Posted on 04/07/2022 8:37:38 PM PDT by ConservativeMind
A diet involving short-term, severe calorie restriction was safe, feasible, and resulted in a decrease of blood glucose and growth factor concentration, reduction in peripheral blood immunosuppressive cells, and enhanced intratumor T-cell infiltration in cancer patients receiving standard-of-care therapy, according to a trial.
Preclinical research has demonstrated that severe calorie restriction in the form of cyclic fasting or fasting-mimicking diet (FMD) has potent anticancer effects when combined with standard pharmacological treatments.
The researchers administered an FMD regimen to the study participants that consisted of a five-day, low-carbohydrate, low-protein, plant-derived diet, which provided up to 600 Kcal on day 1 and up to 300 Kcal on days 2, 3, 4, and 5, for a total amount of up to 1,800 Kcal in five days. The cycle was repeated every three or four weeks for up to a maximum of eight consecutive cycles. Calorie restriction was followed by a refeeding period of 16 to 23 days, during which patients were not subjected to specific dietary restrictions.
In 99 evaluable patients, the FMD regimen reduced the median plasma glucose concentration by 18.6 percent, serum insulin by 50.7 percent, and serum IGF-1 by 30.3 percent.
The researchers found a significant decrease of circulating immunosuppressive myeloid subpopulations and an increase of activated CD8+ T cells.
To investigate the effects of the FMD diet on intratumor immunity, Vernieri and colleagues performed an interim analysis of another ongoing trial (DigesT) testing a five-day FMD cycle seven to 10 days before surgery in early-stage breast cancer and melanoma patients. Specifically, they evaluated the tumor-infiltrating immune cells and transcriptomic immune profiles in 22 breast cancer patients for whom enough tumor tissue had been collected.
This analysis revealed a significant increase in tumor-infiltrating CD8+ T cells and other changes, indicating a functional switch toward an antitumor immune microenvironment following FMD.
(Excerpt) Read more at medicalxpress.com ...
Here are notes I made at the end of year one. I asked for a thorough checkup.
BTW I found fasting much easier than dieting.
Had my first checkup after a year fasting 5 days a week.
Weight down 150 pounds.
BP went from 180/90 to 118/80
A1C from 6.8 to 5.4
Triglycerides went from 365 to 136
LDL from 138 to 43
HDL unchanged. Still a little low. 33
Doctor said Type 2 Diabetes is in remission.
He said KEEP UP THE FASTING.
“after a year fasting 5 days a week.
Weight down 150 pounds.
BP went from 180/90 to 118/80
A1C from 6.8 to 5.4
Triglycerides went from 365 to 136
LDL from 138 to 43
HDL unchanged. Still a little low. 33
Doctor said Type 2 Diabetes is in remission.”
My hat is off to you. Well Done!
It is a spiritual triumph, as well as a physical one.
It reflects great credit on you.
I actually enjoy fasting.
It started for spiritual rseasons, but the weight loss and health benefits became just as much a motivation.
I started with 10 or 15 day fasts, but my wife was so worrried I’d come off a fast and she wouldn’t have fixed enough supper for me, too. So I settled on a weekly schedule to make it easier on her.
I wasn’t public about it until the VP over my company approached me. People were concerned I had cancer because I was losing weight rapidly.
I have to admit working from home has messed me up. I’m planning to get back into my routine ASAP.
“I actually enjoy fasting.”
What is it that you enjoy?
I enjoy the feeling of being less dependent on food.
I also took the money I spent on food and asked God to show me people who needed it. That led to some very interesting encounters.
And I found out I didn't really know what hunger is. What I thought was hunger was really either a need for some electrolytes or it was boredom.
Well you have inspired me to kick off a fast mimicking diet for Holy Week.
I will estimate my food savings, and donate it for Ukrainian refugee relief.
AWESOME.
I’m going to get back on the program, too.
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