Posted on 02/06/2024 9:14:15 PM PST by ConservativeMind
Scientists have identified a less stringent and more manageable alternative to traditional intermittent fasting, offering new possibilities for extending lifespan and promoting healthy aging.
This novel method, involving short-term isoleucine deprivation, has shown remarkable results in fruit flies (Drosophila melanogaster).
The research found that intermittent, short-term omission of only the essential amino acid isoleucine from the diet significantly increases stress resistance and extends lifespan in fruit flies.
"Unlike conventional intermittent fasting, this approach does not require drastic reductions in overall food intake, making it a more practical and feasible strategy," said Tahila Fulton.
Previous research has shown that moderate restriction of all dietary amino acids can confer stress resistance.
The research team recently found that short-term deprivation of a single essential amino acid can enhance toxin resistance of young adult flies, but nothing was known about its efficacy in older flies, or how this diet might affect longer-term health.
To investigate this, the research team first assessed if flies could acquire nicotine tolerance from short bouts of isoleucine deprivation as they aged.
They maintained flies for one, two, three or five weeks (of their approximately nine-week mean lifespan) on a nutritionally complete synthetic diet, at which point they transferred them to a diet lacking isoleucine for one, three, five or seven days, and then measured their survival when exposed to a lethal toxin.
Using these data to select treatment regimes that offered optimal toxin protection, the authors found that subjecting flies to one week of isoleucine deprivation at mid (three weeks) and later (at five weeks) led to a remarkable increase in lifespan, irrespective of their diet in earlier and later stages of life.
The less severe approach of isoleucine deprivation mimics the benefits of broader dietary restrictions seen in conventional fasting methods.
(Excerpt) Read more at medicalxpress.com ...
Low isoleucine foods:
https://tools.myfooddata.com/nutrient-ranking-tool/isoleucine/all/lowest/household/common/no
“shown remarkable results in fruit flies “
That does it, works for me...................
/S
Nothing as easy for me as intermittent fasting. According to Johns Hopkins University,
“There are several different ways to do intermittent fasting, but they are all based on choosing regular time periods to eat and fast. For instance, you might try eating only during an eight-hour period each day and fast for the remainder. “
I do that quite naturally. Rarely hungry, I eat breakfast late, noon sometimes, and eat dinner about seven. . Never have lunch except about twice a month when I go out for lunch with friends. . And I weigh 116 with clothes on.
My secret? I hate to cook. Avoid fat and salt. Don’t eat wheat. Buy organic.
My dad was in the restaurant business and advised: “Buy the best food you can afford and do as little as possible to it.” I don’t have “recipes”. Steam potatoes and veggies, and have chicken,, or salmon, or tofu sautéed with mushrooms for dinner.. Beef maybe once every two weeks. That’s dinner. Nonfat yogurt with fruit for dessert.
At 87, I’m really healthy except osteoporosis has set in. Broke one knee last year, other ankle this year, so exercise isn’t happening. Worrisome.
Hmm...
Only from my cold, dead isoleucine receptors!
Regards,
Weight Loss scheme - bump for later...
I’m not eating fruit flies … /s
Scientists have identified a less stringent and more manageable alternative to traditional intermittent - intermittent dying.
.
So what are the high isoleucine foods that you should avoid for this diet to work? And is this an on off thing— or something you do forever?
You don’t eat all of them just those low in isoleucine. I wonder how hard it is tell them apart?
They fed fruit flies ‘nutritionally complete synthetic foods.’ Are they testing that amino acid or how well humans age on synthetic food?
Besides despising tofu and yogurt, your diet sounds good.
This doesn't sound simpler. The simplest way I know to avoid consuming isoleucine is (wait for it)...fasting.
Researchers find simpler alternative to intermittent fasting?
Intermittent eating?.................
Foods high in isoleucine include beef, chicken, pork, fish, tofu, dairy, beans, lentils, whole grains, nuts, seeds, and vegetables like peas.......................
Intermittent fasting requires avoiding all food.
When you are supposed to be fasting, you can now have an apple.
To me, fasting is taking in 2200 calories instead of 2800...
When I was younger it was about 500 more calories but at 71 I can’t burn as many as I used to...
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