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Scientists Plan to Rebuild Neanderthal Genome
New York Times ^ | July 20, 2006 | Nicholas Wade

Posted on 07/20/2006 4:06:56 PM PDT by CobaltBlue

Researchers at the Max Planck Institute for Evolutionary Biology in Leipzig, Germany, plan to reconstruct the genome of Neanderthals, the archaic human species that occupied Europe from 300,000 years ago until 30,000 years ago until being displaced by modern humans.

The genome will initially be reconstructed using DNA extracted from Neanderthal bones that are 45,000 years old, which were found in Croatia, though bones from other sites may be analyzed later.

The project is a collaboration between Dr. Svante Paabo of the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, and 454 Life Sciences, a Connecticut company that has developed a new method of sequencing, or decoding, DNA.

The sequencing of Neanderthal DNA, long a forlorn hope, suddenly seems possible because of a combination of analytic work on ancient DNA by Dr. Paabo and a new kind of DNA sequencing machine developed by 454 Life Sciences.

Because the genome must be kept in constant repair and starts to break up immediately after the death of the cell, the DNA in Neanderthal bones exists in tiny fragments 100 or so units in length. As it happens, this is just the length that works best with the 454 machine, which is also able to decode vast amounts of DNA at low cost.

(Excerpt) Read more at nytimes.com ...


TOPICS: Culture/Society; Extended News; News/Current Events
KEYWORDS: artbell; callingartbell; dna; genome; ggg; godsgravesglyphs; helixmakemineadouble; kooktokookam; neandertal; neandertals; neanderthal; neanderthals; notcool
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To: phoenix0468
What do they plan to do with the DNA?

Sequence it.

61 posted on 07/20/2006 9:12:56 PM PDT by Doctor Stochastic (Vegetabilisch = chaotisch ist der Charakter der Modernen. - Friedrich Schlegel)
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To: TheHound

The article you link states regarding Rh factors:
"antibodies to Rh+ blood in the woman which typically attack the blood of her subsequent Rh+ children, causing them to miscarry, be stillborn, or die shortly after birth (infant haemolytic disease [6]). This phenomenon is unknown elsewhere in nature..."

This type of blood antibody reaction is known to occur in other animals. And only a very few other animals have been studied for this. So it is possible that this occurs in many animals other than humans.


62 posted on 07/20/2006 9:24:17 PM PDT by RouxStir (No Islam, Know Peace)
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To: AdmSmith; AnalogReigns; caryatid; CobaltBlue; concentric circles; Domestic Church; Emmalein; ...
Genetic
Genealogy
Send FReepmail if you want on/off GGP list
Marty = Paternal Haplogroup O(2?)(M175)
Maternal Haplogroup H
GG LINKS:
African Ancestry
DNAPrint Genomics
FamilyTree DNA
mitosearch
Nat'l Geographic Genographic Project
Oxford Ancestors
RelativeGenetics
Sorenson Molecular Genealogy Foundation
Trace Genetics
ybase
ysearch
The List of Ping Lists

63 posted on 07/20/2006 9:49:36 PM PDT by martin_fierro (< |:)~)
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To: patton

...and I'll pull your finger. Well said.


64 posted on 07/20/2006 10:06:37 PM PDT by SunkenCiv (updated my FR profile on Wednesday, June 21, 2006. https://secure.freerepublic.com/donate/)
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To: CobaltBlue; blam
Thanks for the topic. We may have one already, but I'm tired and lazy, so I'm going to ping this one.
The Neandertal Enigma
by James Shreeve
Frayer's own reading of the record reveals a number of overlooked traits that clearly and specifically link the Neandertals to the Cro-Magnons. One such trait is the shape of the opening of the nerve canal in the lower jaw, a spot where dentists often give a pain-blocking injection. In many Neandertal, the upper portion of the opening is covered by a broad bony ridge, a curious feature also carried by a significant number of Cro-Magnons. But none of the alleged 'ancestors of us all' fossils from Africa have it, and it is extremely rare in modern people outside Europe." [pp 126-127]

65 posted on 07/20/2006 10:07:23 PM PDT by SunkenCiv (updated my FR profile on Wednesday, June 21, 2006. https://secure.freerepublic.com/donate/)
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To: ValerieUSA

London - Red hair may be the genetic legacy of Neanderthals...
Planet Save.com | 1/14/05 | Planet Save.com
Posted on 01/16/2005 3:47:07 PM EST by IGBT
http://www.freerepublic.com/focus/f-news/1322006/posts

Redheads are better at coping with pain
CTV.ca
Posted on 08/11/2005 3:10:20 PM EDT by Grig
http://www.freerepublic.com/focus/f-news/1461462/posts

