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Study reverses long-held ideas about relationship among diabetes, fat and cardiovascular disease (Vascular issue causes diabetes)
Medical Xpress / Joslin Diabetes Center / Circulation Research ^ | August 5, 2022 | Jacqueline Mitchell / Kyoungmin Park et al

Posted on 08/06/2022 9:47:06 PM PDT by ConservativeMind

A major risk factor for diabetes, insulin resistance occurs when the cells of the body do not respond to insulin and cannot make use of the glucose (sugar) in the blood stream. The condition is known to increase the risk of cardiovascular disease and atherosclerosis.

George King, MD, identified a pathway in which the cells lining the blood vessels—called endothelial cells—drive the body's metabolism. In a reversal of scientific dogma, the findings suggest that vascular dysfunction may itself be the cause of undesirable metabolic changes that can lead to diabetes, not an effect as previously thought.

In addition to being linked to blood vessel abnormalities, diabetes is also associated with an undesirable decrease in the body's store of brown fat, also called brown adipose tissue. Unlike white fat which primarily stores energy, brown fat burns energy, maintains body temperature and regulates body weight and metabolism.

The team's investigation revealed that insulin signals endothelial cells in the blood vessels to produce nitrous oxide, which in turn triggers the production of brown fat cells. In the context of insulin resistance, endothelial cells produced less nitrous oxide—a decrease known to raise cardiovascular risk—leading to a drop in brown fat production. Because brown fat plays such an integral role in regulating the body's weight and metabolism, smaller brown fat stores could be a risk factor for, not a symptom of, diabetes.

Said King: "We think blood vessels and endothelial cells play an important role not just in regulating brown fat, but also in regulating whole body's metabolism. These endothelial cells are a key factor in regulating weight and developing diabetes and, as other labs have shown, blood vessels appear to be a major regulator of brain function as well. Intervening at the level of endothelial cells could have a major impact on many diseases."

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: antioxidants; atherosclerosis; cardiovascular; diabetes; insulin; insulinresistance; omega3fats; omega6fats
If you have Type 2 diabetes, you could do very well to get your vascular system under control. The endothelial layer lines all our blood vessels.

This is where antioxidants, Omega-3 fats, lowering Omega-6 fats, eliminating all simple sugars and all but the most complex carbs, can help. Strangely, this can put diabetes into remission, too.

There are supplements shown to rebuild this layer, too.

1 posted on 08/06/2022 9:47:06 PM PDT by ConservativeMind
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To: ConservativeMind
Arterosil is one proven approach:

https://biote.arterosil.com/

It actually is an approach to regress soft plaques arteries and vessels, as well as rebuild your endothelial lining.

You could also take supplements mentioned here:

https://kahn642.medium.com/reversal-of-clogged-arteries-is-real-here-are-some-ways-i-do-it-433b890bf77e

2 posted on 08/06/2022 9:56:26 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: Pete from Shawnee Mission; Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20% fewer pings) or “Everything” list.

3 posted on 08/06/2022 9:57:32 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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>> scientific dogma

love that...


4 posted on 08/06/2022 10:22:10 PM PDT by Gene Eric (Don't be a statist!)
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To: ConservativeMind

Ping


5 posted on 08/06/2022 10:25:49 PM PDT by dragonblustar (Romans 12:12)
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To: ConservativeMind
well I'm type two on oral meds and last A1c was high 8.9 but trending down...not checking my bs....

I need knee replacement and I need to get my A1c at 7 or below and get my weight down....

I've given up candy in the last 3 months and now for about 3 weeks I've had no bread/potato/pasta/rice/fruit juice, etc...iows...a keto like diet but I'm loathe to say I'm dieting....

can't say the weight has melted off but I do feel a little less heavy...lol....

I've always thought there is more to obesity and diabetes then just blaming the person...

my husband is a bit heavy and paunchy and he eats desserts all the time...no diabetes...my SIL is quite a large person and heavy...eats a lot of carbs....no diabetes at all.....

