Scientists achieve pancreatic tumour regression in breakthrough study

euro news ^ | 01 28 2026 | Rafael Salido

[yesthatjallen]

Pancreatic cancer is one of the most aggressive tumours with the worst prognosis, partly because of the rapid emergence of resistance to treatment. But a new study from the Spanish National Cancer Research Centre (CNIO) reveals that it is possible to eliminate pancreatic tumours in mice and prevent them from recurring using triple combination therapy.

"These studies open a way to design new combination therapies that can improve the survival of patients with pancreatic ductal adenocarcinoma," the authors said in a statement. "These results set the direction for the development of new clinical trials, it added.

The results, published in the scientific journal 'PNAS', show that simultaneously targeting three key points of the KRAS oncogene molecular pathway achieves long-lasting tumour regression. In Spain, more than 10,300 cases of this type of cancer are diagnosed each year, with a five-year survival rate of less than 10 percent.

The key to the breakthrough lies in avoiding the resistance that appears when the oncogene is blocked at a single point. The CNIO team combined an experimental KRAS inhibitor, a drug already approved for lung cancer, with a protein degrader, resulting in tumours disappearing without significant side effects in three different animal models.

Although the result could be a milestone in the fight against cancer, the study authors issued caution.

"We are not yet in a position to carry out clinical trials with triple therapy. The authors themselves warn that optimising this combination for patients will be a complex process, although they are confident that the finding will set the course for future trials," they said.

SNIP

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TOPICS: Health/Medicine; Local News; Weird Stuff
KEYWORDS: cancer; eussr; fourthreich; mice; pancreas; stoppostinginnews; tumor; tunor

[dfwgator]

Great news for mice.

[packagingguy]

I had a friend who died of pancreatic cancer. It’s good they found a possible cure but it’s too late for her.

[desertsolitaire]

I think the 5 year human survival rate, with treatment, used to be less than 2% so every little bit helps. Didn’t the late USSC Justice Ruth Baader Ginzberg live for a very long time after pancreatic cancerdiagnosis and treatment? As I recall, her pancreatic cancer was discovered very andmost unusually early, by accident, during another test or procedure. Usually pancreatic cancer is diagnosed late in the staging and not very treatable.

[butlerweave]

Pancreatic cancer bad stuff

[Bubba_Leroy]

Scientists have been curing every form of cancer in mice for many years. People not so much.

[Vermont Lt]

There are two main types of PC cancer. Cancer in the tail, which is what RBG and Steve Jobs had is very treatable and it doesnt spread nearly as fast. It has to do with the location of the tumor and its surroundings.

Pancreatic cancer in the head of the pancreas is right next to a couple of arteries and the digestive system. It is literally inches to the liver and there is a duct that connects to two systems. Tumors on head of the pancreas are the ones that spread fast (usually) and unless they are found really early, inoperable and hard to treat.

I don’t know about the mice kind.

[Tunehead54]

Health bump!

CM,

Do you have anything on this study?

Thanks.

😎

[plain talk]

Sounds promising. Good news.

[Organic Panic]

It killed my aunt in a year. Rough disease.

[Myrddin]

I have an old friend in the last throes of Stage 4 pancreatic cancer. It has obstructed his celiac artery and has induced cachexia. It is burning off his muscle mass at this point with little hope of reversal. He has been fighting it since early 2023. Lots of chemo and a whipple held it at bay, but it finally broke loose. At this point he is confident of celebrating Valentine's Day, but uncertain how much longer he can hold out. A couple days ago his doctor performed a celiac nerve block to allow him to get off the opioids. That was successful and just a little Tylenol is sufficient to get by. For now, he is satisfied with palliative care and trying to avoid going to hospice.

I read this thread in hopes that there was something to help my friend. It's still mouse research, so it won't be an option.

[ConservativeMind]

I don't, yet.

I think I know the KRAS inhibitor, but I don't know the protein degrader.

This could be available to people with no other options left, though.

Thank you, President Trump!

[Robert357]

bump for pancreatic cancer reference

[misterdarcey]

I can hear Norm MacDonald saying “You know, mice must be the healthiest creatures on earth by now...”