Posted on 01/02/2022 2:06:59 PM PST by ConservativeMind
A study has revealed new insights into how a diet rich in red meat increases risk for cardiovascular disease.
In previous studies, Dr. Hazen found that a byproduct that forms when gut bacteria digest certain nutrients abundant in red meat and other animal products—called TMAO (trimethylamine N-oxide)—increases the risk of heart disease and stroke.
In 2018, Dr. Hazen published results showing that dietary carnitine is converted into TMAO in the gut through a two-step, two microbe process. An intermediary metabolite in this process is a molecule called γBB (gamma-butyrobetaine).
According to Dr. Hazen, multiple gut microbes can convert dietary carnitine to γBB, but very few can transform the molecule to TMA, the precursor to TMAO. "In omnivores, Emergencia timonensis is the primary human gut microbe involved in the transformation of γBB to TMA/TMAO. Conversely, long-term vegetarians and vegans have very low levels of this microbe in their gut and therefore have minimal to no capacity to convert carnitine into TMAO."
The researchers studied the relationship between fasting plasma γBB levels and disease outcomes using samples and clinical data collected from nearly 3,000 patients. Higher γBB levels were associated with cardiovascular disease and major adverse events including death, non-fatal heart attack or stroke.
"By studying patient samples, we saw that the abundance of gbuA [a gene] is significantly associated with a diet rich in red meat and plasma TMAO levels," said Dr. Hazen. "Patients who transitioned to a non-meat diet went on to exhibit reduced gut microbial levels of gbuA. Taken together, this suggests that dietary modifications may help reduce diet- and TMAO- associated cardiovascular disease risk. Likewise, the role of the gbu gene cluster may be worth exploring as a potential therapeutic target."
(Excerpt) Read more at medicalxpress.com ...
always...with the moo barely out of it. ;)
Did they evaluate grass fed vs warehouse red meat?
Straight into my veins. I’ll pick out my casket while it cooks.
You can always eat GMO soybeans
You can always eat GMO soybeans
I have a resting pulse of about 51 beats per minute. Am I doing something wrong here?
I’ll stick to my carnivore diet. If I only make 85 instead of 87 it will have been well worth it.
Dr. Hazen doesn’t look so healthy himself...
I am a kind and gentle man. Stand between me and my plate of steak tartar and we have a problem, a violent problem. :)
Anybody but me wondering just who might have funded the study?
Thinking of Ancel Keyes at the moment, and how he cherry-picked his countries to push his pet theories about diet and heart disease...
The older you are, the harder you can sometimes be to fool.
Ancel Keyes was the original Fauci.
Balsamic vinegar or olive oil? So the problem isn’t a consumption of red meat, but a failure to marinate.
Red meat loves olive oil. Now, back to my grilled KC Strip steak.
All you can do is put it out there. If some are incurious about things that affect their health its on them!
I have red Meat 1 or 2 times a week. From now on I will make certain to have something with Olive oil at the same time. (There are a lot of good reasons to enjoy the Mediterranean diet! ;)
Best thread of the year award!
That’s easy to do- salad with olive oil and balsamic vinegar. I consume both anyway. This is so interesting- thanks!
Exactly. Processed foods that are killings millions of people are ignored.
Is good for you. Its not good for you. Its good for you. its not good for you.
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