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Treatment potential of herbal extract compound isoliquiritigenin for pancreatic cancer
Medical Xpress / Hong Kong Baptist University / Phytomedicine ^ | Aug. 7, 2023 | Zhu Zhang et al

Posted on 08/10/2023 6:30:08 AM PDT by ConservativeMind

Scientists found isoliquiritigenin (ISL), a flavonoid from licorice, can inhibit pancreatic cancer progression. It may also enhance the efficacy of conventional chemotherapeutic drugs in treating pancreatic cancer.

The team demonstrated that ISL suppressed growth and induced apoptosis of pancreatic cancer cells. In two human pancreatic cancer cell lines applied with 12.5 μM and 25 μM concentrations of ISL respectively, their cell survival rates were about 50% and 80% lower than control cells with no ISL applied. The percentage of late stage apoptosis in the two cell lines was 11% and 13% respectively, compared to less than 5% in the control cells.

The team employed a mice tumor model. Mice were divided into three groups with GEM (GEM group), ISL (ISL group) and no treatment agent (control group) applied. The ISL group was further divided into two sub-groups treated with 30mg/kg and 60mg/kg of ISL.

On the 21st day of the experiment, tumor volumes of the control group and the GEM group were 1,000 mm3 and 400 mm3 respectively. The tumor volumes of the two ISL sub-groups treated with 30mg/kg and 60mg/kg of ISL were about 500 mm3 and 300 mm3 respectively. The results showed that ISL demonstrated treatment effects comparable to that of GEM. Meanwhile, compared with GEM, ISL showed fewer side effects in mice including neutropenia (drop in white blood cell count), anemia and body weight loss.

To explore ISL's potential in counteracting the chemoresistance of GEM and 5-FU, the research team set up experiments with pancreatic cancer cells treated with GEM or 5-FU alone, and GEM or 5-FU together with ISL. The growth inhibition rate of pancreatic cancer cells applied with GEM and ISL together is 18% higher than using GEM only, while the growth inhibition rate using 5-FU and ISL together is 30% higher than 5-FU only.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: cancer
This substance is available today, at $80/gram on Amazon, for your doctors to consider.

It appeared to work the same, or better than, chemo, when including the side effect profile.

1 posted on 08/10/2023 6:30:08 AM PDT by ConservativeMind
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To: Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ProtectOurFreedom; matthew fuller; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20 - 25% fewer pings) or “Everything” list.

2 posted on 08/10/2023 6:30:39 AM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: AuntB

ping


3 posted on 08/10/2023 6:32:22 AM PDT by null and void (It's 10 o'clock, does the president know where he is?)
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To: null and void

Wow. Thank you. Oddly enough, I use DGL liquorice. I’ll use more!


4 posted on 08/10/2023 7:16:46 AM PDT by AuntB (Trump is our Ben Franklin - Brilliant, Boisterous, Brave and ALL AMERICAN!)
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To: AuntB

Can you please provide the brand and where you purchased this? Thank you.


5 posted on 08/10/2023 7:21:53 AM PDT by peggybac (My will is what I wanted. God's will is what I got.)
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To: peggybac

DGL? Swanson.com


6 posted on 08/10/2023 8:00:51 AM PDT by AuntB (Trump is our Ben Franklin - Brilliant, Boisterous, Brave and ALL AMERICAN!)
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To: ConservativeMind
Curcumin, also a flavonoid with a somewhat similar structure, has also shown promise as a therapeutic adjunct in PC.

Flavonoids and flavanoids... good things.

7 posted on 08/10/2023 8:08:01 AM PDT by Seaplaner (Never give in. Never give in. Never, never, never...in nothing, great or small...Winston ChurchIill)
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To: ConservativeMind

Pancreatic adenocarcinoma remains uniquely resistant to chemo treatment. The Israelis are way out ahead of us in finding new avenues.


8 posted on 08/10/2023 8:16:39 AM PDT by lurk (u)
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To: ConservativeMind

That is great news. Anything for pancreatic cancer is great news.


9 posted on 08/10/2023 8:37:32 AM PDT by MarMema (Eat your bananas, enjoy the decline)
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To: ConservativeMind

**


10 posted on 08/10/2023 1:41:17 PM PDT by Taffini ( Mr. Pippen and Mr. Waffles do not approve and neither do I)
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