(Redheads)That Flaming Hair Could Mean Flaming Pain - Study
Yahoo! News (Reuters) | 10/14/02 | n/a
Posted on 10/14/2002 6:16:45 PM EDT by Pyro7480
http://www.freerepublic.com/focus/news/769078/posts

American Neanderthal?
ABC News | 02-18-2000
Posted on 01/21/2002 8:30:59 AM EST by blam
http://www.freerepublic.com/focus/news/612553/posts


66 posted on 07/20/2006 10:20:16 PM PDT by SunkenCiv (updated my FR profile on Wednesday, June 21, 2006. https://secure.freerepublic.com/donate/)
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To: blam; FairOpinion; StayAt HomeMother; Ernest_at_the_Beach; 24Karet; 3AngelaD; ...
To all -- please ping me to other topics which are appropriate for the GGG list. Thanks.
Please FREEPMAIL me if you want on or off the
"Gods, Graves, Glyphs" PING list or GGG weekly digest
-- Archaeology/Anthropology/Ancient Cultures/Artifacts/Antiquities, etc.
Gods, Graves, Glyphs (alpha order)

67 posted on 07/20/2006 10:20:59 PM PDT by SunkenCiv (updated my FR profile on Wednesday, June 21, 2006. https://secure.freerepublic.com/donate/)
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To: CobaltBlue

I bet some of those scientists are dreaming about creating a functional set of Neanderthal chromosomes to be injected into a denucleated human egg, and then implanting the resulting embryo into a surrogate mother for gestation.

Yeah... No harm in them dreaming. Heck, it would probably make an interesting kid's story.


68 posted on 07/20/2006 10:25:29 PM PDT by coconutt2000 (NO MORE PEACE FOR OIL!!! DOWN WITH TYRANTS, TERRORISTS, AND TIMIDCRATS!!!! (3-T's For World Peace))
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To: CobaltBlue

69 posted on 07/21/2006 12:10:57 AM PDT by ASA Vet (3.03)
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To: CobaltBlue
Damn! Liberals will do ANYTHING to get more votes for the dems!

Mark

70 posted on 07/21/2006 12:50:23 AM PDT by MarkL (When Kaylee says "No power in the `verse can stop me," it's cute. When River says it, it's scary!)
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To: after dark

Most modern evolutionists think there existed some unknown apelike ancestor of both modern man and Neandertal, but not that Neandertal was an ancestor of modern man.


71 posted on 07/21/2006 1:05:26 AM PDT by HiTech RedNeck
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To: coconutt2000

My Little Brother Lives At The Zoo


72 posted on 07/21/2006 1:06:37 AM PDT by HiTech RedNeck
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To: Kermit the Frog Does theWatusi

Why waste time piecing together DNA from 45,000-yr-old bones when there are
living specimens fresh at hand living and prowling in Washington and New York?

73 posted on 07/21/2006 1:06:48 AM PDT by HowlinglyMind-BendingAbsurdity
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To: pabianice

You think the public schools system is bad now!


74 posted on 07/21/2006 4:59:25 AM PDT by Recon Dad (Marine Spec Ops Dad)
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To: HiTech RedNeck
I never thought of Neanderthal as an ancestor.

It is possible that Neanderthal could have mated with the unknown apelike ancestor and vice versa.
75 posted on 07/21/2006 5:00:14 AM PDT by after dark (I love hateful people. They help me unload karmic debt.)
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To: after dark

This would mean the races/species were close enough to be united into one. The number of chromosomes is different so any attempt would result in severely disabled offspring, if any.


76 posted on 07/21/2006 5:10:43 AM PDT by HiTech RedNeck
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To: after dark
This unknown apelike ancestor could have facilitated the transference of genetic material from humans to Neanderthals and the reverse.

I think most of the studies which have failed to show the presence of Neanderthal genes only look at mitochondrial DNA.

I also think they cast their net to far. They should only study populations living in the areas where Neanderthal coexisted with humanity, and places where Neanderthals were able to hold out the longest.
77 posted on 07/21/2006 5:11:07 AM PDT by after dark (I love hateful people. They help me unload karmic debt.)
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To: CobaltBlue
We should soon have the ability to reconstruct a number of pleistocene animals, most particularly the mammoths.

I would recommend against trying to reconstruct neanderthals however. There were probably real reasons why the neanderthal died out, and very likely requirements of modern life which the neanderthal was simply incapable of, and spoken speech could easily have been one such. A neanderthal trying to live in our world would not be happy.

This is one of Jay Matternes' reconstructions of a neanderthal:

And this is what some refer to as "non representational art" from the Indus Valley civilization, the so-called "priest/king" figurine:

Matternes had no way to know how much the brow ridges would show on a live subject and the jaw and forehead are identical. Somebody might have neglected to tell the artists of Mohenjo Daro or Harappa that neanderthals were supposed to have died out 40,000 years ago.

