Posted on 07/29/2024 12:12:55 PM PDT by Red Badger
A single injection of a new, off-the-shelf stem cell therapy for knee osteoarthritis significantly improved pain and function for up to 12 months in 75% of participants involved in a clinical trial. The treatment also has the potential to halt the disease’s progression.
In 2020, 7.6% of the global population had the painful degenerative condition osteoarthritis, an increase of 132.2% in total cases since 1990. It’s expected that by 2050, cases will have increased by 74.9% for knee, 48.6% for hand, and 78.6% for hip osteoarthritis.
Current treatment includes pain relief, usually with non-steroidal anti-inflammatory drugs (NSAIDs), exercise as tolerated, and joint replacement surgery. No available treatment delays the progression of the condition, and long-term use of NSAIDs increases the risk of stomach ulcers, kidney failure, and stroke or heart attack. However, clinical trials of a new one-injection stem cell treatment for osteoarthritis, developed by the private Australian biotech company Magellan Stem Cells, have shown very promising results.
“Our research indicates that Magellan’s off-the-shelf donor stem cell treatment is safe and effective in improving joint function, reducing pain levels, and may have the potential to halt the progression of osteoarthritis,” said Associate Professor Julien Freitag, lead researcher and Magellan’s Executive Director and Chief Medical Officer.
MAG200 is a single injection of donor stem cells into the joint (an intra-articular injection). It’s considered an ‘off-the-shelf’ therapy because it uses donor, or allogeneic, stem cells rather than the patient’s own, the surgical harvesting of which is labor-intensive. Importantly, because the treatment uses mesenchymal stem cells – adult stem cells that can differentiate into other cell types – from adipose tissue or body fat, it doesn’t trigger an immune response.
(Excerpt) Read more at newatlas.com ...
Thanks for asking.
Doing well now.
Was an injury to one knee 20 yrs ago and a lot of torn cartilage removed after.
Joint gradually wore down to bone on bone and replaced it with the Mako model.
Slow recovery and it scarred up before I could regain full bending flexing so had to have it manually broken free again.
Feels great and I don’t think about it much.
There’s app 150 articles posted here per day. I’ll let you read them all. You need the help 🤣
Would this work if the cartilage in in an area that’s avascular...?
Probably.................
I’ll be in that 20 percent in a few years.
I fell and hurt my hip about 14 years ago. Had a hip replacement 2 years ago on my 60th birthday. Now, my other hip has moderate arthritis and starting to be very painful.
The knees are bad too because of all the hip problems. I also have some weird congenital knee problems when my knee cap is small and floats around more than it should.
I find exercising is really helping the knees, but not doing much for my natural hip.
...For patients with knee OA, intra-articular injection of autologous ASCs or ADSVFs without adjuvant treatment showed remarkable clinical efficacy and safety at short-term follow-up. Some degree of efficacy has been shown for cartilage regeneration in knee OA, although the evidence remains limited. Further RCTs that directly compare ASCs and ADSVFs are needed.
Oh? Foreign cells aren't rejected?
In what universe?
Sometimes people with joint problems gain weight because they have so much pain that even mild exercise is impossible. You are very compassionate, aren’t you?
Don’t know if this applies to your situation, but I find that avoiding certain foods does wonders for my thumb arthritis.
Does "donor" mean aborted fetus?
“There’s app 150 articles posted here per day. I’ll let you read them all. You need the help”
You are counting? Looks like you posted to all. How many other stupid comments instead of doing your own homework?
"treatment uses mesenchymal stem cells – adult stem cells that can differentiate into other cell types – from adipose tissue or body fat, it doesn’t trigger an immune response."
A valid question.
See the link in post #7; the answer appears to be "no".
I was going to suggest you don’t quit your day job but it appears you don’t have one.
This will take many years to arrive for use, but this sounds cool.
I’m glad to hear that.
Thanks
Who has time to read articles with a Clown 🤡 like you stalking me ✌️
“Who has time to read articles with a Clown 🤡 like you stalking me ✌️”
Since when is replying to posts ‘stalking’?
Hush 🤡
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.