Posted on 11/28/2025 9:50:18 PM PST by Red Badger
A new version of Ozempic is in the works for next year and is subject to FDA approval
The manufacturers of Ozempic and Mounjaro are planning to launch a new weight loss method in 2026.
While Ozempic remains a GLP-1 medicine for adults with Type-2 diabetes, and not a weight loss drug, Mounjaro - the brand name for tirzepatide - can be prescribed for weight-loss via the NHS.
These drugs typically come in jab form, but it appears the new era of medicine could be upon us fairly soon.
Mounjaro's manufacturer, Eli Lilly, announced in September that it was hoping to 'offer a convenient, once-daily pill that can be scaled globally'.
Named 'Orforglipron', it can be 'taken once per day without food and water restrictions'.
While it remains in development, initial tests showed that it 'lowered weight by an average of 10.5 per cent (22.9 lbs) compared to 2.2 per cent (5.1 lbs) with a placebo', Eli Lilly explained.
Kenneth Custer, executive vice president at Eli Lilly, added: "With these positive data in hand, we are moving with urgency toward global regulatory submissions to potentially meet the needs of patients who are waiting."
It comes after Eli Lilly said that its experimental pill, orforglipron, outperformed Novo Nordisk’s oral semaglutide in a year-long trial.
At the highest dose, orforglipron delivered greater weight loss - an average 9.2 percent (about 19.7lbs) compared with Ozempic's 5.3 percent (about 11 lbs).
When including all participants, Lilly’s pill produced 8.2 percent weight loss versus 5.3 percent for semaglutide.
“For the majority of patients, this could be the main medicine that they need to control their Type 2 diabetes as well as their obesity,” Eli Lilly Chief Scientific Officer Dan Skovronsky
Ozempic.
Drugmakers had hoped the oral version of the drug may have had a new use in the form of slowing down the progression of Alzheimer’s - however, it was reported that an oral version failed to do so in two major trials.
The Danish drugmaker said patients taking the pill saw no meaningful reduction in disease advancement, which put a hold on expectations that the bestselling diabetes medication might have a new use.
As many companies are rushing to bring an anti-obesity pill to market, it seems there would be demand for it, particularly for people who don't like needles.
“With this newer generation of medications, we’re not just focusing on weight loss,” David Lau, an endocrinologist and professor emeritus at the University of Calgary Cumming School of Medicine told The Washington Post.
“We’re talking about changes beyond what you see on the scale.”
Despite all the optimism, the drugs are still subject to FDA approval.
LADbible Group has contacted Novo Nordisk and Eli Lilly for comment.
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Just exercise and don’t snack. It’s doable.
I would have concerns that all these new weight-loss drugs are going to have some nasty long-term side effects that won’t surface right away. Remember, kids, that cigarettes were once marketed not necessarily unreasonably as a weight-loss aid— overtly (”Reach for a Lucky instead of a sweet”) and later more subtly (Virginia SLIMS).
How about just eating less? Anyone can and will lose weight with calorie restriction.
From the 1940 through the end of the 1960s, with the best will in the world, doctors were prescribing diethylstilbestrol to prevent miscarriage, premature labor and just about every other pregnancy problem under the sun.
Turned out it did not work.
But it did give the children exposed in utero some lovely parting gifts. Like low fertility and raised cancer rates.
And it looks like these gifts are being passed on to the third generation.
I am not saying don't take it. I am saying be careful.
And if you have the possibility of becoming or of making someone pregnant be really really careful.
Some actions have really long shadows.
“Orforglipron” — I would have loved to have been in the Naming Committee meeting that came up with that tongue twister!
“Oh For Crying Out Loud”
“Wait a sec! I think you’ve got something there. Let’s work it a bit!”
“Or forget I said anything about porn...er ‘pron’”
“Keep it going folks, we’ve got something we can work with here!”
A couple of women in town weighed well into the 300’s and for lunch, they would br8ng in a cake apiece and sit and eat it all- after a huge lunch. Eventually they began walking and dieting, and did really well. Not sure if they ever relapsed or not though.
Simple math really... the less calories you take in, the more weight you will lose. I cznt even imagine ehzt their calorie load was when they were eating enough food for 3 people.
The world’s strongest man contests have contestsnts that eat tremendous amounts of calories per day, but they are working a lof of that off, and they need that many to keep their bulk up to turn to muscle. But these are folks that dead-lift cars for fun.
I think you’re right. Anything that is manipulating multiple endocrine organs is going to eventually be found to cause endocrine problems…..maybe even endocrine cancers. Just my opinion.
So far, they will only admit that they cause kidney stones.
But they also warn that GLP-1 receptor agonists (GLP-1 RAs) should not be taken by individuals with a personal or family history of multiple endocrine neoplasia type 2 (MEN2) or medullary thyroid carcinoma (MTC) due to an increased risk of thyroid cancer associated with these conditions. There’s a reason for that.
Or could just eat less...
I have a hard time gaining weight. Hard to relate to taking a drug to loose weight.
I think it was Sharon Osborne who said that when she was on Ozempic the side effects were “horrific” — for her, anyhow.
whats the goal?
clothes hangers with hair?
Sharon Osborne who said that when she was on Ozempic the side effects were “horrific”
Most troubling for her.....she kept losing weight even when she stopped taking it.
Kidney stones and gallbladder issues has nothing to do with Ozempic. It is strictly a matter of rapid weight loss. It’s the nature of stopping the constant output of bile when you stop eating so much fat and crap.
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