5 things to know about pancreatic cancer
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Mayo Clinic Comprehensive Cancer Center Blog News, information and stories from Mayo Clinic’s cance ^
| 11/22/21 | Nicole Brudos Ferrara
"It's not a particularly common cancer," says Mark Truty, M.D., a surgical oncologist at Mayo Clinic. "The lifetime risk of pancreatic cancer for any given patient without any predisposing risk is only 1 to 3%." According
to the National Cancer Institute, pancreatic cancer accounts for 3.2% of all new cancer cases, but it causes nearly 8% of all cancer deaths. And the five-year survival rate for pancreatic cancer is just 10.8%. Here are five things everyone should know about this deadly cancer: Pancreatic cancer is aggressive and causes nonspecific symptoms.
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‘I stand in faith:’ Congresswoman Sheila Jackson Lee announces pancreatic cancer diagnosis
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Click 2 Houston ^
| 06/02/24 | Christian Terry
Snip “My doctors have confirmed my diagnosis of pancreatic cancer. I
am currently undergoing treatment to battle this disease that impacts tens of thousands of Americans every year.
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Anyone seeing an uptick in pancreatic cancer?
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Chickensoup | chickensoup
Anyone seeing an uptick in pancreatic cancer? Formerly
a rare cancer it seems to be burgeoning. I have 2 neighbors within a half mile, a good friend and two inlaws who have/ had pc in past 2 years 4 have passed. Odd to know of so many. That doesn't count my work acquaintances. I am not interested in talking about the vaxxes. Just in the incidence of pc. We are far enough flung that it might be interesting. Your experience? Anyone else?
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Mother, 62, is diagnosed with world's deadliest cancer (Pancreatic) years in advance thanks to artificial-intelligence-powered blood test: 'AI saved my life, I won the lottery'
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Daily Mail ^
| 4.25.2024 | Caitlin Tilley
Like millions of people in the US, artificial intelligence was just something Dianne Balon read about on the news. Little
did she know the tech would come to save her life. Despite being a picture of health, an AI-powered blood test in 2022 revealed that one of the world's deadliest cancers was silently forming in Ms Balon's pancreas. It caught the tumor in its earliest form, before it had the chance to grow and spread, which is when the vast majority of pancreatic cancers are caught - at which point it's too late. The results of the test provided a...
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Blow for Putin as key warlord ally ‘has incurable pancreatic disease’
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Metro UK ^
| 4/22/2024 | Katie Boyden
Vladimir Putin is no stranger to rumours about his own health – but now the health of one of his closest allies has been called into question. Exiled
newspaper Novaya Gazeta Europe claims that Chechen warlord Ramzan Kadyrov, 47, is suffering from pancreatic disease and has ‘no hope of recovery’. The news outlet says Kadyrov – a leading ally of the dictator’s war against Ukraine – has been living with ‘pancreatic necrosis’ for more than five years, which explains his frequent absences from the public stage. An extraordinary new picture shows the Chechen warlord looking unusually bloated. Novaya Gazeta Europe...
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Pancreatic enzymatic replacement therapy improves maladaptive behavior in preschool children with autism, finds study (Common enzymes = “Significant decreases“)
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Medical Xpress / University of Texas Health Science Center at Houston / JAMA Network Open ^
| Dec. 18, 2023 | Halle Jones / Deborah A. Pearson et al
The use of high-protease pancreatic replacement therapy demonstrated improvement in maladaptive behaviors, such as irritability, in preschool children with autism spectrum disorder (ASD), according to research. "Children
who have ASD often have a number of co-occurring maladaptive behaviors, such as irritability. We wanted to know whether these maladaptive behaviors can be addressed by an intervention with a low risk of side effects," said Deborah A. Pearson, Ph.D. Pearson said many children with ASD are selective about the foods they eat, often preferring carbohydrates like bread and pasta over protein. Some amino acids necessary for building neurotransmitters, such as serotonin and...
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Study directly links high insulin levels to pancreatic cancer
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Medical Xpress / University of British Columbia / Cell Metabolism ^
| Oct. 31, 2023 | Dr. Anni Zhang et al
A study reveals a direct link between high insulin levels, common among patients with obesity and type 2 diabetes, and pancreatic cancer. The
study provides the first detailed explanation of why people with obesity and type 2 diabetes are at an increased risk of pancreatic cancer. The research demonstrates that excessive insulin levels overstimulate pancreatic acinar cells, which produce digestive juices. This overstimulation leads to inflammation that converts these cells into precancerous cells. "Alongside the rapid increase in both obesity and type 2 diabetes, we're seeing an alarming rise in pancreatic cancer rates," said Dr. James Johnson. "These findings help...
