Posted on 11/28/2025 9:50:18 PM PST by Red Badger
A new version of Ozempic is in the works for next year and is subject to FDA approval
The manufacturers of Ozempic and Mounjaro are planning to launch a new weight loss method in 2026.
While Ozempic remains a GLP-1 medicine for adults with Type-2 diabetes, and not a weight loss drug, Mounjaro - the brand name for tirzepatide - can be prescribed for weight-loss via the NHS.
These drugs typically come in jab form, but it appears the new era of medicine could be upon us fairly soon.
Mounjaro's manufacturer, Eli Lilly, announced in September that it was hoping to 'offer a convenient, once-daily pill that can be scaled globally'.
Named 'Orforglipron', it can be 'taken once per day without food and water restrictions'.
While it remains in development, initial tests showed that it 'lowered weight by an average of 10.5 per cent (22.9 lbs) compared to 2.2 per cent (5.1 lbs) with a placebo', Eli Lilly explained.
Kenneth Custer, executive vice president at Eli Lilly, added: "With these positive data in hand, we are moving with urgency toward global regulatory submissions to potentially meet the needs of patients who are waiting."
It comes after Eli Lilly said that its experimental pill, orforglipron, outperformed Novo Nordisk’s oral semaglutide in a year-long trial.
At the highest dose, orforglipron delivered greater weight loss - an average 9.2 percent (about 19.7lbs) compared with Ozempic's 5.3 percent (about 11 lbs).
When including all participants, Lilly’s pill produced 8.2 percent weight loss versus 5.3 percent for semaglutide.
“For the majority of patients, this could be the main medicine that they need to control their Type 2 diabetes as well as their obesity,” Eli Lilly Chief Scientific Officer Dan Skovronsky
Ozempic.
Drugmakers had hoped the oral version of the drug may have had a new use in the form of slowing down the progression of Alzheimer’s - however, it was reported that an oral version failed to do so in two major trials.
The Danish drugmaker said patients taking the pill saw no meaningful reduction in disease advancement, which put a hold on expectations that the bestselling diabetes medication might have a new use.
As many companies are rushing to bring an anti-obesity pill to market, it seems there would be demand for it, particularly for people who don't like needles.
“With this newer generation of medications, we’re not just focusing on weight loss,” David Lau, an endocrinologist and professor emeritus at the University of Calgary Cumming School of Medicine told The Washington Post.
“We’re talking about changes beyond what you see on the scale.”
Despite all the optimism, the drugs are still subject to FDA approval.
LADbible Group has contacted Novo Nordisk and Eli Lilly for comment.
Dear FRiends,
We need your continuing support to keep FR funded. Your donations are our sole source of funding. No sugar daddies, no advertisers, no paid memberships, no commercial sales, no gimmicks, no tax subsidies. No spam, no pop-ups, no ad trackers.
If you enjoy using FR and agree it's a worthwhile endeavor, please consider making a contribution today:
Click here: to donate by Credit Card
Or here: to donate by PayPal
Or by mail to: Free Republic, LLC - PO Box 9771 - Fresno, CA 93794
Thank you very much and God bless you,
Jim
for some who by various reasons, get their body chemistry really wacky, “just exercise and don’t eat snacks” is not always that answer. Thyroid issues play in as well as other medical, time of eating, or genetic things can play in.
Eating less, but eating it late in the day (even if healthier foods) can signal the body to store as fat and burn muscle to fulfill adequate nutrient needs to maintain life. a person may lose weight but not in the way that is healthy for a body.
The long term benefits for getting obesity under control are counted in the tens of billions of dollars. There will be fewer knee replacements, heart attacks, kidney failures, and a whole host of other related maladies.
Those costs are coming out of your pocket.
If a pill or shot can safely reduce those things…why would anyone want to stop that.
If it was only a matter of “just eat less”, this wouldn’t be an issue.
Go to Walmart and hand this stuff out like candy.
I agree. Too many people are undisciplined, weak, and lazy.
Beat me to it! Portion control and move - don’t have to run, walking is great. Although aerobic exercise burns off calories more quickly. So once these folks have lost the desired weight and gone off the drug, then they do not have the proper lifestyle to maintain the weight.
Right!
Right! Some time after my second (and last) child was born, I hopped on the scale. The weight was the same as when I was full term with my second son (I had gained the 30 pounds recommended by my doc). Hmmmm, I thought, there isn’t a baby in my body, that’s fat! So I ran and exercised and dieted. It has served me well for the past 40 years!
More drugs to make the pharmies richer, but no exercise and a lousy diet is the American obese way!
Like Tony Dungy once said about football players coming to Summer Camp with a few extra pounds - “If you don’t feel hunger, you won’t lose weight”. And this was about prime of life professional athletes.
Then, a drug that should only be used for the seriously obese to get started, they use a top-seeded professional tennis player to hawk their poison.
And what exactly would those changes be?
I'm just going to say it out loud: any drug these drug pushers rush to market like this is NOT going to have positive long-term effects.
Receipt: Every damn' Covid jab & pill.
Exercise? Don’t snack? Impossible. You may as well tell me to stop drinking.
“And what exactly would those changes be?”
Just ignore that third eye growing in your forehead.............
they do have horrible side effects, and are well known.
Started low dose Zepbound on 11/1 and I’m down 9 lbs in 28 days. The next 28 days will be the 5mg dose. Only side effect is constipation which has been managed with stool softener. Best benefit is I don’t think about food all the time; and when I eat, portion control is much easier. I’m more likely to choose healthier options that take longer to prepare since I’m not starving all the time. Clothes are starting to fit better. To me, the cost/benefit is positive.
I’m not worried about long term side effects since I’m going to die of something. Being overweight is a death sentence itself.
Averted disease related costs are going to be at least 4-5 billion and net savings to Medicare of hundreds of millions as the drug discounts come online 2026 or 2027.
After all these “miracle drugs” (remember Fen-Phen??) it all boils down to this:
Eat less and exercise more!
There is no getting around that.
Put down the moon pie and the RC cola. 🙄
I heard a comedian say something hilarious (to me at least), and somewhat profound:
“Did you notice that when Ozempic came out you stopped hearing about body positivity?”
You are extremely lucky and in the minority then. I’ve fasted, dieted, protien only, protien and veggies, no snacks… and I am still hungry, lose very little weight, and essentially end up staying about the same weight.
As weird as it sounds though, I got diagnosed with diabetes and I’ve been doing high protien and low carbs and it has reduced my inflammation so my joints feel better than they have in years.
While that list is intimidating, there is a drug advertised on TV for some condition which has a side effect of having your limbs fall off ...
Once again I would like to say that it's like the beginning of a bad "Sci-Fi Channel" move.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.