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Down on Vitamin D? It could be the cause of chronic inflammation
Medical Xpress / International Journal of Epidemiology ^ | August 8, 2022 | Ang Zhou et al

Posted on 08/09/2022 6:06:56 PM PDT by ConservativeMind

Inflammation is an essential part of the body's healing process. But when it persists, it can contribute to a wide range of complex diseases including type 2 diabetes, heart disease, and autoimmune diseases.

Now, research shows a direct link between low levels of vitamin D and high levels of inflammation, providing an important biomarker to identify people at higher risk of or severity of chronic illnesses with an inflammatory component.

The study examined the genetic data of participants in the UK Biobank, using Mendelian randomization to show the association between vitamin D and C-reactive protein levels, an indicator of inflammation.

UniSA's Dr. Ang Zhou says: "High levels of C-reactive protein are generated by the liver in response to inflammation, so when your body is experiencing chronic inflammation, it also shows higher levels of C-reactive protein.

"This study examined vitamin D and C-reactive proteins and found a one-way relationship between low levels of vitamin D and high levels of C-reactive protein, expressed as inflammation.

"Boosting vitamin D in people with deficiencies may reduce chronic inflammation, helping them avoid a number of related diseases."

The study also raises the possibility that having adequate vitamin D concentrations may mitigate complications arising from obesity and reduce the risk or severity of chronic illnesses with an inflammatory component, such as CVDs, diabetes, and autoimmune diseases.

Professor Elina Hyppönen, says these results are important and provide an explanation for some of the controversies in reported associations with vitamin D.

"We have repeatedly seen evidence for health benefits for increasing vitamin D concentrations in individuals with very low levels, while for others, there appears to be little to no benefit." Prof Hyppönen says.

"These findings highlight the importance of avoiding clinical vitamin D deficiency, and provide further evidence for the wide-ranging effects of hormonal vitamin D."

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: inflammation; vitamins; vitd
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To: ConservativeMind
Some interesting reading re:Vitamin D

https://www.biorxiv.org/content/10.1101/2022.06.29.498158v1

Note taking V K2 about 100 mcg per 5000 U of Vit D helps force the calcium into the skeletal structure where it belongs rather than the circulatory system.

21 posted on 08/09/2022 10:32:31 PM PDT by Polynikes (Nicht geimpft Mensch 2nd Klasse)
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To: djf

I take 10,000 units/day as part of my prophylaxis against the China Virus.

If and when the China Virus goes away, I’ll cut back to 5,000 units/day which is where I was before the China Virus caused me to adopt a prophylaxis against it. Successful so far.


22 posted on 08/09/2022 10:33:30 PM PDT by upchuck (The longer I remain unjabbed with the clot-shot, the more evidence I see supporting my decision.)
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To: ConservativeMind; rrrod; Neverlift; RummyChick; lizma2; Delta 21; arthurus; djf; upchuck; ...

Below is the most valuable study on Covid, and also Vitamin D, I have read in a long time. It has 3 very important findings which I will detail.

Vhttps://www.cureus.com/articles/76496-therapies-to-prevent-progression-of-covid-19-including-hydroxychloroquine-azithromycin-zinc-and-vitamin-d3-with-or-without-intravenous-vitamin-c-an-international-multicenter-randomized-trial

NOTE: This study and the one posted both use the measure nmol/L (nanomols per liter). That measure is used by many foreign countries. In the US we use ngm/mL (nanograms per milliliter). Divide nmol/L figures by 2.5 to get equivalent US ngm/mL figures. Thus 25 nmol/L equals 10 ngm/mL. Translated to ngm/mL, the above study says 30 or higher is OPTIMUM, 20 to 29 is insufficient, 10 to 19 is deficient, and below 10 is severely deficient. In the US, health organization Kaiser Permanente (KP) considers 50 to 80 OPTIMUM and above 80 moving into danger territory. Recently scientist have realized that the D level for good immunity seems to be higher than what is needed for bone health.

FINDING 1) After the study of almost 240 people was ended, original blood tests were evaluated. They found NOT ONE person had their OPTIMUM level, 3 were insufficient, and the rest divided between deficient and severely deficient. The one person who died had a reading of 3 ngm/mL. My take is: GET TO OPTIMUM D LEVEL AND YOU WILL LIKLY STAY OUT OF HOSPITALS.

FINDING 2) The original Zelenko Protocol of Zinc, HCQ, Azithromycin, plus added D3 and C is very effective even for hospitalized patients, although Dr. Zelenko recommended treating as early as possible in cases with possible Covid symptoms. Dr. Zelenko has since recommended using Zinc, Ivermectin and Doxycycline as being slightly safer medication, and using Quercetin if HCQ or Ivermectin are not available from a doctor.

FINDING 3) High dose IV (intravenous) Vitamin C substantially shortens days hospitalized (thus saving much medical expense). Compare this with Dr. Fauci’s beloved Remdesivir which had very little effect and cost the taxpayers $3000 per “free” treatment course.

To be safe, getting enough or not too much Vitamin D3, get a blood test and discuss dose with your doctor. In summer 2020 when I had realized lack of Vitamin D was probably a factor in clotting issues and vaccines, I had to decide how much to take on my own. My son and I live in the mid-Atlantic area. He is 6’1” and weighs 250 lb. and his doctor had recently increased him from 5000IU a day to 10,000IU for his SAD (winter depression). I am 5’3” and 145 lb. Summer 2020 I was spending about 5 days a month outdoors lawn mowing. I started taking 2000IU D, and as we went in to Autumn gradually increased to 5000IU for the 4 Winter months. I then reduced back to 2000 IU for summer 2021. In Dec. 2021 I had my annual physical, I was given my first Vitamin D blood test, and my KP OPTIMUM reading was 66 ngm/mL.

