerpt) Read more at eurekalert.org ...


TOPICS: Health/Medicine; Science
KEYWORDS: sildenafil; viagra
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1 posted on 12/23/2011 7:49:56 AM PST by decimon
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To: neverdem; DvdMom; grey_whiskers; Ladysmith; Roos_Girl; Silentgypsy; conservative cat; ...

Ping


2 posted on 12/23/2011 7:50:43 AM PST by decimon
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To: decimon

Wow. Talk about a Win-Win situation.


3 posted on 12/23/2011 7:51:41 AM PST by rbg81
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To: decimon

Frosting on the cake.


4 posted on 12/23/2011 7:52:30 AM PST by TangoLimaSierra (To the left the truth looks Right-Wing.)
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To: decimon

Promotes exercise also. :)


5 posted on 12/23/2011 7:52:30 AM PST by Vinnie
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To: decimon

Sounds promising......I’m assuming it will help women heart patients, also.


6 posted on 12/23/2011 7:53:26 AM PST by basil (It's time to rid the country of "gun free zones" aka "Killing Fields")
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To: decimon

Viagra actually was originally being investigated as a cardiac treatment. Its “downstairs” impact was an unpredicted side effect. True!


7 posted on 12/23/2011 7:53:34 AM PST by pogo101
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To: decimon

Sildenafil helps your heart.....but what about side-effects?/s


8 posted on 12/23/2011 7:55:33 AM PST by Dallas59 (President Robert Gibbs 2009-2011)
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To: decimon

I can always count on Freerepublic to provide the hard facts.


9 posted on 12/23/2011 7:56:29 AM PST by Raycpa
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To: decimon

Warning: If your heart quits beating for more than four hours, notify your doctor! It could be serious.


10 posted on 12/23/2011 7:58:20 AM PST by count-your-change (You don't have to be brilliant, not being stupid is enough.)
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To: decimon

“makes stiffened cardiac walls more elastic again...”

Odd reversal.


11 posted on 12/23/2011 8:00:23 AM PST by lacrew (Mr. Soetoro, we regret to inform you that your race card is over the credit limit.)
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To: decimon
these nitrous release erectile dysfunction drugs were first discovered by accident researching heart drugs

the discoverer of Viagra in it's first form was by accident in England by a researcher who took some inadvertently and noticed he got a wooden buddy.

at his next symposium he gave a talk about it and then stepped away from the podium to display his bulge to his researcher peers

at least according to my urologist friend who really stays abreast of this stuff

Cialis is already a known antidote and or prophylactic to altitude sickness...taken in sustained doses it does help ward off sorroche for high climbers

truly these drugs are a Godsend for men ill before their time but can be the bane of over 40 women who have lost interest in sex in a marriage...or otherwise even

(not my fair maiden..just in case she's reading my posts as she is wont to do)

but I do hear ladies whine about living with that “disgusting pig”..lol

12 posted on 12/23/2011 8:01:27 AM PST by wardaddy (Michelle, Sarah, Perry now Newt over Mitt.....that is how I've seen it and it's where we are)
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To: decimon

This could be disastrous. If it affects females the way it affects males, nobody will ever get anything done. Then again, at least they’ll be healthier. Then again, STD’s would be rampant. Then again....


13 posted on 12/23/2011 8:03:21 AM PST by Silentgypsy (If this creature is not stopped it could make its way to Novosibirsk!)
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To: Silentgypsy
If it affects females the way it affects males, nobody will ever get anything done.

Good point. The reason that hetrosexuals don't jam up every rest stop and bath-house with sex with strangers is the moderating influence of women. Take that away and it's Sodom and Gommorah city.

14 posted on 12/23/2011 8:07:12 AM PST by Fido969
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To: decimon

Build it...they will come.


15 posted on 12/23/2011 8:27:12 AM PST by DainBramage
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To: decimon

My cousin, an attorney, took Viagra for years. Never did a damned thing but make his neck stiff...


16 posted on 12/23/2011 8:31:37 AM PST by donozark (Ron Paul! You magnificent bastard! I read your book! (cook book that is))
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To: rbg81

LOL


17 posted on 12/23/2011 8:43:03 AM PST by Matchett-PI ("One party will generally represent the envied, the other the envious. Guess which ones." ~GagdadBob)
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To: decimon

***sildenafil, the active ingredient in Viagra, can alleviate heart problems****

I believe Viagra was originally designed to to relax and open restricted arteries, similar to nitro.

Then they found erections were a side affect and a whole new field of marketing opened up.


18 posted on 12/23/2011 8:53:56 AM PST by Ruy Dias de Bivar
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To: Silentgypsy
I'm a widow with Pulmonary Fibrosis. The doctors are starting to prescribe Viagra to help the slow down the progression of this terminal disease. I haven’t approached my Dr. yet because........
19 posted on 12/23/2011 9:00:49 AM PST by Coldwater Creek (He who dwells in the shelter of the Most High will rest in the shadow of the Almighty Psalm 91:)
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To: count-your-change

What is that dent in the casket?


20 posted on 12/23/2011 9:16:18 AM PST by taterjay
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