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Alex Trebek's home of almost 30 years in LA is in the process of being demolished by new owners... two years after he died at the estate at age 80 from pancreatic cancer
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Daily Mail ^
The LA home of the late Alex Trebek is set to be demolished this week, TMZ revealed. The
iconic Jeopardy host lived in the Studio City mansion for almost three decades - renovating the home himself over the years. Alex died in the home on November 8, 2020 at age 80 from pancreatic cancer, with wife Jean Trebek selling the home in January 2022 for $6.45M. The outlet reported that bulldozers and excavators were seen over the weekend arriving to the house - along with a tarp that went up, per his former neighbors. The crew was seen taking the...
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Lorazepam treatment may be linked to worse outcomes for pancreatic cancer patients (Associative progression risk -68% (Xanax) vs. +383% (Ativan))
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Medical Xpress / American Association for Cancer Research / Clinical Cancer Research ^
| Aug. 16, 2023 | Abigail Cornwell et al
Patients with pancreatic cancer who took the benzodiazepine lorazepam (Ativan), commonly prescribed to treat anxiety during cancer treatment, had a shorter progression-free survival than patients who did not, according to results published. In
contrast, patients who took the benzodiazepine alprazolam (Xanax) had a significantly longer progression-free survival than patients who did not. The researchers examined the relationship between benzodiazepine use and survival in patients with pancreatic cancer. When adjusted, any benzodiazepine use was associated with a 30% lower risk of pancreatic cancer-related death. However, when Feigin and colleagues studied the relationship between individual benzodiazepines and pancreatic cancer outcomes, they found...
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Treatment potential of herbal extract compound isoliquiritigenin for pancreatic cancer
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Medical Xpress / Hong Kong Baptist University / Phytomedicine ^
| Aug. 7, 2023 | Zhu Zhang et al
Scientists found isoliquiritigenin (ISL), a flavonoid from licorice, can inhibit pancreatic cancer progression. It
may also enhance the efficacy of conventional chemotherapeutic drugs in treating pancreatic cancer. The team demonstrated that ISL suppressed growth and induced apoptosis of pancreatic cancer cells. In two human pancreatic cancer cell lines applied with 12.5 μM and 25 μM concentrations of ISL respectively, their cell survival rates were about 50% and 80% lower than control cells with no ISL applied. The percentage of late stage apoptosis in the two cell lines was 11% and 13% respectively, compared to less than 5% in the control...
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Study finds high blood glucose levels sensitizes pancreatic cancer cells to chemotherapy
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Medical Xpress / University Hospitals Cleveland Medical Center / Nature Communications ^
| July 26, 2023 | Ali Vaziri-Gohar et al
Pancreatic cancer is one of the most difficult cancers to treat, being highly resistant to chemotherapy. However,
there are no effective alternative therapies to chemotherapy, so chemo remains the best available treatment. Researchers report that a hyperglycemic state—that is, one where the blood glucose level is raised—made pancreatic cancer more sensitive to chemotherapy in a mouse model. (Pancreatic cancer is more formally known as Pancreatic Ductal Adenocarcinoma and shortened as PDAC). Results were replicated in cell culture and a cohort of patients with metastatic PDAC. These findings present a potentially new method of making chemotherapy more effective against pancreatic cancer,...
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Beware the Splice of Life: This Killer Protein Causes Pancreatic Cancer
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Scitech Daily ^
| JUNE 4, 2023 | By COLD SPRING HARBOR LABORATORY
Mouse pancreas cells with high levels of the protein SRSF1; CSHL Professor Adrian Krainer found that mice with high levels of SRFS1 tend to exhibit intraepithelial neoplasia—a known precursor to the most common form of pancreatic cancer. Credit:
Krainer lab/Cold Spring Harbor Laboratory Researchers at the Cold Spring Harbor Laboratory found that the protein SRSF1, which regulates RNA splicing, plays a critical role in the development of pancreatic ductal adenocarcinoma (PDAC), a deadly form of pancreatic cancer. Elevated levels of SRSF1 lead to inflammation and stimulate tumor growth, while restoring normal levels halts the disease’s progress. This discovery could pave...
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New research reveals how vitamin K helps protect against diabetes (Pancreatic beta cells need it)
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Medical Xpress / University of Montreal / Cell Reports ^
| May 18, 2023 | Julie Lacombe et al
Canadian researchers have identified a new role for vitamin K and gamma-carboxylation in beta cells and their potentially protective role in diabetes. The
study explains, at least in part, how vitamin K helps prevent diabetes, and could lead to new therapeutic applications for type 2 diabetes. Vitamin K is a micronutrient known for its role in blood clotting, in particular in gamma-carboxylation, an enzymatic reaction essential to the process. It has been suspected for several years that this vitamin, and thus gamma-carboxylation, may have other functions as well. Several studies suggest a link between a reduced intake of vitamin K...
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Jerry Springer dies aged 79 after months-long battle with pancreatic cancer in his Chicago home surrounded by his family - as they say the tabloid TV legend's 'heart and humor will live on'
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Daily Mail UK ^
| April 27, 2023 | Emma James
Jerry Springer has died aged 79 just months after being diagnosed with pancreatic cancer, his family revealed on Thursday. The legendary TV host passed away 'peacefully' at his home in Chicago after his health took a turn for the worse, a spokesman for his relatives said. Tributes
have flooded in for the 'irreplaceable' talent, with his family adding that his 'heart and humor' will live on. Megyn Kelly and Piers Morgan led the tributes for the star, calling him an 'intelligent, warm' and 'funny' man. Springer hosted the smash hit 'The Jerry Springer Show' for 27 years, becoming America's guilty...
