Posted on 06/22/2021 7:45:25 AM PDT by Red Badger
Scientists at the University of North Carolina Gillings School of Global Public Health have developed a universal vaccine that protected mice not just against COVID-19 but also other coronaviruses and triggered the immune system to fight off a dangerous variant.
While no one knows which virus may cause the next outbreak, coronaviruses remain a threat after causing the SARS outbreak in 2003 and the global COVID-19 pandemic.
To prevent a future coronavirus pandemic, UNC-Chapel Hill researchers designed the vaccine to provide protection from the current SARS-CoV-2 coronavirus and a group of coronaviruses known to make the jump from animals to humans.
The findings were published in Science by lead authors David Martinez, a postdoctoral researcher at UNC Gillings School of Global Public Health and a Hanna H. Gray Fellow at the Howard Hughes Medical Institute, and Ralph Baric, an epidemiologist at UNC Gillings School of Global Public Health and professor of immunology and microbiology at the UNC School of Medicine, whose research has sparked new therapies to fight emerging infectious diseases.
The lead authors worked with a team of scientists from UNC-Chapel Hill, Duke University School of Medicine, and the University of Pennsylvania Perelman School of Medicine.
Researchers at UNC-Chapel Hill are playing a key role in coronavirus vaccine development. After testing the effectiveness of the first generation of COVID-19 vaccines, they pivoted to look at a second-generation vaccine: one that targets sarbecoviruses, Baric said.
Sarbecoviruses, part of the large family of coronaviruses, are a priority for virologists after two caused devastating disease in the past two decades: SARS and COVID-19.
The team's approach started with mRNA, which is similar to the Pfizer and Moderna vaccines used today. But instead of including the mRNA code for only one virus, they welded together mRNA from multiple coronaviruses.
When given to mice, the hybrid vaccine effectively generated neutralizing antibodies against multiple spike proteins—which viruses use to latch onto healthy cells, including one associated with B.1.351, known as the South African variant.
"The vaccine has the potential to prevent outbreaks when used as a new variant is detected," said Baric, a trailblazer in pandemic preparedness.
The paper includes data from mice infected with SARS-CoV and related coronaviruses and the vaccine prevented infection and lung damage in mice. Additional testing could lead to human clinical trials next year.
"Our findings look bright for the future because they suggest we can design more universal pan coronavirus vaccines to proactively guard against viruses we know are at risk for emerging in humans," Martinez said. "With this strategy, perhaps we can prevent a SARS-CoV-3."
Explore further
New vaccine blocks COVID-19 and variants, plus other coronaviruses
More information: "Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice," by Martinez et al. Science (2021).
science.sciencemag.org/cgi/doi … 1126/science.abi4506
Journal information: Science
Provided by University of North Carolina at Chapel Hill
Because it is always such a good idea to short circuit your immune system for fun and profit.
if it works in mice (allegedly),
then long term studies on humans are unneeded.
this must be mandated for all newborns
with royalties to the usual suspects.
...not just against COVID-19 but also other coronaviruses
—
This seems improbable as coronaviruses are an entire classification of virus which include rhinovirus, the common cold virus, flu, SARS, AIDS, swine flu, etc.
I’m good, thanks.
Look over here, don’t like the other jabs, we have a new one.
Come try it. You will like this one.
No thank you.
” Slartibartfast called the research program an “epic experiment in behavioral psychology”, however the mice were “furious” when the Earth was blown up by the Vogons mere minutes before the experiment would have been complete.”
https://hitchhikers.fandom.com/wiki/Mice
mRNA never had problems producing antibodies, they had problems when challenged with the real virus. Now they are making one that will have problems with MORE natural viruses. Good idea morons. When mRNA was first tried they thought they hit the immunity jackpot. Not so much…..
No need for vaccine. Hydroxychloroquine has been universal for over 70 years.
It would be unethical to inject innocent mice and rats with this vaccine until the human trials are over. I don’t think PETA would allow it.
Vaccine industry is a terrible horrible evil industry Bent on destroying humanity for the Global masters
They are complete and utter bull crap about immunization and anti-body formation is it entirely fraudulent and made up nonsense that they’ve been using for 60 or 70 years now
Up to recently they’ve only been murdering disabling and destroying children
Now with this communist plot COVID-19 they flash themselves upon be stupid enough Americans in world citizens that I ended it by bitch that they fed people for decades
Here is the horrible terrible awful history of the vaccine industry
You need to read the entire thing to see just how disingenuous awful and terrible that this group of evil medical people are
They use their smarts to try to get over on you
Further reading
These two incredible sites are hosted by Paradiso vaccine damage children who have made it their lifestyle over the last 15 to 20 years to educate parents about not letting the government destroy their children
You what’s a real “universal vaccine” that will protect you from ever getting infected with any virus?
Cyanide.
What is so difficult about testing different components of the viral capsid to see what elicits an immune response...choose the least toxic component...recombinantly clone it...and use that. Why continue to use the genetics of a cell?
Recent report shows that rna segments can be written back into DNA...not sure if mrna can be...but it is a segment of a larger rna molecule...so perhaps.if the dna in a germ cell gets new sequence who knows what happens if that new dna is passed on to offspring.
There has been a lot of work on how to best design a vaccine against coronaviruses in general.
By using more than one feature of the virus (epitope) to train the immune system, more viral variations can be resisted. If you pick them carefully, relatively few epitopes are needed to stimulate wide resistance across the whole family of Coronaviruses.
Some experimental vaccines that I have heard of use as few as three, others up to twelve. The Walter Reed Army Institute of Research (WRAIR) has a broad spectrum coronavirus vaccine in development, as do several other research organizations in the USA.
Whole coronavirus vaccines can produce severe and fatal reactions (such as ADE), so excluding the problematic epitopes for safety is vitally important, in addition to choosing the right ones for effectiveness.
So far, it looks very promising that vaccines will be able to be made for coronaviruses in general, but it is not a near term prospect (multi-year). If it was needed on an emergency basis however, we are pretty far down the road of figuring out how to best configure one, and mRNA technology would allow for very rapid creation and production.
👍🏼
It uses mRNA. No thank you. Go experiment on someone else.
The Mother of All Vaccines. What could go wrong?
“Universal.”
Jack-of-All-Trades and master of none.
But it’s real function is to destroy the immune system, so it’s all good.
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