Researchers determine timing is key for type 2 diabetes drug performance (Take metformin 30-60 mins before meal)
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Medical Xpress / University of Adelaide / Diabetologia ^
| June 7, 2024 | Rhiannon Koch / Cong Xie et al
Researchers could be closer to discovering a better way to use metformin, a common type 2 diabetes medication. Metformin
is typically taken with meals to reduce gastrointestinal side effects, but new research is suggesting patients could see improved results if it's taken before meals. Dr. Cong Xie and a team which studied the gastrointestinal effects of the drug on 16 people living with type 2 diabetes who were already using it to treat the condition. Their findings were published and are now being used in e-learning by the European Association for the Study of Diabetes (one of the largest international...
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Oral insulin drops under the tongue could replace diabetes injections
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New Atlas ^
| June 07, 2024 | Michael Irving
Diabetics sick of daily injections may have renewed hope for a less invasive alternative. Scientists
at the University of British Columbia (UBC) have developed a new delivery method for insulin where users just place a few drops under their tongue. A hallmark of diabetes is the inability to produce enough insulin to regulate blood glucose levels. Those with type 1, and many with type 2, will need insulin a few times a day, and that’s usually delivered through a subcutaneous injection. Not only is that uncomfortable, but it can be hard for patients to stick to, and creates potential biohazard...
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GLP-1 medications for type 2 diabetes and obesity may lower risk of acute pancreatitis
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Medical Xpress / The Endocrine Society / ENDO 2024, the Endocrine Society's annual meeting ^
| June 1, 2024 | Mahmoud Nassar, M.D., Ph.D. et al
Medications for type 2 diabetes and obesity known as GLP-1 receptor agonists may lower the risk of acute pancreatitis recurrence in people with obesity and those with type 2 diabetes, according to a study. Doctors
have been cautious about prescribing these medications in patients with a history of pancreatitis due to the potential risk of worsening the condition, said Mahmoud Nassar, M.D., Ph.D. Acute pancreatitis is a sudden inflammation of the pancreas. The researchers used data from a database called TriNetX, which contains information from about 127 million patients across 15 countries, mainly from the United States. They identified 638,501...
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Chinese scientists cure diabetes using stem cells in world first (type 2)
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Nextshark via Yahoo ^
| 05 27 2024 | Ryan General
Scientists in Shanghai achieved a historic breakthrough after successfully eliminating a long-term patient's type 2 diabetes through a pioneering cell therapy treatment. Key
points: The 59-year-old patient of 25 years received a transplant of pancreatic cells derived from his own stem cells in 2021. He is now insulin independent. This marks the world's first successful use of stem cell-derived islet transplantation to cure diabetes. The achievement, published on Cell Discovery on April 30, comes after over a decade of research at Shanghai Changzheng Hospital. SNIP
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Diabetes drug found to improve cardiovascular outcomes across a range of heart and kidney conditions (SGLT2 inhibitors)
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Medical Xpress / George Institute for Global Health / Circulation ^
| April 8, 2024 | Siddharth M. Patel et al
A new meta-analysis shows sodium glucose co-transporter 2 (SGLT2) inhibitors reduce the risk of major adverse cardiovascular events in patients with either diabetes at high risk of atherosclerotic cardiovascular disease (ASCVD), heart failure, or chronic kidney disease (CKD). SGLT2 inhibitors, also called gliflozins, are a class of drug that lower blood glucose
by increasing its excretion in the urine. While late-stage trials of these medicines have demonstrated reductions in heart failure and adverse kidney outcomes, the effects on major adverse cardiovascular events (MACE), including cardiovascular death, myocardial infarction, and stroke, were less clear. Researchers analyzed data across 11 trials involving...
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How might fiber lower diabetes risk? Your gut could hold the clues
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Medical Xpress / American Heart Association / Circulation Research ^
| March 29, 2024 | Carolyn Bernhardt / Zheng Wang et al
Eating more dietary fiber may help prevent type 2 diabetes by promoting beneficial gut bacteria and substances produced during metabolism, according to research. The
study looked at data from up to 11,000-plus participants in the ongoing Hispanic Community Health Study/Study of Latinos. The researchers found that higher fiber intake was associated with specific "good" gut bacteria and certain favorable metabolites in the blood—some of which were actually produced by gut bacteria. Those gut microbes and metabolites were associated with lower risk of developing type 2 diabetes during an average follow-up of six years. According to federal dietary guidelines, the majority...
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Diabetes drug shows promise against Parkinson's in clinical study (Adlyxin GLP-1 receptor agonist)
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Medical Xpress / AFP / New England Journal of Medicine ^
| April 4, 2024 | Issam Ahmed and Lucie Aubourg / Wassilios G. Meissner et al
A drug used to treat diabetes slowed the progression of motor issues associated with Parkinson's disease, a study said. Researchers
have been interested in exploring a class of drugs called GLP-1 receptor agonists—which mimic a gut hormone and are commonly used to treat diabetes and obesity—for their potential to protect neurons. In the new paper, 156 patients with early-stage Parkinson's were recruited across France and then randomly chosen to receive either lixisenatide, which is sold under the brand names Adlyxin and Lyxumia and made by Sanofi, or a placebo. After one year of follow up, the group on the treatment,...