6 posted on 08/06/2022 10:39:55 PM PDT by cherry (;)
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To: ConservativeMind

CrazyBulk Nitric-Max


7 posted on 08/07/2022 12:28:59 AM PDT by jonrick46 (Leftnicks chase illusions of motherships at the end of the pier.)
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To: cherry

“can’t say the weight has melted off but I do feel a little less heavy”

In January, I started to do what you’re doing re sugar, pasta, potatoes, etc. Also no more diet pop or bananas. In June my tests showed a drop in glucose, and I had lost 15 pounds

I knew I felt lighter and my clothes fit better, but I haven’t stepped on a bathroom scale since the ‘90s.


8 posted on 08/07/2022 3:45:19 AM PDT by MayflowerMadam (Sometimes when you get to where you're supposed to be, it's too soon.)
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To: ConservativeMind

Bookmark.


9 posted on 08/07/2022 5:47:04 AM PDT by grobdriver (The CDC can KMA!)
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To: cherry

Being overweight and or having diabetes is a risk factor for cancer. My wife was 5’2” and 200lbs when diagnosed with breast cancer. She had a lumpectomy but it returned. She died.

After she was diagnosed stage 4 four years ago I put us both on a very low carb diet but it was too late for her. After about four months I went zero carb on the carnivore diet. I’m down 50 lbs and have a BMI of 24, blood work is excellent.

I don’t count calories but avoid carbs, eating meat, fish and eggs, drinking water or black coffee. It’s a very simple way of eating. I usually eat twice a day. I scramble 5 eggs for one meal, then have about a pound of meat later. The rule of thumb is to get 30% of your calories from protein. Or try for one gram of protein per pound of your ideal body weight.


10 posted on 08/07/2022 7:19:05 AM PDT by JohnnyP (Thinking is hard work (I stole that from Rush).)
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To: ConservativeMind
"There are supplements shown to rebuild this layer, too."

One of the supplements is rutin, similar to quercetin.

11 posted on 08/07/2022 7:48:40 AM PDT by matthew fuller (Murrill McLean Award, for cowardice by a Policeman, shooting of 12 lb. Mini-Dachshund. Danville, VA)
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To: matthew fuller

Interesting. Last summer I was on the Quercetin and D protocol. I lost 15 lbs and my A1C went into the great range. I have not been back for a year but I did stop the Quercetin and 10 lbs came back.

The weight just began melting away last summer. It was going away so fast I thought I was sick or had some kind of cancer.

How similar are Rutin and Quercetin?

Not sure why I quit the Quercetin but I think I’ll start it again and see what happens.

Interesting.


12 posted on 08/07/2022 8:41:59 AM PDT by Sequoyah101 (Politicians are only marginally good at one thing, being politicians. Otherwise they are fools.)
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To: Sequoyah101

Chemically, rutin is a glycoside that comprises flavonolic aglycone quercetin, along with disaccharide rutinose. Please don’t ask me to expound on that, see Doctor Axe-

https://draxe.com/nutrition/rutin/


13 posted on 08/07/2022 9:40:14 AM PDT by matthew fuller (Murrill McLean Award, for cowardice by a Policeman, shooting of 12 lb. Mini-Dachshund. Danville, VA)
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To: ConservativeMind

HFCS has to play hell on your muscles. USA is the only country making food stuffs with this crap in it. Sugar is still cheaper world wide than corn so the world uses sugar. US rates of type 2 are killing us faster that monkeypox and vaccinations combined!


14 posted on 08/07/2022 7:13:49 PM PDT by Delta 21 (It started as a virus, and mutated into an IQ test.)
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To: cherry

I am a carnivore and eat like one, cept I like it cooked a little. All that processed carb stuff in boxes with poison flavor packets will kill you.


15 posted on 08/07/2022 7:18:03 PM PDT by Delta 21 (It started as a virus, and mutated into an IQ test.)
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To: JohnnyP

That’s what I am shooting for. Good job! I just need to replace my coffee with beef broth. I can’t take coffee without sugar so if 1 goes they are both gone.

Sorry, about your wife.


16 posted on 08/07/2022 7:23:01 PM PDT by Delta 21 (It started as a virus, and mutated into an IQ test.)
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