Posted on 12/07/2021 10:50:18 AM PST by SeekAndFind
The Cleveland Clinic released a statement today announcing some unexpected but exciting news: Viagra may be an effective preventative for Alzheimer’s Disease (AD).
A new Cleveland Clinic-led study has identified sildenafil – an FDA-approved therapy for erectile dysfunction (Viagra) and pulmonary hypertension (Ravatio) – as a promising drug candidate to help prevent and treat Alzheimer’s disease
The research team, led by Feixiong Cheng, Ph.D., of Cleveland Clinic’s Genomic Medicine Institute, made the discovery as part of a data-mining study. They performed a large-scale computational analysis of medical insurance data from over 7 million patients, evaluating medicines already FDA-approved and in use as possible candidates for repurposing as therapeutics for the devastating disease.
Sildenafil came out on top, associated with a 69% (snicker) reduction in the incidence of AD in patients who took the drug.
The researchers then went on to create an AD-affected brain cell model on which they further tested sildenafil’s effect on the disease. The results here were promising as well:
In the model, they found that sildenafil increased brain cell growth and decreased hyperphosphorylation of tau proteins (a hallmark which leads to neurofibrillary tangles), offering biological insights into how sildenafil may influence disease-related brain changes.
As usual in the early stages of drug assessment, more research needs to be performed before sildenafil can definitively be declared an effective treatment for Alzheimer’s:
“Because our findings only establish an association between sildenafil use and reduced incidence of Alzheimer’s disease, we are now planning a mechanistic trial and a phase II randomized clinical trial to test causality and confirm sildenafil’s clinical benefits for Alzheimer’s patients,” said Dr. Cheng. “We also foresee our approach being applied to other neurodegenerative diseases, including Parkinson’s disease and amyotrophic lateral sclerosis, to accelerate the drug discovery process.”
(Excerpt) Read more at pjmedia.com ...
Ravatio— for right sided congestive heart failure treatment.
Not a treatment for “Alzheimers”... perhaps a treatment for vascular dementia. Key word: Vascular as in blood vessels which do not deliver oxygenated blood to certain areas of the brain... and kill the cells. Vascular dementia.
JoeBama has this... but please don’t give him any of this- he won’t keep his hands off the little girls.
Ok, so some old stricken dude starts screaming about this appendage that grew on him! Yeesh!
The infamous expression is that God gave man only enough blood flow to operate one head at a time.
I think that would be called a double header.☺
Hey Babe, want to help my Alzheimer’s?
Question for Medicare.
Would Free Viagra be cheaper than Alzheimer’s care ?
Who needs memories as long as you’ve got something to play with.
No surprise if you believe the old saying that mens’ brains are between their legs ...
Always knew where the real brain was..lol..lol
I’ll look forward to the day that I’ll not only get a woody but remember what it’s for.
All the blood going to a males brain helps.
Well Bob Dole didn’t die of Alzheimer’s so there’s your proof!
I’m hard on it.
It’s a hard one to forget.
Wooden you like to see the hard data before drawing any conclusions?
Interesting and different.
That was pretty good.
5.56mm
Thanks!!!
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