Then again, if you can read German, there is Gunnar Heinsohn's Wie Alt ist das Menschengeschlect in which Heinsohn, one of Europe's best scholars, claims that there is no legitimate reason based on stratigraphy or proper analyses of stratigraphical studies to think that neanderthals died out any more than about 3000 years ago.

Heinsohn notes (in English) that:

Mueller-Karpe, the first name in continental paleoanthropology, wrote thirty years ago on the two strata of homo erectus at Swanscombe/England: "A difference between the tools in the upper and in the lower stratum is not recognizable. (From a geological point of view it is uncertain if between the two strata there passed decades, centuries or millennia.)" (Handbuch der Vorgeschichte, Vol I, Munich 1966, p. 293).

The outstanding scholar never returned to this hint that in reality there may have passed ten years where the textbooks enlist one thousand years. Yet, I tried to follow this thread. I went to the stratigraphies of the Old Stone Age which usually look as follows

modern man (homo sapiens sapiens)

Neanderthal man (homo sapiens neanderthalensis)

Homo erectus (invents fire and is considered the first intelligent man).

In my book "Wie alt ist das Menschengeschlecht?" [How Ancient is Man?], 1996, 2nd edition, I focused for Neanderthal man on his best preserved stratigraphy: Combe Grenal in France. Within 4 m of debris it exhibited 55 strata dated conventionally between -90,000 and -30,000. Roughly one millennium was thus assigned to some 7 cm of debris per stratum. Close scrutiny had revealed that most strata were only used in the summer. Thus, ca. one thousand summers were assigned to each stratum. If, however, the site lay idle in winter and spring one would have expected substratification. Ideally, one would look for one thousand substrata for the one thousand summers. Yet, not even two substrata were discovered in any of the strata. They themselves were the substrata in the 4 m stratigraphy. They, thus, were not good for 60,000 but only for 55 years.

I tested this assumption with the tool count. According to the Binfords' research--done on North American Indians--each tibal adult has at least five tool kits with some eight tools in each of them. At every time 800 tools existed in a band of 20 adults. Assuming that each tool lasted an entire generation (15 female years), Combe Grenals 4,000 generations in 60,000 years should have produced some 3.2 million tools. By going closer to the actual life time of flint tools tens of millions of tools would have to be expected for Combe Grenal. Ony 19,000 (nineteen thousand) remains of tools, however, were found by the excavators.

There seems to be no way out but to cut down the age of Neanderthal man at Combe Grenal from some 60,000 to some 60 years.

I applied the stratigraphical approach to the best caves in Europe for the entire time from Erectus to the Iron Age and reached at the following tentative chronology for intelligent man:

-600 onwards Iron Age
-900 onwards Bronze Age
-1400 beginning of modern man (homo sapiens sapiens)
-1500 beginning of Neanderthal man
between -2000 and -1600 beginning of Erectus.

Since Erectus only left the two poor strata like at Swanscombe or El-Castillo/Spain, he should actually not have lasted longer than Neanderthal-may be one average life expectancy. I will now not go into the mechanism of mutation. All I want to remind you of is the undisputed sequence of interstratification and monostratification in the master stratigraphies. This allows for one solution only: Parents of the former developmental stage of man lived together with their own offspring in the same cave stratum until they died out. They were not massacred as textbooks have it:

monostrat.: only modern man's tools

interstrat.: Neanderthal man's and modern man's tools side by side

monostrat.: only Neanderthal man's tools

interstrat.: Neanderthal man's and Erectus' tools side by side

monotstrat.: only Erectus tools (deepest stratum for intelligent man)

The year figures certainly sound bewildering. Yet, so far nobody came up with any stratigraphy justifiably demanding more time than I tentatively assigned to the age of intelligent man. I always remind my critiques that one millennium is an enormous time span--more than from William the Conqueror to today's Anglo-World. To add a millenium to human history should always go together with sufficient material remains to show for it.

Looking like us more or less, and being in any way interchangable with us are of course different things. The recent DNA studies have basically explained the big mystery of there being no evidence of cross breeding between us and neanderthals, and eliminated the neanderthal as a plausible ancestor for modern man and, all other hominids being FURTHER removed from us than the neanderthal, that leaves us with no plausible evolutionary antecedent for modern man on the planet and the idea of modern man having evolved, pretty much in tatters.

78 posted on 07/21/2006 5:29:47 AM PDT by tomzz
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To: HowlinglyMind-BendingAbsurdity
>Why waste time piecing together DNA from 45,000-yr-old bones when there are living specimens [?]


79 posted on 07/21/2006 7:44:57 AM PDT by theFIRMbss
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To: Republican Wildcat

There are people who believe neanderthals are still living on earth. There are even more who believe this since last night's Art Bell Show.


80 posted on 07/21/2006 8:16:28 AM PDT by RightWhale (Repeal the law of the excluded middle)
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