Coffee-based approach yields promising results in ovarian cancer trial (Artemisia annua)

Medical Xpress / University of Kentucky / Society of Gynecologic Oncology annual meeting ^ | April 4, 2025 | Elizabeth Chapin / Jill Kolesar, Pharm.D.

[ConservativeMind]

Researchers presented promising results from an early-stage clinical trial investigating a unique coffee-based approach to ovarian cancer maintenance therapy.

The study examined ArtemiCafe Decaf, a commercially available decaffeinated coffee product containing a controlled dose of Artemisia annua, a plant that has been used medicinally for centuries and is known for its antimalarial properties. Recent laboratory research has shown the plant may also have anti-cancer properties.

Preliminary findings of the phase 1 trial show that ArtemiCafe Decaf is safe and well tolerated by patients at a dose of four cups daily. Additional patient follow-up is needed to determine its efficacy in the treatment of ovarian cancer.

"This trial represents an important step in exploring how Artemisia annua might help patients with ovarian cancer after they complete standard treatments," said Frederick Ueland, M.D. "Finding a well-tolerated maintenance therapy that could potentially delay or prevent recurrence would be transformative for ovarian cancer care."

Previous laboratory studies conducted by researchers demonstrated that artesunate, a compound derived from the Artemisia annua plant, showed strong anti-cancer activity against ovarian cancer cells at clinically achievable concentrations.

ArtemiCafe Decaf is currently being evaluated in a phase 2 clinical trial at Markey, which is focused on maintenance therapy for prostate cancer patients.

Kentucky also has a special connection to this research, as it is currently the only state growing substantial amounts of Artemisia annua. The Kentucky Tobacco Research and Development Center at the UK Martin-Gatton College of Agriculture, Food and Environment currently grows the plant on the university's Spindletop Farm; researchers across UK use the yields of that farm. ArtemiLife products use Artemisia annua plants grown at two Kentucky farms in Georgetown and Lancaster.

[ConservativeMind]

ArtemiCafe Decaf is available from ArtemiLife, which uses plants grown in Kentucky, but something similar from elsewhere may work similarly, due to the plant being more commonly available.

It appears to fight off ovarian cancer.

[ConservativeMind]

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[gundog]

I drink lots of coffee, and ovarian cancer is the furthest thing from my mind.

[E. Pluribus Unum]

Also known as wormwood.

https://www.amazon.com/Natural-Artemisia-Wormwood-Herbal-Leaves/dp/B087QLT163/

[BipolarBob]

Oh no. I don’t want to get back on the coffee enemas again. Darn it. But I also don’t want overian cancer. Come to think of it, I don’t think I have ovaries.

[BlackVeil]

It looks like a good product. I always have decaf coffee from 4pm onwards, for the sake of a peaceful night’s sleep.

[Uncle Miltie]

I approve of artemisia.

[sauropod]

bkmk