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How diabetes might lead to Alzheimer's: Study suggests the liver is key
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Medical Xpress / Annual mtg of the American Society for Biochemistry and Molecular Biology ^
| March 25, 2024 | Narendra Kumar et al
New research conducted in mice offers insights into what's going on at the molecular level that could cause people with diabetes to develop Alzheimer's disease. The
study adds to a growing body of research on the links between type 2 diabetes and Alzheimer's disease, which some scientists have called "type 3 diabetes." The findings suggest that it should be possible to reduce the risk of Alzheimer's by keeping diabetes well controlled or avoiding it in the first place, according to researchers. Narendra Kumar led the study. "We think that diabetes and Alzheimer's disease are strongly linked," Kumar said, "and by...
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Researchers report clear shift in arterial diseases in diabetes (High blood sugar and triglycerides encourage peripheral artery disease)
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Medical Xpress / University of Gothenburg / The Lancet Regional Health - Europe ^
| March 28, 2024 | Araz Rawshani et al / Tarik Avdic et al
There has been a redistribution in the risk of arterial disease in type 1 and 2 diabetes. The
risks of heart attack and stroke have decreased significantly, while complications in more peripheral vessels have increased in relative importance, according to studies. The researchers studied two decades of disease trends for virtually all peripheral arterial diseases. The studies include data on 34,263 individuals with type 1 diabetes and 655,250 individuals with type 2 diabetes from the Swedish National Diabetes Register between 2001 and 2020. In relative terms, there has been a gradual shift in risk from arterial diseases in the central...
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Vitamin D Could Help Treat Young People With Type 1 Diabetes, Improve Insulin Production: Discovery Published in JAMA Network Open
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Epoch Times ^
| 03/13/2024 | Amie Dahnke
A high dose of vitamin D could improve the function of insulin-producing beta cells in children and young adults recently diagnosed with Type 1 diabetes.The discovery, published in JAMA Network Open, could mean that a more cost-effective way of managing the disease affecting 1.45 million Americans has been on pharmacy shelves all
along.“Type 1 diabetes affects millions of people and treatment options can often be costly,” Dr. Benjamin Nwosu, chief of endocrinology and director of the diabetes center at Cohen Children’s Medical Center and the principal author of the research paper, said in a press release. “It is exciting to...
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Vitamin D₂ may help preserve honeymoon phase of type I diabetes
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Medical Xpress / ScienceX Network / JAMA Network Open ^
| March 12, 2024 | Bob Yirka / Benjamin Udoka Nwosu et al
A team of medical researchers and doctors reports that administration of vitamin D2 to patients newly diagnosed with diabetes type 1 can prolong the so-called honeymoon phase of the disease. The
group conducted a clinical trial involving giving vitamin D2 supplements to children newly diagnosed with diabetes. Prior research has shown that at the time of diagnosis, most diabetes type 1 patients still have approximately 30% to 50% function in pancreatic beta cells (diabetes occurs when such cells stop making insulin). Sometimes the beta cells continue to function for several months or even years. This time period is known as...
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Study demonstrates one of the reasons why the Mediterranean diet improves kidney health in patients with diabetes (Fewer glycation products from lower heat, fewer carbs, and more olive oil)
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Medical Xpress / University of Córdoba / Diabetes & Metabolism ^
| Feb. 20, 2024 | Francisco M. Gutierrez-Mariscal et al
The Mediterranean diet garners praise once again. In
addition to preventing cardiovascular accidents, this diet can also help slow the deterioration of the kidneys. It is a benefit that, for the first time, has been demonstrated in patients suffering from type 2 diabetes. The key lies in compounds called advanced glycation end products, better known as AGEs. These are molecules with an inflammatory and oxidizing capacity. The study analyzed the levels of these harmful compounds in more than 500 diabetics, comparing, over a period of five years, how two types of healthy diets affect the body: the Mediterranean diet and...
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Type 2 diabetes alters the behavior of disks in the vertebral column, study shows
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Medical Xpress / University of California - San Diego / PNAS Nexus ^
| Feb. 13, 2024 | James L Rosenberg et al
Type 2 diabetes alters the behavior of disks in the vertebral column, making them stiffer, and also causes the disks to change shape earlier than normal. As
a result, the disk's ability to withstand pressure is compromised. This is one of the findings of a new study. Low back pain is a major cause of disability, often associated with intervertebral disk degeneration. People with type 2 diabetes face a higher risk of low back pain and disk-related issues. Yet the precise mechanisms of disk degeneration remain unclear. Investigating the biomechanical properties of the intervertebral disk is crucial for understanding the...
