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Fig. 1. Alcohol-induced infralimbic mGluR2 deficit leads to impaired ASST performance. (A) Scheme of chronic alcohol-vapor exposure leading to stable blood alcohol concentrations and significantly increased somatic withdrawal scores. After 3 weeks of abstinence, batches of animals were used either for spine density analysis, attentional set-shifting test (ASST), or lentiviral infralimbic mGluR2 rescue. (B) Scheme of ASST, where rats have to make serial discriminative choices based on olfactory or tactile cues/dimensions. ASST performance of alcohol-dependent [postdependent (PD), n = 14, black squares] rats need significantly more trials to criterion in the IDS and EDS subtasks compared to control rats (n...

Instead of running from terror, the people of Waukesha have stared it in the face with their arms linked — and it's making them stronger.WAUKESHA, Wis. — Guitar For Life Cafe was one of the only unlocked doors on West Main St. in downtown Waukesha on Monday morning, so I stepped inside to buy a cup of coffee. It quickly became clear the shop wasn’t actually open for business.The cafe was dark behind the front counter, with a handful of people scattered among the wooden hightops and stools, nursing paper cups of steaming coffee. It wasn’t immediately apparent when they...

Just weeks after Glenn Youngkin was elected Governor of Virginia, conservatives are already accusing him of stabbing them in the back. His communications staff includes a skirt-wearing LGBT man who lists pronouns in his Twitter biography, and Youngkin’s transition team is led by a former Bush Administration official who is pro-Black Lives Matter. Though Youngkin was elected during a statewide culture war as voters pushed back on the radical left’s LGBT agenda and Critical Race Theory, Joshua Marin-Mora, a member of Glenn Youngkin’s communications staff, appears to be fighting for the opposite side. Marin-Mora lists his preferred pronouns in his...

The suspect charged with five counts of homicide in Sunday’s Waukesha Christmas parade massacre was not being chased by police and “intentionally” drove into the crowd, Waukesha authorities said. During a press conference on Monday, Waukesha Police Chief Dan Thompson confirmed that the suspect, Darrell Brooks Jr., was fleeing a domestic disturbance before he drove his maroon SUV into a crowd, killing five people and injuring 48, including two children who are in critical condition.

Milwaukee County, WI – The Milwaukee County District Attorney’s Office refused to prosecute more than 60 percent of the felony charges police forwarded for prosecution last year. Prosecutors refused to pursue charges in more than 80 percent of misdemeanor filings in December of 2020 alone, Wisconsin Right Now reported. These statistics stemmed from cases that were rejected after being filed, which means the total number of cases Milwaukee County District Attorney John Chisholm’s office refused to file is even higher, according to Wisconsin Right Now. The number of dropped cases, referred to as “no process” cases, was up approximately 10...

The Florida man photographed making off with House Speaker Nancy Pelosi’s lectern during the Jan. 6 riot at the US Capitol pleaded guilty to a lesser charge on Monday. Adam Johnson, 36, admitted to one count of entering or remaining in any restricted building in Washington, DC, federal court, according to records. Sentencing guidelines in Johnson’s plea agreement call for him to receive up to six months in prison, but a federal judge will make the final determination at a hearing scheduled for Feb. 25.

[R]esearchers led by the University of Zurich (UZH) has now discovered another component that contributes to SARS-CoV-2 immunity – previous antibody responses to other, harmless coronaviruses. “People who have had strong immune responses to other human coronaviruses also have some protection against SARS-CoV-2 infection,” says Alexandra Trkola, head of the Institute of Medical Virology at UZH. In their study, the researchers used a specially developed assay to analyze antibody levels against four other human coronaviruses in 825 serum samples taken before SARS-CoV-2 emerged. They also examined 389 samples from donors infected with SARS-CoV-2. Combining these analyses with computer-based models enabled...

A fresh outbreak of the Wuhan coronavirus (Covid-19) is being reported in Connecticut at a nursing home where almost everyone is already “vaccinated.”Nearly 100 people reportedly became infected with the disease and another eight died at the Geer Village Senior Community, a nursing home and rehabilitation center in Canaan.The outbreak supposedly started around the beginning of October when the facility reported three “positive” cases. Since that time, 67 residents and 22 staff members caught the disease, eight residents died, and 48 residents and 21 staff members got sick and later recovered.Of the 89 total infections that have been verified at...

Target, Gap and Walgreens are among 13 companies that have been placed on a Christian conservative legal nonprofit’s “Naughty List” for failing to spotlight Christmas during the holiday season. Last Friday, the Liberty Counsel released its annual “Naughty and Nice Retail List” of businesses that either “recognize and celebrate Christmas” or “silence and censor Christmas.” The compilation criticizes companies that the organization believes are not doing a good enough job of spotlighting the true meaning of Christmas in their holiday-themed branding. According to the list, Target is “naughty” because the retail corporation “has surprisingly few mentions of ‘Christmas,’” though it...

