Posted on 06/04/2024 7:18:16 PM PDT by ConservativeMind
Medications for type 2 diabetes and obesity known as GLP-1 receptor agonists may lower the risk of acute pancreatitis recurrence in people with obesity and those with type 2 diabetes, according to a study.
Doctors have been cautious about prescribing these medications in patients with a history of pancreatitis due to the potential risk of worsening the condition, said Mahmoud Nassar, M.D., Ph.D. Acute pancreatitis is a sudden inflammation of the pancreas.
The researchers used data from a database called TriNetX, which contains information from about 127 million patients across 15 countries, mainly from the United States. They identified 638,501 individuals with a history of acute pancreatitis.
The researchers used a large database called TriNetX, which contains information from about 127 million patients across 15 countries, mainly from the United States. They identified 638,501 individuals with a history of acute pancreatitis.
They focused on adults with diabetes and obesity who had been diagnosed with acute pancreatitis. The researchers wanted to see if certain medications for diabetes and obesity (specifically, GLP-1 receptor agonists, SGLT2 inhibitors and DPP4 inhibitors) affected their risk of getting pancreatitis again.
To figure out the risk of pancreatitis, they tracked how many patients developed pancreatitis again within 5 years of starting their medication. They compared groups of patients taking different medications, matching them by patient characteristics.
When the GLP-1 group was compared with patients taking SGLT2 inhibitors, the GLP-1 group showed a lower risk of acute pancreatitis recurrence (15.2%) compared with 24% in the SGLT2i group. When GLP-1 patients were compared with those taking DPP4i drugs, the GLP-1 group's recurrence risk was 14.4%, compared with 23.3% in the DPP4i group. When GLP-1 patients were compared with those not taking any of these medications, the GLP-1 group's recurrence risk was 14.5%, compared with 51.6% in the comparison group.
(Excerpt) Read more at medicalxpress.com ...
The drugs do not appear to hurt the very patients they feared could be hurt, by them.
bookmark for later.
GLP-1 drugs are the Ozempic, Trulicity type shot for diabetes control.
You need to be SUPER well informed before taking these drugs because your prescribing doctor surly isn’t.
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