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Weight loss intervention in people with type 2 diabetes influences cancer-associated proteins (Diabetes medicines didn’t)
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Medical Xpress / University of Bristol / eBioMedicine ^
| Jan. 30, 2024 | Caroline J. Bull et al
A weight loss intervention in people with type 2 diabetes was found to alter levels of cancer-related proteins, according to the findings of a new University of Bristol-led study. The
study is the first to show that weight loss in people recently diagnosed with diabetes can change the levels of cancer-related chemicals circulating in the blood. According to Diabetes UK, over five million people in the UK live with diabetes and over 600 million people could be afflicted worldwide by 2045. Weight loss is now a key intervention, thanks to the Diabetes Remission Clinical Trial (DiRECT), which found that a...
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Teaspoon a Day of Common Spice May Reduce Diabetes Risk
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local12 ^
| Wed, January 31st 2024 | Liz Bonis & Megan Burgasser
A new study showed that a teaspoon a day of cinnamon might help reduce a person’s diabetes risk. So,
how much of it does a person need to eat? Teaspoon a day of common spice may reduce diabetes risk (WKRC, CNN Newsource, CBS Newspath) The study was conducted in those with prediabetes, which means a person’s blood sugar levels are higher than normal, but not yet high enough to be considered type two diabetes. It’s also a time when increasing a person’s activity can really make a difference, something that Samantha Goldfeder knows about. "Just the consistency of coming kind...
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13 New Biomarkers Could Help Better Predict Heart Disease Risk in People With Type 2 Diabetes
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News Medical ^
| Jan 27 2024
An international academic consortium has identified 13 biomarkers that significantly improve the ability to accurately predict cardiovascular disease risk in people with type 2 diabetes. The
analysis, conducted by 23 experts from 11 countries, was led by The Johns Hopkins University in the United States, the Chinese University of Hong Kong in Hong Kong, and Lund University in Sweden. Although people with type 2 diabetes are two times more likely to develop cardiovascular disease than those without diabetes, it is a challenge for clinicians to predict who in this population is most at risk. Traditional risk scores, which reflect risk...
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Study: Any remission of diabetes from weight-loss trial associated with lower rates of heart and kidney disease
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Medical Xpress / Diabetologia ^
| Jan. 18, 2024 | Edward W. Gregg et al
While several trials have shown that substantial weight loss using diet and lifestyle can reverse type 2 diabetes, new research is among the first to show the subsequent impact of remission on cardiovascular outcomes. The
new study shows that in patients that took part in the Look AHEAD study, those with any evidence of remission had a 40% lower rate of cardiovascular disease (CVD) and 33% lower rate of chronic kidney disease (CKD). The Look AHEAD study was a multi-center RCT that compared the effect of a 12-year intensive lifestyle intervention (ILI) with that of diabetes support and education (DSE)...
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Plastic Chemicals Causing Infertility, Diabetes Found 'Widespread' In Common Food Items: Report
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Epoch Times ^
| 01/09/2024 | Naveen Arthappully
Many of the foods consumed by Americans are contaminated with harmful plastic chemicals that contribute to health complications like diabetes, cardiovascular disorders, and infertility, said a recent report by the nonprofit group Consumer Reports (CR).Bottles of Coca-Cola at a supermarket of Swiss retailer Denner, as the spread of the COVID-19 disease continues,
in Glattbrugg, Switzerland, on June 26, 2020. (Arnd Wiegmann/Reuters)CR tested 85 food items from 11 categories—beverages, canned beans, condiments, dairy, fast food, grains, infant food, meat and poultry, packaged fruits and vegetables, prepared meals, and seafood, according to the Jan. 4 report. Researchers examined the presence of plasticizers—a...
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The Paradox of How We Treat Diabetes
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TIME ^
| JANUARY 3, 2024 | Gary Taubes
Understanding diabetes today requires holding two conflicting realities in your head simultaneously. First,
diabetes therapy has been revolutionized by a world of new drugs that have become available since the turn of the century—most notably, drugs of the same class as Wegovy and Ozempic that began their existence as diabetes medications and are now hailed as wonder drugs for treating obesity. These drugs do the best job yet of controlling blood sugar and, of course, body weight, which is critical for those Type 2 diabetes, the common form of the disease that constitutes over 90 percent of cases and is...
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Why people with diabetes are more prone to respiratory risk (Very tight blood sugar control fixes it)
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Medical Xpress / Weizmann Institute of Science / Nature ^
| Dec. 14, 2023 | Samuel Philip Nobs et al
Research has revealed how, in diabetics, high levels of blood sugar disrupt the function of key cell subsets in the lungs that regulate the immune response. It
also identifies a potential strategy for reversing this susceptibility and saving lives. Prof. Eran Elinav's team subjected multiple mouse models of types 1 and 2 diabetes to a variety of viral lung infections. The immune reaction, which in nondiabetics eliminates the infection and drives tissue healing, was severely impaired in the diabetic mice, leading to uncontrolled infection, lung damage and eventual death. "High blood sugar levels severely disrupt certain subsets of dendritic cells...
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