Posted on 08/10/2023 6:30:08 AM PDT by ConservativeMind
Scientists found isoliquiritigenin (ISL), a flavonoid from licorice, can inhibit pancreatic cancer progression. It may also enhance the efficacy of conventional chemotherapeutic drugs in treating pancreatic cancer.
The team demonstrated that ISL suppressed growth and induced apoptosis of pancreatic cancer cells. In two human pancreatic cancer cell lines applied with 12.5 μM and 25 μM concentrations of ISL respectively, their cell survival rates were about 50% and 80% lower than control cells with no ISL applied. The percentage of late stage apoptosis in the two cell lines was 11% and 13% respectively, compared to less than 5% in the control cells.
The team employed a mice tumor model. Mice were divided into three groups with GEM (GEM group), ISL (ISL group) and no treatment agent (control group) applied. The ISL group was further divided into two sub-groups treated with 30mg/kg and 60mg/kg of ISL.
On the 21st day of the experiment, tumor volumes of the control group and the GEM group were 1,000 mm3 and 400 mm3 respectively. The tumor volumes of the two ISL sub-groups treated with 30mg/kg and 60mg/kg of ISL were about 500 mm3 and 300 mm3 respectively. The results showed that ISL demonstrated treatment effects comparable to that of GEM. Meanwhile, compared with GEM, ISL showed fewer side effects in mice including neutropenia (drop in white blood cell count), anemia and body weight loss.
To explore ISL's potential in counteracting the chemoresistance of GEM and 5-FU, the research team set up experiments with pancreatic cancer cells treated with GEM or 5-FU alone, and GEM or 5-FU together with ISL. The growth inhibition rate of pancreatic cancer cells applied with GEM and ISL together is 18% higher than using GEM only, while the growth inhibition rate using 5-FU and ISL together is 30% higher than 5-FU only.
(Excerpt) Read more at medicalxpress.com ...
It appeared to work the same, or better than, chemo, when including the side effect profile.
ping
Wow. Thank you. Oddly enough, I use DGL liquorice. I’ll use more!
Can you please provide the brand and where you purchased this? Thank you.
DGL? Swanson.com
Flavonoids and flavanoids... good things.
Pancreatic adenocarcinoma remains uniquely resistant to chemo treatment. The Israelis are way out ahead of us in finding new avenues.
That is great news. Anything for pancreatic cancer is great news.
**
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.