People DON'T have to die of Xylazine

45 years in practice | 13 April 2023 | LTC.ret

[LTC.Ret]

I keep hearing about the fentanyl crisis, and now fentanyl being laced with xylazine. But today, I actually heard on the radio that there is nothing they can do about xylazine, which is why it is so deadly. The sad thing is that that information is 100% INCORRECT. Xylazine has TWO very effective reversal agents that Veterinarians use in practice frequently and effectively. A mixed product containing Narcan and yohimbine-or-tolazine would reverse BOTH elements in a fentanyl/xyalzine overdose.

I spoke to local authorities, and they were not familiar at all with yohimbine/tolazine for the reversal of xyalzine. I am now on a quest to spread the word and save lives if at all possible --- especially teenagers who unwittingly take drugs laced with either or both.

[LTC.Ret]

I am not sure who to contact, and I don't know if I can get to the ears in the right places. ANY and ALL help will be greatly appreciated. Let's save some LIVES!!!

[gnarledmaw]

Deputize people to assist you by providing reliable documentation.

[LTC.Ret]

https://pubmed.ncbi.nlm.nih.gov/11513261/

The drugs reversed the xylazine-induced decrease in the heart rate, respiratory rate and rate of ruminal movements, and also rapidly restored the reflexes as well as the reaction to noxious stimulation. In addition, they significantly (P < 0.05) decreased the mean standing time. The mean total recovery time was decreased significantly (P < 0.05) by 4-aminopyridine and the yohimbine/4-aminopyridine combination, but non-significantly (P > 0.05) by yohimbine. No relapse in sedation occurred. Overall, the combination of yohimbine and 4-aminopyridine produced better responses than the individual drugs, and may therefore be used for rapid reversal of xylazine-induced sedation in goats.

[LTC.Ret]

https://www.cbsnews.com/news/xylazine-doesnt-respond-to-naloxone-narcan-why-experts-explain/

Could scientists develop a reversal drug for xylazine?

There are currently no naloxone-like reversal agents for xylazine. On April 12, Dr. Rahul Gupta, the director of Office of National Drug Control Policy, said that he is requesting $11 million to develop a strategy to tackle the drug’s spread. Plans to do so include developing an antidote.

[Pocketdoor]

I think Chiefs of Police and Sheriffs would be a good start. Do you know any LEOs? I’ve seen video of cops going down and being revived by narcan. To say “Sorry” this new drug will kill an officer accidently exposed is crazy. I think LEO’s would have a very vested interest in running it up the chain of command.
GL!

[LTC.Ret]

https://nexgenvetrx.com/blog/nondomesticsexotics/reversals/tolazoline-reversal-dosages-for-wildlife/

Tolazoline as a Reversal Agent for Wildlife

Tolazoline (Tolazine® in the branded form) is an alpha-adrenergic antagonist that is used primarily as a reversal agent for xylazine. Tolazoline is FDA-approved and indicated for the reversal of effects associated with xylazine in horses. . . Thus, it is often used to reverse sedation and cardiovascular effects of xylazine in ruminants. It has also been used for reversing alpha-agonists in a variety of other species, but less safety and efficacy data is available.

[LTC.Ret]

It is impossible to find phone numbers to contact Dr. Rahul Gupta, the Trump Campaign, or basically anyone else anymore. We DO NOT need to spend millions of dollars to find a reversal agent for xylazine when TWO already exist with years of proof of efficacy.

If people die because no one is interested, we are all to blame.

Plus, if Trump wants to come forward with the answer without spending millions of dollars more to recreate what already exists -— so much better for him. He can be the one to save the kids dying of xyalzine. That’s OK by me.

Ignorance kills -— especially when the answer is already out there just waiting to be “discovered” by someone with the power to contact all the people with unpublished phone numbers!!!

[drSteve78]

This information is correct and current.

[TChad]

From here:

https://www.fda.gov/drugs/drug-safety-and-availability/fda-alerts-health-care-professionals-risks-patients-exposed-xylazine-illicit-drugs

"Since we do not know if reversal agents regularly used in veterinary medicine (e.g., yohimbine hydrochloride, tolazoline hydrochloride) are safe or effective in humans, they should not be used."

Sounds like it might help to use some of that big pharma money to promote human testing.

[gnarledmaw]

So much for “Right to Try”. We knew they would effit up.

[TChad]

So much for “Right to Try”.

I think for "Right to Try" to kick in, a drug must at least have passed an early phase of a (human) clinical trial. Also, only certain states have "Right to Try."

I guarantee that someone who works for the drug manufacturer knows exactly why the drug has not been approved for this use.

[Badboo]

To words: Big Pharma. And one more: Profit.

Same thing happened to ivermectin, but no-one can “explain” the absence of covid in the tropics.

They’ll get back to you once the patent spoils are split up.

[LTC.Ret]

https://www.mayoclinic.org/drugs-supplements/yohimbine-oral-route/side-effects/drg-20066766

Possible side effects WITH yohimbine: Fast heartbeat, increased blood pressure, dizziness, headache, irritability, nervousness, nausea and vomiting, skin flushing, sweating, tremor

Possible “side effects” WITHOUT yohimbine: Death

Hard choice, but I know which way I would go . . .

[LTC.Ret]

https://www.drugs.com/vet/tolazine-injection.html

Temporary side effects of Tolazine may be mild increases in blood pressure; tachycardia; peripheral vasodilatation, and sweating. Muscle fasciculations may be observed. All clinical side effects should dissipate within 60-120 minutes.

Permanent “side effects” without Tolazine: Death.

[Drago]

Not known to work in humans I guess:

“Xylazine is not currently known to be reversed by naloxone.
Because xylazine is not an opioid, associated toxicities may not be reversed by naloxone. Healthcare professionals who manage opioid overdoses should consider xylazine exposure if patients are not responding as expected when naloxone is administered or when signs or symptoms of xylazine exposure (e.g., unusual skin necrosis) are present. Other reversal agents regularly used in veterinary medicine (e.g., yohimbine hydrochloride, tolazoline hydrochloride) are not known to be safe and effective treatment options for xylazine-involved overdose in humans and should not be used. Appropriate supportive measures should be provided to patients who do not respond to naloxone.”

https://www.fda.gov/media/162981/download

and

https://www.drugs.com/illicit/xylazine.html

https://pubmed.ncbi.nlm.nih.gov/2859820/

https://pubmed.ncbi.nlm.nih.gov/2862816/

[TChad]

Permanent “side effects” without Tolazine: Death.

You've convinced me, now you just need to convince someone who can make money by fixing the problem.

[gnarledmaw]

“... a drug must at least have passed an early phase of a (human) clinical trial...”

I know, thats kind of the point. If 100% of people that have been exposed to a certain dose have died then you cant kill me twice as dead. There is really no downside to letting people try.

Probably. My guess is that the answer is too cheap and not patentable.

[dmcnash]

I lost my National Lampoon Drug Interaction chart but the combination fentanyl+nalaxone+xylazine+yohimbine/4-aminopyridine I am quite sure would lead too
"You are caught in a molecular tornado, then you die."

[LTC.Ret]

“You are caught in a molecular tornado, then you die.”

I sincerely doubt that. However, being caught between “you are overdosed and going to die without immediate intervention” and “there might be an unexpected drug interaction and maybe you might die” -— I believe I would opt for the latter.