Posted on 03/13/2025 3:31:31 PM PDT by ConservativeMind
Researchers have shown how a low-carbohydrate diet can worsen the DNA-damaging effects of some gut microbes to cause colorectal cancer.
They found that a unique strain of E. coli bacteria, when paired with a diet low in carbs and soluble fiber, drives the growth of polyps in the colon, which can be a precursor to cancer.
A low-carb diet paired with a strain of E. coli that produces the DNA-damaging compound colibactin—led to the development of colorectal cancer.
The researchers found that a diet deficient in fiber increased inflammation in the gut and altered the community of microbes that typically reside there, creating an environment that allowed the colibactin-producing E. coli to thrive.
They also showed that the mice fed a low-carb diet had a thinner layer of mucus separating the gut microbes from the colon epithelial cells. The mucus layer acts as a protective shield between the bacteria in the gut and the cells underneath. With a weakened barrier, more colibactin could reach the colon cells to cause genetic damage and drive tumor growth. These effects were especially strong in mice with genetic mutations in the mismatch repair pathway that hindered their ability to fix damaged DNA.
Defects in DNA mismatch repair are frequently found in colorectal cancer, which is the fourth-most commonly diagnosed cancer.
Their findings suggest that avoiding a low-carb diet or taking a specific antibiotic treatment to get rid of the colibactin-producing bacteria could help reduce their risk of colorectal cancer.
Thakur is keen to follow up on an interesting result from their study showing that the addition of soluble fiber to the low-carb diet led to lower levels of cancer-causing E. coli, less DNA damage and fewer tumors.
(Excerpt) Read more at medicalxpress.com ...
The best way we have found to regularly get a lot is from these new keto bread items you can find.
We prefer Hero and Sola bread products, but others are also good.
Try for 28 grams a day for women and 38 grams a day for men.
Ah geez. There’s no way to win!
Cuz, in the end, if you eat you die!
Just need to include your greens and other veggies.
Can still keep your glycemic load way down.
Eat the keto bread!
Everyone I know on low carb takes solulable fiber.
Fiber is a carbohydrate you can’t digest. These storys are just scare mongering.
“Ah geez. There’s no way to win!”
Think of these ‘studies’ as we do for Global Warming. Someone funds them, in this case a bunch of Flaming Meat-Hating Leftists (that being the Canadian government), and therefore the only acceptable ‘result’ is what they published.
when paired with a diet low in carbs and soluble fiber
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Maybe it’s not the carbs, it’s the fiber. Some foods contain soluble fiber, too.
https://www.healthline.com/nutrition/foods-high-in-soluble-fiber
sadly true
Totally true. I eat more fiber while on a low carb diet than most people that are not on any diet.
It's a mouse study. Is there any focus on fusobacterium nucleatum? (there is one cite) And what's in the high fat diet would need scrutiny, because with rare exception, lab rodent chows tend to be metabolic disasters.
Which GEM Project is this?
How can there be Keto bread?
I am wondering about something...
Our ancestors - way back - ate mostly meat and fish, and didnt eat “fiber” - it wasn’t available year round.
Why haven’t the Inuit and other modern tribes all died off? They didn’t/dont consume fiber, nor do other groups, like the Masai in Africa. They arent all dienig from cancer the last time I checked?
I think this is “horse puckey research” with an agenda. But, I could be wrong, of course.
I am calling this BS. Maybe in 1 person in 10,000. Not for the rest of us for whom a low carb diet is extremely beneficial.
Tastes like rubber no thanks
Thanks for posting. I am a huge fan of Sola bread. Tastes good and has lots of fiber. Does not spike blood glucose.
Oats contain a specific type of soluble fiber called beta-glucan. Beta-glucan promotes healthy gut bacteria and intestinal health. Oatmeal is cheap! Adult men should aim for 38 grams of fiber every day.
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