Posted on 02/15/2022 9:20:56 AM PST by Red Badger
A new preclinical study has demonstrated how an experimental drug can treat type 2 diabetes by increasing the expression of a recently discovered protein found to influence insulin signaling in cells. Across several mouse studies, the research shows the novel compound improved aspects of metabolic syndrome associated with diabetes.
In the early 2000s, a protein dubbed SWELL1 was identified and it was initially thought to solely play a role in lymphocyte function. Around a decade later, researchers discovered SWELL1 also influences insulin signaling in many tissues across the body. Subsequent study revealed SWELL1 activity is vital for normal insulin secretion from pancreatic cells. And, SWELL1 activity seems to be significantly disrupted in type 2 diabetic patients.
“Since T2D [type 2 diabetes] is characterized by both a loss of insulin sensitivity of target tissues (fat, skeletal muscle, liver) and ultimately, impaired insulin secretion from the pancreatic β-cell, these data raised the question: could impaired SWELL1-mediated signaling contribute to T2D pathogenesis, and if so, could this be corrected pharmacologically to improve systemic glycemia?” the researchers wrote in the new study.
Rajan Sah, senior author on the study, says SWELL1 has a double life, affecting insulin sensitivity in a number of cells across the body, while at the same time influencing insulin secretion from the pancreas. So his team developed a molecule called SN-401 to augment SWELL1 expression in the hopes it could normalize metabolic function in diabetic animals.
“This protein, SWELL1, has a sort of dual personality,” explained Sah. “The compound binds to SWELL1 in a manner that stabilizes the protein complex so as to enhance expression and signaling across multiple tissues, including adipose, skeletal muscle, liver, the inner lining of blood vessels, and pancreatic islet cells. This restores both insulin sensitivity across tissue types and insulin secretion in the pancreas.”
(Excerpt) Read more at newatlas.com ...
Sending prayers for you, ch
Thank you kindly, so much.
Somehow, my eyes just got blurry.
I appreciate the FR threads that have little/few arguments. My time is shorter now. I’d rather watch Takis videos on dogs at his Cretan shelter.
That’s great it works for you. Doc took hubby off Metformin and told him to take Metamucil. No side effects, unless you have diarrhea/bowel problems. It says on the package that it helps A1C. Not many people are aware. Even people in the medical field that he has talked to didn’t know that, or they said they didn’t.
Hope it works for him the same as Metformin works for others, to add years to his life.
It took me a long time to get used to the 80mg of Atorvastatin, up from 29, but with 5 stents in my heart (”full metal jacket”), I had no choice, except a quad bypass, which I was too sick to undergo. My health went sideways in 2016, l and so much hospitalization and 15+ operations, it’s stable now.
I’m in God’s waiting room, but He hasn’t called me into His office, just yet.
God Bless You, c_b.
I think God wants us to witness the storm coming our way.
My dad’s the same way, two heart attacks, a bunch of stents, a pacemaker, and still waking up at 6 AM every day to cut wood.
Thank you kindly
I believe you’re right.
We’re all in God’s waiting room, but He hasn’t called us into His office, just yet.
It looks like anything that extends the telomeres increases life span. Test animals that have lived a life of restricted caloric intake have extended telomeres and live longer than normal lives.
Now, I've also read that children born from older parents have a shorter life because they're born with short telomeres.
Adults with short telomeres can extend the length of their telomeres by serious calorie intake restriction.
Yes!!!!
You win the internet today!!!
What most people don’t realize is:
You don’t have diabetes because you are fat...
You are fat because you have diabetes.
A whole lot of ignorance about diabetes out there.
Mark my words. Like HGH, this drug will be abused wholesale.
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