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A Potential Cure for AIDS: Defeating HIV With a Single Injection
https://scitechdaily.com ^ | JULY 5, 2022 | By TEL-AVIV UNIVERSITY

Posted on 07/05/2022 1:21:56 PM PDT by Red Badger

Disintegrating Virus Cell Destroy COVID Concept

The injection causes type B white blood cells to be genetically engineered inside the patient’s body that would generate neutralizing antibodies against the HIV virus.

The technology also has the potential to be developed into a cure for AIDS Adi Barzel

Lead author of the study, Dr. Adi Barzel. Credit: Tel Aviv University

A new study from Tel Aviv University proposes a novel AIDS treatment that could be turned into a vaccine or a one-time treatment for HIV patients. The research explored modifying type B white blood cells in the patient’s body to release anti-HIV antibodies in response to the virus. Dr. Adi Barzel and Ph.D. student Alessio Nehmad led the study, which was conducted in partnership with the Sourasky Medical Center (Ichilov), the George S. Wise department of life sciences, and the Dotan Center for Advanced Therapies. The study was carried out in cooperation with other researchers from Israel and the United States. The findings were published recently in the renowned journal Nature Biotechnology.

Many AIDS patients’ lives have improved during the past two decades as a result of the administration of medicines that have transformed the condition from fatal to chronic. However, we have a long way to go before finding a medication that can offer patients a permanent cure. Dr. Barzel’s laboratory pioneered one feasible method, a one-time injection. His team devised a technology that employs type B white blood cells that are genetically altered within the patient’s body to release neutralizing antibodies against the HIV virus, which causes the disease.

B cells are white blood cells that produce antibodies against viruses, bacteria, and other pathogens. Bone marrow is where B cells are formed. When they mature, B cells move into the blood and lymphatic system and from there to the different body parts.

Dr. Barzel explains: “Until now, only a few scientists, and we among them, had been able to engineer B cells outside of the body, and in this study, we were the first to do this in the body and to make these cells generate desired antibodies. The genetic engineering is done with viral carriers derived from viruses that were engineered so as not to cause damage but only to bring the gene coding for the antibody into the B cells in the body. Additionally, in this case, we have been able to accurately introduce the antibodies into a desired site in the B cell genome. All model animals who had been administered the treatment responded and had high quantities of the desired antibody in their blood. We produced the antibody from the blood and made sure it was actually effective in neutralizing the HIV virus in the lab dish.”

The genetic editing was done with CRISPR. This is a technology based on a bacterial immune system against viruses. The bacteria use the CRISPR systems as a sort of molecular “search engine” to locate viral sequences and cut them in order to disable them. Two biochemists who had figured out the sophisticated defense mechanism, Emmanuelle Charpentier and Jennifer Doudna, were able to reroute for the cleavage of any DNA of choice. The technology has since been used to either disable unwanted genes or repair and insert desired genes. Doudna and Charpentier earned international recognition when they became chemistry Nobel Prize winners in 2020.

Engineered HIV Cells

The picture shows staining for engineered cells that secrete the antibody against HIV. Credit: Tel Aviv University

Ph.D. student Alessio Nehmad elaborated on the use of CRISPR: “We incorporate the capability of a CRISPR to direct the introduction of genes into desired sites along with the capabilities of viral carriers to bring desired genes to desired cells. Thus, we are able to engineer the B cells inside the patient’s body. We use two viral carriers of the AAV family, one carrier codes for the desired antibody, and the second carrier codes the CRISPR system. When the CRISPR cuts in the desired site in the genome of the B cells it directs the introduction of the desired gene: the gene coding for the antibody against the HIV virus, which causes AIDS.”

Currently, the researchers explain, there is no genetic treatment for AIDS, so the research opportunities are vast. Dr. Barzel concludes: “We developed an innovative treatment that may defeat the virus with a one-time injection, with the potential of bringing about tremendous improvement in the patients’ condition. When the engineered B cells encounter the virus, the virus stimulates and encourages them to divide, so we are utilizing the very cause of the disease to combat it. Furthermore, if the virus changes, the B cells will also change accordingly in order to combat it, so we have created the first medication ever that can evolve in the body and defeat viruses in the ‘arms race’.”

He continues, “Based on this study we can expect that over the coming years we will be able to produce in this way a medication for AIDS, for additional infectious diseases and for certain types of cancer caused by a virus, such as cervical cancer, head, and neck cancer and more”.

Reference: “In vivo engineered B cells secrete high titers of broadly neutralizing anti-HIV antibodies in mice” by Alessio D. Nahmad, Cicera R. Lazzarotto, Natalie Zelikson, Talia Kustin, Mary Tenuta, Deli Huang, Inbal Reuveni, Daniel Nataf, Yuval Raviv, Miriam Horovitz-Fried, Iris Dotan, Yaron Carmi, Rina Rosin-Arbesfeld, David Nemazee, James E. Voss, Adi Stern, Shengdar Q. Tsai and Adi Barzel, 9 June 2022, Nature Biotechnology. DOI: 10.1038/s41587-022-01328-9


TOPICS: Business/Economy; Health/Medicine; History; Society
KEYWORDS: antibodies; bone; bonemarrow; qanon; whitebloodcells
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1 posted on 07/05/2022 1:21:56 PM PDT by Red Badger
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To: Red Badger

problem, reaction then solution


2 posted on 07/05/2022 1:27:12 PM PDT by Steve Van Doorn (*in my best Eric Cartman voice* 'I love you, guys')
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To: Red Badger

only complication is that everybody has to get one, from newborns to geriatrics for public health and justice concerns. (sarcasm)


3 posted on 07/05/2022 1:28:25 PM PDT by epluribus_2
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To: Red Badger

This will help many bloggers and Qtards.


