How This Slimy Sea Creature Could Revolutionize Cancer Treatments

Fisherman holding a pair of sea cucumbers. (Photo by The Pirates on Shutterstock)

Scientists Discover Sea Cucumbers Contain Powerful Compound That Fights Aggressive Tumors

* Scientists found that a compound from sea cucumbers can block Sulf-2, an enzyme that helps cancer cells spread throughout the body

* Smaller fragments of the sea cucumber extract work just as well as the full compound but cause fewer side effects

* The compound targets cancer cells specifically without broadly attacking healthy cells like traditional chemotherapy

UNIVERSITY, Miss. — Scientists at the University of Mississippi have discovered that a slimy sea cucumber might hold the secret to stopping cancer cells from spreading throughout the body. It’s a major breakthrough that could transform how doctors treat some of the most aggressive tumors.

Led by Dr. Vitor Pomin, an associate professor from the school’s Department of BioMolecular Sciences, researchers found that a sugar-like compound extracted from sea cucumbers can effectively shut down an enzyme called Sulf-2, which acts like a cellular troublemaker in cancer patients. When this enzyme goes into overdrive, it helps tumors grow faster, spread to other parts of the body, and resist traditional treatments. Sulf-2 has been linked to breast, lung, pancreatic, and head and neck cancers.

The sea cucumber compound outperformed existing treatments in laboratory tests. Even better, smaller pieces of this compound kept their cancer-fighting abilities while potentially causing fewer side effects, addressing one of the biggest problems in cancer treatment today.

“Research in drug discovery and development of natural products is mostly focused on terrestrial compounds,” Dr. Pomin tells StudyFinds’ Editor-in-Chief Steve Fink. “Our findings that marine-derived compounds, particularly the anticancer sea cucumber compound, indicate that the marine biodiversity may be hiding medicinal compounds, which are currently underexplored due to the lower accessibility to the sea environment and the dominance of research interest on terrestrial sources. The marine environment should be treated as a unique and rich resource of novel and potent drugs.”

Sea cucumber A sugar compound found in sea cucumbers could hold the key to stopping the spread of cancer, according to a recent UM-led study published in Glycobiology. (CREDIT

Sea cucumbers, those blob-like creatures found on ocean floors, naturally produce complex sugar molecules as part of their defense systems. Scientists are increasingly mining these marine organisms for medical compounds that could help humans fight disease.

Researchers tested various ocean-derived compounds against the problematic Sulf-2 enzyme. The extract from Holothuria floridana, a species of sea cucumber, emerged as the clear winner among all tested materials.

“The sea cucumber compound belongs to a class of molecules named glycosaminoglycans. The Sulf-2 natural substrate in our body during cancer progress also belongs to this class of compounds,” explains Dr. Pomin.

The compound works differently than most cancer treatments. Instead of competing directly with the enzyme’s normal functions, it changes how the entire enzyme operates. This type of blocking often produces more stable and predictable effects, making it potentially more useful as a treatment.

Sulf-2 normally acts like a molecular editor, modifying sugar chains on cell surfaces to control how cells communicate with each other. In healthy tissue, this editing process helps regulate cell growth and movement. But cancer hijacks this system, turning Sulf-2 into an accomplice that helps tumors thrive.

The enzyme becomes overactive in many types of cancer, editing cellular messages in ways that promote tumor growth and the spread of cancer to distant parts of the body. Previous attempts to develop Sulf-2 blockers have struggled with effectiveness and harsh side effects.

Sea cucumbers carry a compound that could potentially work alongside chemotherapy in stopping cancer in the future. (Photo by ChristianChan on Shutterstock)

Computer simulations revealed exactly how the sea cucumber compound works. Its unique structure allows it to latch onto specific regions of the Sulf-2 enzyme and jam its machinery.

“The sea cucumber sugar shows chemical differences and similarities when compared to the regular Sulf-2 substrate,” Dr. Pomin tells StudyFinds. “This makes the marine sugar a competitive inhibitor for the cancer-related enzyme, resulting therefore in a decrease of the cancer progression.”

One of the most promising discoveries involved breaking the large sea cucumber molecules into smaller fragments. The research team found that pieces around one-seventh the size of the original compound retained most of their cancer-fighting power.

Smaller drug molecules typically mean better news for patients. They often cause fewer side effects, are easier to manufacture, and can be modified to improve their effectiveness. The team’s experiments showed that medium-sized fragments maintained strength while the tiniest pieces lost their effectiveness.

Laboratory tests confirmed that the sea cucumber compounds could effectively interfere with the enzyme’s normal targets. Blood clotting presented another crucial consideration. Many marine-derived compounds increase bleeding risk, but the smaller sea cucumber fragments showed minimal impact on blood clotting while keeping their anti-cancer properties intact.

Previous studies showed that the sea cucumber compound could reduce cancer cell invasion in laboratory models of head and neck cancer, substantially reducing cancer aggressiveness.

The research, published in Glycobiology, identified specific structural features that make the compound effective. Scientists could use this knowledge to design synthetic versions that might work even better than the natural compound.

