Posted on 12/19/2022 3:50:39 PM PST by ConservativeMind
Researchers have demonstrated for the first time that high doses of cholesterol-lowering statins impair bone quality in mice. The finding came as no surprise for the scientists, who observed the correlation in a big data analysis of the Austrian population in 2019.
A 3D detailed imaging technique was used to examine the bone quality of the mice and found that long-term high dose statin therapy had detrimental effects on bone in both males and ovariectomized female mice. Different parts and characteristics of bone, such as volume and thickness, were affected. In male mice, bone volume of the trabecular femur (the spongy and porous bone) was reduced by 42 percent, while in female mice, it was reduced by 34 percent.
In the big data analysis, Klimek and his colleagues found that people taking high dose statins were four to six times more likely to develop osteoporosis. "The results are consistent with mouse data and our previous 2019 analysis," says Klimek.
"As a result of medical examinations, it should be evaluated if a specific therapy for osteoporosis should be initiated additionally to high-dose statin therapy earlier, especially in high-risk populations for osteoporosis. Calcium and Vitamin D levels should also be monitored regularly in patients under high-dose statin therapy," adds Leutner.
"However, it remains to be demonstrated whether newer cholesterol-reducing drugs, other than statins (like PCSK-9 inhibitors—newer and most effective drugs for the therapy of high cholesterol levels with proven cardiovascular benefits), have better effects on bone metabolism in humans. If so, the treatment should be tailored to the individual, especially for high-risk populations for osteoporosis, like postmenopausal women," they suggest.
"According to our results, doctors should also monitor bone metabolism in patients under high-doses of statins, as well as possibly begin with an additional bone protecting therapy in individual cases if necessary."
(Excerpt) Read more at medicalxpress.com ...
Personally, I’d find another way to mitigate cholesterol, and there are multiple other approaches one could take that would not have negatives.
“Personally, I’d find another way to mitigate cholesterol, and there are multiple other approaches one could take that would not have negatives.”
I could care less about cholesterol. Triglycerides are the key number (that’s what causes heart attacks), and pretty much any cholesterol level is fine, providing that you’re healthy and do a reasonable job of limiting carb intake (as in no bread, noodles, rice, or sugar).
“...as in no bread, noodles, rice, or sugar...”
THAT ain’t livin’....
That’s the way you do it on the MTV.
“THAT ain’t livin’....”
LOL, but not too hard to get used to, and of course you can cheat a bit. But keeping the macro-doses of carbs under control usually does the trick.
I will never take statins.
Damn… I’m gonna have to wean my mice off of statins. ;-)
I’d worry more if mice were humans.
My buddy said he’s legs ached...he discontinued the statins.
Triglycerides are the key number (that’s what causes heart attacks), and pretty much any cholesterol level is fine, providing that you’re healthy and do a reasonable job of limiting carb intake (as in no bread, noodles, rice, or sugar).
I must be the exception to the rule. Never any simple carbs, triglycerides always around 100, and just had my 2nd heart attack in 8 yrs. Last one (2015), the Stent put in is 100% blocked now. I have this 2nd Stent that I must now worry will block too. I think if that happens, it’s all over. There ain’t much more I can do to prevent my atherosclerosis.
Prayers
The war on cholesterol is pseudo-science on a par with the war on CO2. Among the elderly, the higher your cholesterol the longer you live.
“Without considering different statin dosages, we can state that males with statin therapy had a lower rate of diagnosed osteoporosis compared to controls (OR: 0.91, CI: 0.86–0.97, p < 0.01).”
Isn’t that good (favorable effect)? LOL
So don’t take high doses.
VA doc gonna be sad when I tell her NO to the statins.
Roseann Roseannedonna was correct. It’s always something.
Damn, sorry to hear. Best of luck.
Are you getting enough vitamin k in its several forms?
Looks like a lot of FReepers (statin bad! statin bad!) don’t understand the study excerpt in #15.
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