I strongly recommend you get the Vitamin D blood test, bring your reading to the OPTIMUM level, and stay out of hospitals if possible. Important NOTE, get your annual physical! My partner missed a year avoiding public exposure to Covid at KP. He now has prostate cancer which should have been diagnosed a year ago with better treatment options.


23 posted on 08/10/2022 5:09:19 AM PDT by gleeaikin (Question authority)
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To: djf

Sounds like way too much; recommended is 400-800 units per day. Vitamin K2+D3 (one pill) is better.


24 posted on 08/10/2022 5:45:58 AM PDT by SkyDancer ( I make airplanes fly, what's your super power?)
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To: SkyDancer

It seems that many(most?) people talk about “how much” vitamin D they take. This is nonsense.

The important issue is not how much we take, but how much we have in our blood. Unless you have your blood checked for vitamin D you have absolutely NO IDEA whether you are deficient or not.

And, another thing—the optimal blood level for vitamin D is actually quite a bit higher than the “recommended” level. Don’t be afraid of vitamin D supplements. Do some research and you will learn that overdosing on this vitamin is almost impossible, and has seldom ever been reported—even with enormous supplement intake.

Take this for what it is worth, but you need to know that an optimal vitamin level is absolutely necessary if you want to be healthy.

(The writer is 80 years old, seldom, if never sick, and has been taking thousands of IU of vitamin D3 for many years.)


25 posted on 08/10/2022 6:57:47 AM PDT by systemjim (Lifetime Lover of Music)
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To: gleeaikin

Thank you for the info.


26 posted on 08/10/2022 7:13:22 AM PDT by upchuck (The longer I remain unjabbed with the clot-shot, the more evidence I see supporting my decision.)
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To: systemjim; SkyDancer; ConservativeMind; All

About 13rd the US and world population is deficient in Vitamin D. Even people living in the tropics frequently are as it is harder for dark skin to allow the sun engendered D to absorb from the skin into the body. This is why the death rate of dark-skinned people including American Indians has been 2.5 times the rate for light-skinned people in this country. When calculating how much Vitamin D a person may need, you have to include time of year, location like north or south, and length of sun exposure. People in Florida and other southern location frequently stay inside for the air conditioning in Summer which probably explains aome increases in Covid in some southern states in Summer.

I guess by “writer” you mean me. Actually I am 84, and until Summer 2020 I was only taking the amount of Vitamin D in my twice daily one-a-day multi vitamin and mineral tablets, about 800IU daily. My health had been generally good because have been taking a targeted array of supplements for over 50 years. Then as explained in my Comment here I increased my D intake based on new Covid information and my on-line research. A lot of the newest research now recognizes the level of Vitamin D needed for a healthy immune system is much higher than what is needed for bone health and rickets. I have asked others living in the mid-Atlantic zone about their D intake. A 200 lb 5’11” man said his doctor gives him a 40,000IU D shot once a week. A tall chunky, not fat, black woman said her doctor put her on 10,000IU a decade ago. Two frail elderly black women told me their doctor recommended 5000IU daily. Using the information here and in my Comment, you can make a rough estimate of what to take, but get in to have your blood tested to fine tune your intake. If you have been using a lot for a while you might need to cut back a bit. Good luck, but do test.


27 posted on 08/10/2022 8:09:41 AM PDT by gleeaikin (Question authority)
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To: rrrod
my Vit D level was normal high....I have been taking 6000iu once a day during winter and 4000 during the summer....

I have diabetes and arthritis and its all still there....

but no covid, and not really been sick for a couple of years.

nobody in my household of three adults has been sick and we are not vaxxed....we all take our Vit d.

28 posted on 08/10/2022 8:17:34 AM PDT by cherry
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To: FreedomPoster

Don’t recall ...but I was taking multiple and a 600 calcium.


29 posted on 08/10/2022 8:21:58 AM PDT by rrrod (6)
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To: cherry

No probs here. I went thru a stage where the docs were changing my meds constantly..various problems but finally I’m on the mend and not taking as much meds.


30 posted on 08/10/2022 9:57:55 AM PDT by rrrod (6)
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To: RummyChick

I was just thinking this today. Those with osteoarthritis don’t budge a marker on the inflammation panels but one look at the inflamed and painful joints makes. E believe that the medical establishment has not isolated markers for another Inflammatory pathway.


31 posted on 08/10/2022 10:24:06 AM PDT by Chickensoup ( Leftists totalitarian fascists are eradicating conservatives. Leftists are genocidal. )
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To: Chickensoup

I have a test that can be used. It’s not commonly ordered. Drs don’t know what to do with it.

It’s normally ordered during research projects or by Oncologists.

It’s not expensive. You can get it done for $95 at Direct Labs.

LDH Isoenzyme Panel. The composition can tell you the bands where tissue damage is taking place.

Because of the bizarre way mine comes out I have been thinking about doing a CK isoenzyme panel for $72 at direct labs.

Will probably do that soon

This LDH test has been the proof I have showed to Drs to stop this nonsense of thinking things are just all in my head


32 posted on 08/10/2022 10:44:47 AM PDT by RummyChick
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To: RummyChick

Good to know


33 posted on 08/10/2022 11:03:10 AM PDT by Chickensoup ( Leftists totalitarian fascists are eradicating conservatives. Leftists are genocidal. )
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To: SkyDancer

I also argue that there is a vitamin d mania on Free Republic. People take too much and want a blood level higher than is possible with sun exposure. I made many posts about it, some this month.


34 posted on 08/10/2022 8:22:58 PM PDT by TTFX
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