Posted on 03/24/2025 9:28:54 PM PDT by ConservativeMind
Researchers have found that oral cholecalciferol in doses of 100,000 IU every two weeks significantly reduced disease activity in clinically isolated syndrome and early relapsing‑remitting multiple sclerosis.
Multiple sclerosis typically starts with an acute episode involving the central nervous system, such as inflammation of the optic nerve, the spinal cord, or brainstem syndromes. This combination of initial signs is termed a clinically isolated syndrome (CIS), although CIS does not always convert to MS.
In the D‑Lay MS randomized clinical trial, investigators conducted a parallel, double‑blind, placebo‑controlled study comparing high‑dose cholecalciferol versus placebo in untreated CIS.
Eligibility criteria included adults aged 18–55 with CIS onset within 90 days, serum vitamin D <100 nmol/L, and MRI evidence of dissemination in space or ≥2 lesions plus positive oligoclonal bands.
A total of 316 participants were randomized 1:1 to receive oral cholecalciferol 100,000 IU (n=163) or matching placebo (n=153) every two weeks for 24 months. The primary outcome was disease activity (first relapse or new/contrast‑enhancing MRI lesions). Of the 316 randomized, 303 (156 vitamin D; 147 placebo) received at least one dose and 288 completed the full 24‑month follow‑up.
Disease activity occurred in 94 of 156 patients (60.3%) receiving vitamin D versus 109 of 147 (74.1%) receiving placebo (HR, 0.66), and median time to disease activity was significantly longer with vitamin D (432 vs. 224 days).
All three secondary MRI outcomes favored vitamin D: overall MRI activity (57.1% vs. 65.3%; HR, 0.71), new or enlarging T2 lesions (46.2% vs. 59.2%; HR, 0.61), and contrast‑enhancing lesions (18.6% vs. 34.0%; HR, 0.47).
Oral high‑dose cholecalciferol reduced disease activity in CIS and early relapsing‑remitting MS. These findings support further investigation, including pulse high‑dose vitamin D as an add‑on therapy. High‑dose vitamin D may offer an inexpensive, well‑tolerated option, especially where access to standard disease-modifying therapies is limited.
(Excerpt) Read more at medicalxpress.com ...
“Disease activity occurred in 94 of 156 patients (60.3%) receiving vitamin D versus 109 of 147 (74.1%) receiving placebo (HR, 0.66), and median time to disease activity was significantly longer with vitamin D (432 vs. 224 days).”
“All three secondary MRI outcomes favored vitamin D: overall MRI activity (57.1% vs. 65.3%; HR, 0.71), new or enlarging T2 lesions (46.2% vs. 59.2%; HR, 0.61), and contrast‑enhancing lesions (18.6% vs. 34.0%; HR, 0.47).”
Hmmmmm......what about Vit D toxicity?
Early symptoms of vitamin D toxicity are loss of appetite, nausea, and vomiting, followed by weakness, nervousness, and high blood pressure.
I take 10,000 IU a day, I notice a big change in my attitude and energy. I could use the loss of appetite😜 I don’t think 10,000 is that big of a deal. I definitely am motivated to get off the couch and get out of the house now.
Supposedly most, if not all MS victims, after death, who get a spinal tap have parasites in their spinal fluid.
For these patients, it was well-tolerated and did not cause any toxicity issues.
It might be due to being so chronically low in Vitamin D, or missing the ability to properly make or use it.
Whoa! Mine is 50,000IU an dose is 1 per week. My last D number was in the 80’s which is really high. Good high I mean.
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My sister-in-law recently had a kidney stone attack, and ended up in the hospital. They gave her medication to help disintegrate it, and sent her home. When it didn’t dissolve or pass, she ended up having it zapped. When the hospital doctor discovered she’d been taking high doses of Vitamin D for a long time, he told her that that is likely what caused the kidney stone to develop.
I find it criminal that doctors hand out these megadoses of rat poison and never mention a word about hypercalcemia. I know exactly what it feels like big time. We all could use some more calcium in our arteries, right?
What happens when calcium levels are high?
https://www.medicalnewstoday.com/articles/322012
“Extremely high levels of calcium in the blood can become life threatening.”
No shinola!
***When the hospital doctor discovered she’d been taking high doses of Vitamin D for a long time, he told her that that is likely what caused the kidney stone to develop.***
In my experience, most doctors have absolutely NO clue about vitamin supplements, especially vitamin D3. Anyone who does his own research will learn that vitamin D toxicity is almost non-existent.
I have taken over 10,000 IU per day for years and years with absolutely NO ill-effect, but have excellent health for someone who is 80+.
Excess vitamin d can create a vitamin k deficiency and that can lead to tooth loss.
One shouldn’t try to get vitamin d higher than 32 ng/ml. There is more kidney stones among people with 50 ng/ml.
Here is a study about vitamin d and kidney stones:
Increased Incidence of Nephrolithiasis (N) in Lifeguards (LG) in Israel
https://link.springer.com/chapter/10.1007/978-1-4615-9167-2_51
A recent blood test showed my Vitamin D is too low. I got a script yesterday for 50,000 IU once a week.
Supplementing with Vitamin K2 solves that problem. It moves calcium from soft tissues to bones, where it belongs. Meanwhile D is involved in hundreds of processes in your body, and 32 is a low level that is far from optimum. Most people should be at least at 50, and being at 80 would be better for most people. But you MUST get more K2. Fortunately, more companies are making a combined product, so it’s easy to get both.
Its a coupla reely small pills, or a large glass of ice cold bovine Vit D milk.
The evidence that 50 ng/ml is too high is that lifeguards with that level have more kidney stones. I posted a study above. What is the evidence that 50 ng/ml is better than 32 ng/ml?
I read that if you take more than 4,000 IU D3 daily, you need to also take K2 so that calcium is used correctly and does build up on arteries. The MK-7 type of D3 is recommended.
We take 5,000 in winter and 2,000 in summer with lots of sunshine. However, we’ve also read the skin’s ability to produce D3 decreases in seniors and as people age.
Same thing happened to me
My youngest son was using whey protein and ended up with a kidney stone too. I took 50,000 IU of Vitamin D once a week at my endocrinologist's direction, and after some years, he ended up taking me off of it because my numbers were too high. I have an over-active para-thyroid too, that produces more calcium than my body needs. The number for that is always high. Sucks to get old.
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