Posted on 08/17/2021 8:20:59 AM PDT by Red Badger
New evidence shows that patients with Long COVID syndrome continue to have higher measures of blood clotting, which may help explain their persistent symptoms, such as reduced physical fitness and fatigue.
The study, led by researchers from RCSI University of Medicine and Health Sciences, is published in the Journal of Thrombosis and Haemostasis.
Previous work by the same group studied the dangerous clotting observed in patients with severe acute COVID-19. However, far less is known about Long COVID syndrome, where symptoms can last weeks to months after the initial infection has resolved and is estimated to affect millions of people worldwide.
The researchers examined 50 patients with symptoms of Long COVID syndrome to better understand if abnormal blood clotting is involved.
They discovered that clotting markers were significantly elevated in the blood of patients with Long COVID syndrome compared with healthy controls. These clotting markers were higher in patients who required hospitalization with their initial COVID-19 infection, but they also found that even those who were able to manage their illness at home still had persistently high clotting markers.
The researchers observed that higher clotting was directly related to other symptoms of Long COVID syndrome, such as reduced physical fitness and fatigue. Even though markers of inflammation had all returned to normal levels, this increased clotting potential was still present in Long COVID patients.
“Because clotting markers were elevated while inflammation markers had returned to normal, our results suggest that the clotting system may be involved in the root cause of Long COVID syndrome,” said Dr. Helen Fogarty, the study’s lead author, ICAT Fellow and PhD student at the Irish Centre for Vascular Biology in the RCSI School of Pharmacy and Biomolecular Sciences.
This work was funded by the Welcome Trust, the Health Research Board (HRB) Irish Clinical Academic Training (ICAT) programme as well as the HRB-funded Irish COVID-19 Vasculopathy Study (ICVS). The work was also supported by a philanthropic grant from the 3M Foundation to RCSI University of Medicine and Health Sciences in support of COVID-19 research.
“Understanding the root cause of a disease is the first step toward developing effective treatments,” said Professor James O’Donnell, Director of the Irish Centre for Vascular Biology, RCSI and Consultant Haematologist in the National Coagulation Centre in St James’s Hospital, Dublin.
“Millions of people are already dealing with the symptoms of Long COVID syndrome, and more people will develop Long COVID as the infections among the unvaccinated continue to occur. It is imperative that we continue to study this condition and develop effective treatments.”
Reference: “Persistent Endotheliopathy in the Pathogenesis of Long COVID Syndrome” by Helen Fogarty, Liam Townsend, Hannah Morrin, Azaz Ahmad, Claire Comerford, Ellie Karampini, Hanna Englert, Mary Byrne, Colm Bergin, Jamie M. O’Sullivan, Ignacio Martin-Loeches, Parthiban Nadarajan, Ciaran Bannan, Patrick W. Mallon, Gerard F. Curley, Roger J.S. Preston, Aisling M. Rehill, Dennis McGonagle, Cliona Ni Cheallaigh, Ross I. Baker, Thomas Renné, Soracha E. Ward, James S. O’ Donnell, The Irish COVID-19 Vasculopathy Study (iCVS) investigators, 10 August 2021, Journal of Thrombosis and Haemostasis. DOI: 10.1111/jth.15490
This is news? I guess the more confirming research the better.
Oh, I dunno, someone or some group of someone's be held accountable to releasing this scourge on humanity?
That'd be a start. FFS.
I notice that they don’t differentiate between vax’d and unvax’d in the “research”. My cynical mind thinks there is a reason.
I would have thought this would have been checked early on.
Next question they should be asking and testing for: Is anyone having long covid vaccine clotting response.
I don’t know if they have a way of testing for long lasting post vaccine micro clots like that Canadian Dr Charles Hoffe speculated were occuring, but they should be trying to rule that out and not just dismiss the d-dimer tests as not proof of anything.
Right now, the ire is being directed to the unvaccinated. I didn't send money to the Chinese to study develop this bioweapon. I didn't release this bioweapon on humanity. I didn't make some hokey spike protein "vaccine" to force upon the public. I didn't profit from said "vaccine". But somehow, I'm responsible for the mandates (also I didn't issue) and/or lockdowns.
Yes. A doctor in Canada found 63% of people who got the shot had tiny tiny clots at the capillary level. Story was on here about a week ago.
Validation. Get it before it’s pulled as ‘misinformation’.
I labeled the spike protein a blood toxin months ago and asserted that the virus is nothing more than a delivery agent for the engineered spike protein, i.e. a biological weapon.
I guess a little progress is still progress...
No direct refs to vax
“syndrome, and more people will develop Long COVID as the infections among the unvaccinated continue to occur. It is imperative that we continue to study this condition and develop effective treatments.””
Note the gratuitous vaccine comment.