Israeli archaeologists have uncovered evidence they contend backs up the stories of a Jewish victory over Greek rulers – events that are connected to the celebration of Hanukkah. More than two thousand years ago, a hilltop fortress with a commanding view was supposed to protect the Greek-ruled city of Maresha from a legendary Jewish revolt. But Israel Antiquities Authority archaeologists digging in the Lachish Forest, say it didn’t work. They say they have evidence of the Hasmonean Jewish victory – better known as the Maccabees – over the Seleucid Greek rulers – despite Seleucid attempts to fortify and protect the...

RIOTS Erupt In EU Over Vaccine Mandates. While many claimed this would never happen, 38 people were taken by army vehicle and transported to the quarantine facility at howard springs. In the US Fauci says we may need boosters every 6 months In Europe riots have erupted all over as lockdowns become more and more intense. It can happen in America and we are getting closer.

MSNBC’s Al Sharpton on Tuesday sounded off on the uptick in burglaries and looting on the West Coast and New York City as Democrat-led cities have become lax on prosecuting property crime. Sharpton said on “Morning Joe” that “real racism” is progressives acting like people of certain races or communities were incapable of acting better than the “beastly acts” and “vile behavior” they have been normalizing.

Media assertions in the immediate aftermath of the massacre in Waukesha that the killer did not deliberately drive into his victims because he was being ‘pursued by police’ have been proven completely untrue. Imagine my shock. In the early hours after the horror unfolded, the corporate press settled on the narrative that culprit Darrell Edward Brooks Jr was ‘fleeing the scene of a crime’ after being involved in a ‘knife fight’. BREAKING: CNN reports Waukesha driver who plowed into parade was fleeing another crime scene, not an act of terrorism or retaliation. — S.E. Cupp (@secupp) November 22, 2021 This...

Tight Inventory, “Increasing Affordability Challenges,” and Rising Mortgage Rates – The phenomenon of a spurt in buying during the early phases of rising mortgage rates – until they reach a magic number. Actual sales of all types of existing homes fell 8.2% year-over-year to 526,000 homes in October, with sales of single-family houses falling 8.2% year-over-year to 469,000 houses in the month, and sales of condos and co-ops falling 8.1% year-over-year to 57,000 units, according to data from the National Association of Realtors today.

Tesla CEO Elon Musk offered a flippant response to being sued for $162 million by JP Morgan Chase, threatening the nation’s biggest bank with a “one star review on Yelp.” “This is my final warning!” he added.

The U.S. Department of Agriculture announced that it has begun the process of undoing the Trump Administration's policy of allowing more logging in Alaska's rain forest. Secretary Tom Vilsack explained that "we need to keep in step with the President's desire to tamp down the economic activity that contributes to climate change. We can't let the destruction of the energy sector bear the whole weight of the transition to a simpler way of life." Lumber prices have been skyrocketing even with the increased logging allowed under the Trump rules. Choking off this supply will put further upward pressure on industries...

Before the right to keep and bear arms is stated in the Second Amendment, the Founders wrote why they believed it necessary for people to arm themselves as part of a "militia." They said it is a "necessity to the security of a free state." The Founders knew that liberty is not the natural state of humanity and must be defended against government authorities and lawbreakers who try to limit or abolish it. That is why the Preamble to the Constitution begins: "We the people," not you the government. Familiar statements followed the acquittal of Kyle Rittenhouse by a Kenosha,...

WSJ reports Texas Gov. Greg Abbott is scheduled to make a major “economic announcement” on Tuesday at 5 pm local time concerning new plans for a massive semiconductor plant in Taylor, Texas. South Korean tech giant, Samsung Electronics Co., is doubling down in Texas with another facility, about 30 miles from its manufacturing hub in Austin. The new Taylor facility will cost a whopping $17 billion and create 1,800 jobs. Chip production wouldn’t start until the second half of 2024. WSJ said officials in Taylor incentivized Samsung by giving them “property-tax breaks of up to 92.5% for the first ten...

Author J.K. Rowling, the female author who wrote the Harry Potter series, has been outspoken in recent years about protecting the rights of women and keeping definitions of biological gender intact. As a result, she's been tagged as an "anti-transgender" bigot. Just last week, HBO Max confirmed she would not be invited to the 20th anniversary celebration of the series, despite her becoming one of the most successful fictional novelists in the history of the world. Most recently, Rowling faced harassment by transgender activists at her home and detailed the experience

COHEN: Based on your findings, do you believe that Dr. Fauci and Bill Gates should be investigated for criminal wrongdoing? RFK JR.: Yes. COHEN: Plain and simple? RFK JR.: Of course. I mean, I think Fauci's policies -- 80% of the people who died from COVID should not have died. We should've been doing early treatment like the Chinese did. The Chinese put early treatment protocols with chloroquine, which is hydroxy -- the cousin of the hydroxychloroquine. In April, they had protocols with all the drugs we know are effective, anti-coagulants, anti-inflammatory steroids, hydroxychloroquine or chloroquine, and then vitamins, Vitamin...