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Jerry Springer dies aged 79 after months-long battle with pancreatic cancer in his Chicago home surrounded by his family - as they say the tabloid TV legend's 'heart and humor will live on'
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Daily Mail UK ^
| April 27, 2023 | Emma James
Jerry Springer has died aged 79 just months after being diagnosed with pancreatic cancer, his family revealed on Thursday. The legendary TV host passed away 'peacefully' at his home in Chicago after his health took a turn for the worse, a spokesman for his relatives said. Tributes
have flooded in for the 'irreplaceable' talent, with his family adding that his 'heart and humor' will live on. Megyn Kelly and Piers Morgan led the tributes for the star, calling him an 'intelligent, warm' and 'funny' man. Springer hosted the smash hit 'The Jerry Springer Show' for 27 years, becoming America's guilty...
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Study identifies how microbiome may affect pancreatic cancer outcomes (Two common gut bacteria make the difference)
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Medical Xpress / University of Cincinnati / Cancer ^
| April 3, 2024 | Tim Tedeschi / Jordan Kharofa et al
Even as pancreatic cancer treatments improve, only about 9% of patients survive past five years. Researchers
have searched unsuccessfully to find genetic differences that explain why some patients survive long term and some do not and have now shifted their focus to the gut microbiome. The microbiome is a term used for the collection of microbes, including microorganisms like bacteria, that live on or in the human body. Jordan Kharofa, MD, said there was little known about the microbiome of long-term pancreatic cancer survivors. "There is emerging science suggesting that pancreas cancer survivors have a robust immune response in their...
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‘Pentagon Papers’ whistleblower Daniel Ellsberg diagnosed with pancreatic cancer
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Berkeleyside ^
| March 6, 2023 | Nico Savidge
Daniel Ellsberg, the former government analyst who leaked a trove of classified documents that became known as the “Pentagon Papers” and has lived near Berkeley for more than four decades, announced that he has been diagnosed with terminal cancer. In
a Facebook post Thursday, Ellsberg wrote that doctors told him that he has inoperable pancreatic cancer, and estimated he has three to six months to live. Ellsberg, 91, has decided to forgo chemotherapy.
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How gut bacteria can impact treatments for cancer (Eat more tryptophan with your chemo, even with pancreatic cancer)
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Medical Xpress / Nature ^
| March 1, 2023 | Bob Yirka / Joseph Tintelnot et al / Le Li et al
A large team has discovered some of the ways gut bacteria can positively impact treatments for cancer. The
group studied the impact of gut microbiota on chemotherapy given to patients with pancreatic ductal adenocarcinoma. Prior research has shown that chemotherapy for pancreatic cancer that has metastasized sometimes works well but is sometimes ineffective, and this difference may be tied to dietary resistance, though its source is not known. In this new study, the team looked at the possibility that certain microorganisms in the gut microbiome play a role in the process. To better understand how the gut microbiome might play...
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New insights into how blood pressure drug may benefit patients with locally advanced pancreatic cancer (Losartan)
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Medical Xpress / Massachusetts General Hospital / Clinical Cancer Research ^
| Feb. 15, 2023 | Yves Boucher et al
Pancreatic cancer is highly lethal, and surgical removal of tumor tissue is currently the only potential cure for most patients. Once
the cancer has spread beyond the pancreas, treatment options are limited. A recent phase II clinical trial identified a promising combination treatment regimen for patients with locally advanced pancreatic cancer, meaning that their cancer had spread, but only to nearby tissue. The trial's investigators have now uncovered the potential mechanisms behind the treatment's beneficial effects. The combination therapy—losartan+FFX+CRT—includes the blood pressure drug losartan plus a chemotherapy cocktail called FOLFIRINOX (folinic acid, fluorouracil, irinotecan, and oxaliplatin), followed by chemoradiation. The...
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Largest study of its kind reveals adjuvant chemotherapy improves overall survival for pancreatic cancer patients
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Medical Xpress / CU Anschutz Medical Campus / JAMA Oncology ^
| Dec. 8, 2022 | Toshitaka Sugawara et al
New research showcases chemotherapy treatment before and after surgery for pancreatic cancer as the most effective combination for patients. "It's
critical to have large scale data that doctors can use to make decisions about chemotherapy plans for patients who qualify for pancreatic cancer surgery," said author Marco Del Chiaro, MD. The study showed overall survival was significantly longer in patients who received adjuvant chemotherapy after neo-adjuvant chemotherapy followed by surgery, compared to the group of patients that did not receive it. This was the case for all patients independent of their lymph node status and resection margins. "The success of...
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