I know someone who has it. She was always posting “wear your mask, etc” but she got Covid anyway. Combining Covid with her medded Anxiety basically turned her into a zombie. Now she is always “exhausted”, “overwhelmed” and struggling with her “mental health” just like everyone else these days.
No he found that 63% of people had elevated d-dimer tests. WHich indictate an elevated breakdown of fibrin byproducts. Doesn’t necessarily mean they have clots.
But it could mean that, it’s a concern that should be looked into further.
Dr. Charles Hoffe discusses the D Dimer test and Vaccine patients:
And so I am still trying to accumulate more information. But on the ones I have so far, 62% of them have evidence of clotting. Which means that these blood clots are not rare. It means the majority of people are getting blood clots that they have no idea that they are having. So Laura Lynn, the most alarming thing about this is that there are some parts of your body like your heart and your brain, and your spinal cord and your lungs, which cannot regenerate. When those tissues are damaged by blocked vessels they are permanently damaged. So I now have 6 people in my Medical practice with reduced Effort Tolerance, which means that they just get out of breath more easily than they used to. I have one fellow that used to walk to my office every week for actually for an arthritis injection and told me that he could walk two miles without any problems, and now after a quarter of a mile he is absolutely out of breath and it has been like that for five months.
So on the basis of this D-dimer test which proves that the majority of people are clotting, these six people who now have Reduced Effort Tolerance, actually what has happened to them is that they have plugged up thousands of tiny capillaries in their lungs. And the terrifying thing about this is not just that these people are short of breath and they can’t do what they used to be able to do. But once you block off a significant number of blood vessels to your lungs, your heart is now pumping against a much greater resistance to try and get the blood through your lungs. And the problem….so that causes a condition called Pulmonary Artery Hypertension.
From FR Posted on 8/17/2021, 10:48:05 AM by SoConPubbie
Others have said that the D-Dimer test does not prove clotting. It's evidence of Fibrin breakdown products, but could come from any inflamation in the body.
Dr. Charles Hoffe, dispite his claim that the d-dimer test "proves" clotting has occurred, has not provided any evidence that I'm aware of that there are actually clots, other than the d-dimer test which others say is not proof.
I think Dr. Hoffe's concerns are note worthy and need to be looked into. But I don't think he has sufficiently made his case. It appears to be speculation based on the d-dimer test results alone. He said the micro-clots are too small to show up on a Scan.
He does point to some anecdotal cases of people with reduced Effort Tolerance. But that could be from damage that occurred due to the vaccine, due to a clot that is no longer present, or other factors. It's not proof their lungs are full of micro-clots that will remain for 3 years before killing the patients.
I recently got the first shot of Moderna, and being aware of Dr. Hoffe's concerns, I took Turmeric for it's anti-clotting effects before and after the vaccine. Despite the pharmacist telling me not to, because the anti-inflamatory effect of Turmeric could reduce the antibody response.
My wife and I have both had the virus back in November. We had little problems at the time. We know it was the virus because we keep giving blood and ARC will tell you if you have the antibodies a couple of weeks after giving. Now my wife has doesn’t have the strength or stamina from before the virus. She’s had numerous tests and scans and everything comes back negative.
...doesn’t have the strength or stamina from before the virus...
___________________________________
I had covid in March 2020.
I didn’t have anything rising to the level of Long Haul Covid, IMO, but I added 100 mg. Mega CoQ10 (Ubiquinol) 1xday It improves mitochondrial function. I noticed an improvement after the 1st dose and now take 100mg/1xday 3 days/week.
I;m 78, so I sort of expect some low energy. This was more so before adding CoQ10.
We’re up there with you. She’s 75 and I’m 76. Before the virus she was walking 4 miles a day. Now hardly any. I think when it cools down here in VA she’ll got back to maybe a mile or so. We both were taking Zinc before the virus and still do. We both do several vitamins including D. I do CoQ10 but she doesn’t. I hate to have her add any more pills to the day.
I hear you on the pills. I restrict my intake, not taking anything every day and not in the mega doses. I may increase to maximum if I feel ill, but since Covid 17 months ago, I haven’t even had a cold, nor has my husband.
I try for sunlight and for nutritious food. Right now, for example, I do not take extra D due to the season and my kefir contains about 1/4 of the daily requirement all by itself.
It’s tomato season, so I see no reason for extra C. I grow acidic strains.Leaf lettuce, romaine and endive are nearly daily intake and I prefer the slight bitterness you get this late in the season. Covers Vit. K fairly well.
I figure humans evolved in harmony with the seasons and had feasts/famines and periods when a specific food was plentiful. I try to balance with all of that in mind.
I take no prescription meds. I can tell when it’s been a few days since I took CoQ10.
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