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How a low-carb diet could drive colorectal cancer development
Medical Xpress / University of Toronto / Nature Microbiology ^ | March 3, 2025 | Betty Zou / Bhupesh Kumar Thakur et al

Posted on 03/13/2025 3:31:31 PM PDT by ConservativeMind

Researchers have shown how a low-carbohydrate diet can worsen the DNA-damaging effects of some gut microbes to cause colorectal cancer.

They found that a unique strain of E. coli bacteria, when paired with a diet low in carbs and soluble fiber, drives the growth of polyps in the colon, which can be a precursor to cancer.

A low-carb diet paired with a strain of E. coli that produces the DNA-damaging compound colibactin—led to the development of colorectal cancer.

The researchers found that a diet deficient in fiber increased inflammation in the gut and altered the community of microbes that typically reside there, creating an environment that allowed the colibactin-producing E. coli to thrive.

They also showed that the mice fed a low-carb diet had a thinner layer of mucus separating the gut microbes from the colon epithelial cells. The mucus layer acts as a protective shield between the bacteria in the gut and the cells underneath. With a weakened barrier, more colibactin could reach the colon cells to cause genetic damage and drive tumor growth. These effects were especially strong in mice with genetic mutations in the mismatch repair pathway that hindered their ability to fix damaged DNA.

Defects in DNA mismatch repair are frequently found in colorectal cancer, which is the fourth-most commonly diagnosed cancer.

Their findings suggest that avoiding a low-carb diet or taking a specific antibiotic treatment to get rid of the colibactin-producing bacteria could help reduce their risk of colorectal cancer.

Thakur is keen to follow up on an interesting result from their study showing that the addition of soluble fiber to the low-carb diet led to lower levels of cancer-causing E. coli, less DNA damage and fewer tumors.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: cancer; colon; coloncancer; colorectal; lowcarbdiet; mucus
Soluble fiber is helpful for everyone.

The best way we have found to regularly get a lot is from these new keto bread items you can find.

We prefer Hero and Sola bread products, but others are also good.

Try for 28 grams a day for women and 38 grams a day for men.

1 posted on 03/13/2025 3:31:31 PM PDT by ConservativeMind
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To: Mazey; ckilmer; goodnesswins; Jane Long; jy8z; ProtectOurFreedom; matthew fuller; telescope115; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20 - 25% fewer pings) or “Everything” list.

2 posted on 03/13/2025 3:31:58 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

Ah geez. There’s no way to win!


3 posted on 03/13/2025 3:36:38 PM PDT by Lazamataz (I'm so on fire that I feel the need to stop, drop, and roll!)
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To: Lazamataz

Cuz, in the end, if you eat you die!


4 posted on 03/13/2025 3:43:05 PM PDT by milagro (There is no peace in appeasement! Thereon)
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To: ConservativeMind

Just need to include your greens and other veggies.

Can still keep your glycemic load way down.


5 posted on 03/13/2025 3:45:01 PM PDT by 9YearLurker
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To: Lazamataz

Eat the keto bread!


6 posted on 03/13/2025 3:49:44 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

Everyone I know on low carb takes solulable fiber.
Fiber is a carbohydrate you can’t digest. These storys are just scare mongering.


7 posted on 03/13/2025 3:50:05 PM PDT by Varda
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To: Lazamataz

“Ah geez. There’s no way to win!”

Think of these ‘studies’ as we do for Global Warming. Someone funds them, in this case a bunch of Flaming Meat-Hating Leftists (that being the Canadian government), and therefore the only acceptable ‘result’ is what they published.


8 posted on 03/13/2025 3:56:04 PM PDT by BobL (The people who hate Trump demand that you hate Russia)
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To: ConservativeMind

when paired with a diet low in carbs and soluble fiber
~~~~~~~~~~~~~~~~~~~~~~~~~~

Maybe it’s not the carbs, it’s the fiber. Some foods contain soluble fiber, too.
https://www.healthline.com/nutrition/foods-high-in-soluble-fiber


9 posted on 03/13/2025 4:22:12 PM PDT by ransomnote (IN GOD WE TRUST)
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To: Lazamataz

sadly true


10 posted on 03/13/2025 4:29:30 PM PDT by Gene Eric
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To: Varda

Totally true. I eat more fiber while on a low carb diet than most people that are not on any diet.


11 posted on 03/13/2025 4:42:23 PM PDT by Nicojones
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To: ConservativeMind
Here's the paper, pay-walled, alas:
NatureMicro: Dietary fibre counters the oncogenic potential of colibactin-producing Escherichia coli in colorectal cancer
https://www.nature.com/articles/s41564-025-01938-4

It's a mouse study. Is there any focus on fusobacterium nucleatum? (there is one cite) And what's in the high fat diet would need scrutiny, because with rare exception, lab rodent chows tend to be metabolic disasters.

Which GEM Project is this?

12 posted on 03/13/2025 4:44:06 PM PDT by Boundless (You don't need to wait for MAHA.)
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To: ConservativeMind

How can there be Keto bread?


13 posted on 03/13/2025 5:20:23 PM PDT by nickcarraway
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To: Varda

I am wondering about something...

Our ancestors - way back - ate mostly meat and fish, and didnt eat “fiber” - it wasn’t available year round.

Why haven’t the Inuit and other modern tribes all died off? They didn’t/dont consume fiber, nor do other groups, like the Masai in Africa. They arent all dienig from cancer the last time I checked?

I think this is “horse puckey research” with an agenda. But, I could be wrong, of course.


14 posted on 03/13/2025 5:29:22 PM PDT by jacquej (“You cannot have a conservative government with a liberal culture." (Mark Steyn))
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To: ConservativeMind

I am calling this BS. Maybe in 1 person in 10,000. Not for the rest of us for whom a low carb diet is extremely beneficial.


15 posted on 03/13/2025 5:32:03 PM PDT by Freedom_Is_Not_Free (America -- July 4, 1776 to November 3, 2020 -- R.I.P.)
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To: ConservativeMind

Tastes like rubber no thanks


16 posted on 03/13/2025 6:24:49 PM PDT by mel (There are only 2 races decent and undecent people )
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To: ConservativeMind

Thanks for posting. I am a huge fan of Sola bread. Tastes good and has lots of fiber. Does not spike blood glucose.


17 posted on 03/13/2025 8:13:32 PM PDT by Trumpisourlastchance
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To: ConservativeMind
I eat 3/4 Cup of oatmeal (8.2g of total dietary fiber) every morning. Poaching an egg in the later stages of cooking adds to the flavor with brown sugar a tab of butter and half & half--all in the pan used to cook the oatmeal.

Oats contain a specific type of soluble fiber called beta-glucan. Beta-glucan promotes healthy gut bacteria and intestinal health. Oatmeal is cheap! Adult men should aim for 38 grams of fiber every day.


18 posted on 03/14/2025 2:20:55 AM PDT by jonrick46 (Leftniks chase illusions of motherships at the end of the pier.)
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