Current cancer treatments often fail because tumors develop resistance or because patients can’t tolerate the toxic side effects. The sea cucumber compound’s targeted approach and milder side effect profile suggest it could potentially work alongside existing treatments to improve patient outcomes. Rather than broadly attacking cellular processes like chemotherapy, this marine extract specifically targets the problematic enzyme while potentially leaving healthy cells alone.

“They could be used either as a coadjutant in very aggressive cancer cases or as the first line of treatment in initial and mild cases,” says Dr. Pomin. “The sea cucumber compound is natural and non-toxic. It is part of the Asian cuisine that uses sea cucumbers as an ingredient of their diets. Chemotherapeutic agents are, on the other hand, well-known to be highly cytotoxic and aggressive to patients. The sea can comprise a greener, safer, and promising resource of less toxic anticancer agents.”

The discovery demonstrates that some of medicine’s most powerful weapons against cancer may be hiding in ocean creatures. As researchers continue exploring marine life for new medicines, compounds like this sea cucumber extract could revolutionize cancer treatment by offering more precise and less toxic alternatives to current therapies.

Of course, there’s still plenty of work to be done before turning this compound into an actual drug.

“We still need to perform some pre-clinical studies using animal models before ultimately moving with this compound to clinical trials in humans. This approach will offer the principal conclusions before officially launching the marine compound in the pharmaceutical market,” says Dr. Pomin. “In parallel to these clinical studies, routes of chemical synthesis must be designed and proposed. This will offer an alternative to overcome the limited yields of the marine compound as a natural product.

“Additionally, we must conduct some structural investigations of the polymeric nature of the sea cucumber compound in terms of chain organization and domain architecture,” he continues. “This analytical study will offer the basis to uncover the structural heterogeneity of the sea cucumber compound at the atomic and molecular level as well as the specific structural sequences responsible for interaction and inhibition of Sulf-2.”

The researchers tested various sulfated compounds from marine sources against the enzyme Sulf-2 using multiple laboratory techniques. They used two different enzyme activity assays to measure how well compounds could block Sulf-2 function. The team also employed surface plasmon resonance to measure binding strength, mass spectrometry to identify where compounds attach to the enzyme, and computer simulations to model molecular interactions. They tested compounds from sea cucumbers, sea urchins, and commercially available sugar molecules, comparing their effectiveness against Sulf-2.

The sea cucumber compound HfFucCS emerged as the most effective Sulf-2 inhibitor among all tested compounds, with an IC50 value of 0.23 μg/mL in initial screening. Smaller fragments of this compound (particularly Fr1 and Fr2, around 7,500 molecular weight) maintained similar effectiveness while showing reduced side effects. The compound demonstrated non-competitive inhibition, meaning it changes enzyme function rather than competing with natural substrates. The research identified that specific structural features, particularly the 3,4-disulfated fucose pattern, are crucial for the compound’s effectiveness.

The study was conducted entirely in laboratory settings using purified enzymes and cell culture systems, so the results may not translate directly to human patients. The researchers noted that more work is needed to understand how the compound behaves in living organisms and whether it can be developed into an effective treatment. Some regions of the Sulf-2 enzyme couldn’t be analyzed due to technical limitations, potentially missing important binding sites. The study also didn’t test long-term effects or potential interactions with other medications.

This research was supported by the National Institutes of Health grants 1P20GM130460-01A1–7936, R01CA238455, P30CA51008, and S10OD028623, as well as University of Mississippi funding. One author disclosed a financial interest in GenNext Technologies, Inc., which commercializes research instruments. The funding agencies had no role in study design, data collection, or publication decisions.

This study was published in Glycobiology, volume 35, article cwaf025, in 2025. The paper was titled “Heparan-6-O-endosulfatase 2, a cancer-related proteoglycan enzyme, is effectively inhibited by a specific sea cucumber fucosylated glycosaminoglycan.” The research was conducted by an international team led by corresponding author Dr. Vitor H. Pomin at the University of Mississippi, with collaborators from Georgetown University and other institutions.

Available in 5 years, along with the cure for Baldness, Flying Cars, the release of the Epstein files, etc.

2 posted on 07/09/2025 11:15:37 AM PDT by qam1 (There's been a huge party. All plates and the bottles are empty, all that's left is the bill to pay)

I recall a chinese coworker ordering sea cucumber at a restaurant and having to explain to others at the table several times ‘not a vegetable!’

It was at one of those restaurants where if you do not have any chinese in your party you get the 1 page bland sugary glop menu vs the 5 page menu.

Yes and they all want funding for projects give until it hurts motto.

5 posted on 07/09/2025 11:39:05 AM PDT by Honorary Serb (Kosovo is Serbia! Free Srpska! Abolish ICTY!)

As long as I don’t have to eat it.

6 posted on 07/09/2025 1:06:59 PM PDT by libertylover (The HBM (Has Been Media) is almost all AGENDA-DRIVEN, not-truth driven.)

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