4 posted on 07/05/2022 1:29:31 PM PDT by humblegunner (Ain't drownin', Just wavin'...)
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To: Red Badger
"However, we have a long way to go before finding a medication that can offer patients a permanent cure.

CLICK BAIT.

5 posted on 07/05/2022 1:29:51 PM PDT by Salvavida
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To: epluribus_2

How about just isolate those witth HIV and let things take their course?


6 posted on 07/05/2022 1:31:51 PM PDT by Rurudyne (Standup Philosopher)
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Are we done playing God yet?
7 posted on 07/05/2022 1:33:19 PM PDT by glaseatr (Father of a Marine, Uncle of SGT Adam Estep. A Co. 2/5 Cav. KIA Thurs April 29, 2004 Baghdad Iraq)
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To: Red Badger

Or, maybe stop with the risky behaviors..and Monkees?


8 posted on 07/05/2022 1:33:24 PM PDT by Leep (Hillary will NEVER be president! 😁)
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To: Red Badger

Only ONE injection? How the heck is Big Pharma and their minions gonna make any money off of THAT?

And what about the, ‘Ten Percent for The Big Guy?’ Don’t ever forget THAT part of the deal in any of this!

*Rolleyes*


9 posted on 07/05/2022 1:33:53 PM PDT by Diana in Wisconsin (I don't have, 'Hobbies.' I'm developing a robust Post-Apocalyptic skill set. )
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To: Red Badger
A cure for AIDS! Yay! The only potential side effect: a sudden quick death. Oh, and you can still get it.

Wait, that was COVID, not AIDS. Never mind.

10 posted on 07/05/2022 1:34:41 PM PDT by pepsi_junkie (Often wrong, but never in doubt!)
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To: Red Badger

Pfizer should have a vaccine any day now, and the best part is it doubles as a booster for Covid.

That’s the trouble with losing your credibility. It is a biatch to get it back.


11 posted on 07/05/2022 1:35:56 PM PDT by yefragetuwrabrumuy ("All he had was a handgun. Why did you think that was a threat?" --Rittenhouse Prosecutor)
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To: pepsi_junkie

A cure for AIDS! Yay! The only potential side effect: a sudden quick death. Oh, and you can still get it.
Wait, that was COVID, not AIDS. Never mind.
/\

SSDD

Didn’t this vaxsnakeoil start with promises of and aids vaccine by fauci ?

The original virus panic 1.0 ?

They’ve closed the business loop.
Eternal infinite vaccines.

Pretty soon , there will be vacxs for the vaccine ! Wait,,, oh ya,, been done,,, gates’ polio vaccine for people who got polio from the polio vaccine.....

All Hail Vaccines !!!!!!

$$$$$!

!!!!#

.


12 posted on 07/05/2022 1:40:35 PM PDT by cuz1961 (USCGR Veteran )
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To: Red Badger

I don’t think AIDS is curable. It is a syndrome not a pathogen, and it smacks people with different diseases and conditions who have severely compromised immune systems which is characteristic of homosexual men. Some medical sources are predicting AIDS to become a problem among the vaxxed because of compromised and deteriorating immune systems following upon the Vaxx.


13 posted on 07/05/2022 2:03:19 PM PDT by arthurus (o covfefe )
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“potential...”

“would generate...”

Not enough weasel words in this Science! article. Why do people still entertain this crap?


14 posted on 07/05/2022 2:20:36 PM PDT by proust (All posts made under this handle are, for the intents and purposes of the author, considered satire.)
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To: Rurudyne

That would be homophobic. /sarc


15 posted on 07/05/2022 2:38:02 PM PDT by EvilCapitalist (Sodomy is nothing to be proud of.)
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To: Diana in Wisconsin

Yup,that’s why this will go nowhere.🙄🤔


16 posted on 07/05/2022 2:53:52 PM PDT by BiteYourSelf ( Earth first we'll strip mine the other planets later.)
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To: arthurus
"I don’t think AIDS is curable. It(AIDS) is a syndrome not a pathogen"

It's curable and not that difficult either. First. Covid and the injections had three GP-120 genes on them (fragment of HIV-1)

FLCCC has three products under long covid that kills HIV-1.
maraviroc (prescription) and Nigella Sativa (over the counter), Iota-carrageenan a polyanionic inhibitor (fights HIV) and Alpha-zam(Black Seeds (Nigella Sativa))
GP-120 genes bonds to CD4 cells or T-Helper cells. This also means your body will not attack it.

Absolute proof: The Gp-120 sequences prove beyond all doubt that "COVID-19" was man-made
https://arkmedic.substack.com/p/absolute-proof-the-gp-120-sequences?s=r

What is also interesting rating the best products to fight Covid also kills HIV
https://c19early.com/
17 posted on 07/05/2022 3:05:55 PM PDT by Steve Van Doorn (*in my best Eric Cartman voice* 'I love you, guys')
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To: epluribus_2

AND IT TURNS YOU CHASTE FOREVER!

Still want it? Didn’t think so.


18 posted on 07/05/2022 3:20:15 PM PDT by If You Want It Fixed - Fix It ( )
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To: Red Badger
"genetically engineered inside the patient’s body"



Where have I heard that before?
19 posted on 07/05/2022 4:16:31 PM PDT by Bikkuri (I am proud to be a PureBlood.)
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To: Steve Van Doorn

AIDS is not HIV. AIDS is a collection of pathogens and cancers that are attendant on a badly compromised immune system, at least outside of sub-Saharan Africa. HIV and homosexual activity suppress the immune system and leave the body open to the weird diseases that have afflicted homosexual men forever. They got more common when HIV was added.


20 posted on 07/05/2022 5:28:56 PM PDT by arthurus (o covfefe j)
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