Posted on 06/04/2022 9:46:00 AM PDT by ConservativeMind
Researchers have invented a new analytical method that sheds light on an enduring mystery regarding type 2 diabetes: Why some obese patients develop the disease and others don't.
For some patients, their body does not properly respond to insulin—it resists the effects of insulin, the hormone produced by the pancreas that opens the door for sugar to enter cells. In the later disease stages, when the pancreas is exhausted, patients don't produce enough insulin to maintain normal glucose levels.
In either case, sugar builds up in the bloodstream and impairs many major organs, sometimes to disabling or life-threatening degrees. A key risk factor for type 2 diabetes is being overweight, often a result of eating too much fat and sugar in combination with low physical activity.
"Our experiments and analysis predict that a high-fat/high-sugar diet primarily acts in white adipose tissue by driving microbiota-related damage to the energy synthesis process, leading to systemic insulin resistance," said Morgun.
In the study, the scientists relied on transkingdom network analysis and multi-organ network analysis. They also conducted experiments in mice, looking at the intestine, liver, muscle and white adipose tissue, and examined the molecular signature—which genes were being expressed—of white adipose tissue macrophages in obese human patients.
"Diabetes induced by the western diet is characterized by microbiota-dependent mitochondrial damage," Morgun said. "Adipose tissue has a predominant role in systemic insulin resistance, and we characterized the gene expression program and the key master regulator of adipose tissue macrophage that are associated with insulin resistance. We discovered that the Oscillibacter microbe, enriched by a western diet, causes an increase of the insulin-resistant adipose tissue macrophage."
"We previously showed that Romboutsia ilealis worsens glucose tolerance by inhibiting insulin levels, which may be relevant to more advanced stages of type 2 diabetes," Shulzhenko said.
(Excerpt) Read more at medicalxpress.com ...
We should be able to blunt this effect on either a low fat, or low carb, diet.
The researchers are getting DANGEROUSLY CLOSE to what Jason Fung has been saying for about a decade.
...they best be careful.
Fung and Ekberg cracked this a while ago. Go find their videos on YouTube. There is no reason for T2 diabetes to happen or continue other than ignorance.
I have been saying this for decades..
You don’t have diabetes because you are fat...
You are fat because you have diabetes
You put too much stress on them and they fail.
Here is the hook, everyone's limits are different.
Technically, only one family causes the macrophage issue and blunts insulin response in fat.
The other causes a separate insulin issue that blunts the release of insulin.
I had no idea there was a thing called omentum but it can be chronically inflamed.
Not low fat.
Low refined carb/sugar. Preferably zero/near zero.
.
Jason Fong the low-tech solution to a nasty problems. Intermittent fasting and you actually save money. And gives your digestive system 10 hours off every day. Jason Fong for the Nobel prize in medicine. It’s a no-pancreaser.
Definitely go watch their videos and pay attention to them. But they didn't come up with this stuff. They are just two of what is now a fairly large number of popularizers of proper nutrition.
Both diabetes and obesity have a common cause that isn’t each other. That cause is triggered by diet. What you eat, not how much.
“...families to encourage macrophages to enter white fat cells...”
Why does it always have to be about race?
I’ve done intermittent fasting and haven’t lost a pound. It doesn’t work for everyone. I’m a night owl and I often eat dinner at 11 pm. Then I eat breakfast at around 2 pm. Maybe the time of day matters too, which is why it doesn’t work for me, but the proponents of intermittent fasting never address that issue. 😖
Imma call bs on this one.
I was 200 pounds of muscle, when I was diagnosed.
My A1C was just over 14.
My diet was excellent and exercise was good.
My doctor put me on medication.
Then he told me that I was going to gain weight. Alot.
I laughed at him, told him I eat well and exercised.
He chuckled.
Well, here it is, 2 years later, my A1C is 5.8 ( damn near normal ) and my weight is 255.
I’m working my ass off to try and lose some. It’s like running against the wind in a hurricanes.
I asked my doctor why the weight gain.
He said my body was rebooting itself, and the result is weight gain.
Why do you think diabetics that have lost weight make headlines?
Because it is virtually impossible.
The you are diabetic because you are fat crowd are ignorant of both this disease and it’s effects on those that suffer from it.
Bkmk
Bkmk
Did your doctor give you any guidance about your diet?
Many examples of type 2 diabetes in remission on youtube, eating the carnivore diet.
I’m one of them. I went from 235 to 180, sitting at 190 now. Four years carnivore, no meds, aic 5.5. My T is up, too. Was 521 last time they checked and I’m 75.
This has been a long process.
I am very slowly starting to lose weight, but it is a struggle. 2 pound loss, 1 pound gain, like that. But I am making headway.
What people don’t realize, is that as a diabetic, you have to watch what you eat anyway. They think the problem is high blood sugar.
High blood sugar will kill you slow, but LOW blood sugar will kill you NOW. So, diabetics HAVE to eat.
We have a hard road ahead of us in this battle. The last thing we need is people that have no idea what they are talking about calling us fat.
We know we are fat. We are fighting the battle every day.
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