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High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program
Nature Communications ^ | 25 September 2019 | David P. Labbé, Giorgia Zadra, & many others

Posted on 04/03/2021 7:52:26 PM PDT by ConservativeMind

Abstract

Systemic metabolic alterations associated with increased consumption of saturated fat and obesity are linked with increased risk of prostate cancer progression and mortality, but the molecular underpinnings of this association are poorly understood. Here, we demonstrate in a murine prostate cancer model, that high-fat diet (HFD) enhances the MYC transcriptional program through metabolic alterations that favour histone H4K20 hypomethylation at the promoter regions of MYC regulated genes, leading to increased cellular proliferation and tumour burden. Saturated fat intake (SFI) is also associated with an enhanced MYC transcriptional signature in prostate cancer patients. The SFI-induced MYC signature independently predicts prostate cancer progression and death. Finally, switching from a high-fat to a low-fat diet, attenuates the MYC transcriptional program in mice. Our findings suggest that in primary prostate cancer, dietary SFI contributes to tumour progression by mimicking MYC over expression, setting the stage for therapeutic approaches involving changes to the diet.

(Excerpt) Read more at nature.com ...


TOPICS: Health/Medicine
KEYWORDS: cancer; fat; obesity; prostate; prostatecancer; saturated; saturatedfat
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The High Fat Diet was 60% fat. The only fat that seemed a problem was Saturated Fat. Note this is not necessarily a low carb diet with the remaining 40% of carbs to protein not noted in my reading.

The supplemental Excel tables at the bottom are very detailed down to the metabolites affected and even the specific fatty acids.

It would seem cutting out some fatty acid components would reprogram the cancer in scope. Also, possibly losing weight would rectify the abnormal metabolism. Finally, it seems a key issue found was with very low methyl metabolism. This latter issue might be addressed by supplementing with methylation products, with Betaine Anhydrous (trimethylglycine) being a cheap, generally harmless provider of three methyl groups per molecule.

1 posted on 04/03/2021 7:52:26 PM PDT by ConservativeMind
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To: ConservativeMind

From just one of the supplemental tables:

https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-019-12298-z/MediaObjects/41467_2019_12298_MOESM7_ESM.xlsx

This one shows the metabolic pathways influenced, either sped up or slowed down.


2 posted on 04/03/2021 7:54:02 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

Garsh.


3 posted on 04/03/2021 7:58:27 PM PDT by HighSierra5
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To: ConservativeMind

Who paid for this study?


4 posted on 04/03/2021 7:58:41 PM PDT by dfwgator (Endut! Hoch Hech!)
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To: ConservativeMind

When you consider how delicious bacon is, this just doesn’t seem fair!


5 posted on 04/03/2021 7:58:59 PM PDT by Texan Tory (Laissez rouler les bons temps!)
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To: ConservativeMind

We will all die of some form of cancer someday. Lung, brain. Rectall, skin, liver or prostrate. Most of these can be kicked down the road so we did of something else first

Nobody gets out alive. It’s not how you die that matters; it’s how you lived


6 posted on 04/03/2021 8:00:22 PM PDT by Hodar (A man can fail many times, but he isn't a failure until he begins to blame somebody else.- Burroughs)
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To: dfwgator

Who paid for this study?

The National Vegetable Advisory Board


7 posted on 04/03/2021 8:01:23 PM PDT by Ge0ffrey
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To: ConservativeMind

bookmark


8 posted on 04/03/2021 8:02:35 PM PDT by GOP Poet (Super cool you can change your tag line EVERYTIME you post!! :D. (Small things make me happy))
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To: ConservativeMind

Sure. Right. Pass the chips!


9 posted on 04/03/2021 8:06:44 PM PDT by The MAGA-Deplorian (Democrats are lawless because Republicans are ball-less!)
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To: dfwgator

“Who paid for this study?”

PETA?


10 posted on 04/03/2021 8:07:43 PM PDT by doorgunner69 ("Those who vote decide nothing. Those who count the vote decide everything.." -Joseph Stalin)
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To: daniel1212; ckilmer

Ping of general male health interest.


11 posted on 04/03/2021 8:09:05 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: Hodar

Well said, Hodar.


12 posted on 04/03/2021 8:09:40 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

Thanks for posting! I will read it tomorrow. (Tired is stupid!!) good night!


13 posted on 04/03/2021 8:13:34 PM PDT by Pete from Shawnee Mission
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To: ConservativeMind
...are linked with increased risk of prostate cancer progression and mortality,...

So this is not a report on how HFD might increase4 the risk of prostate cancer in general population - just in those who have existing prostate cancer.

Too bad ALL men over 50 can have a few "atypical" cells in the prostate.

14 posted on 04/03/2021 8:22:14 PM PDT by corkoman
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To: ConservativeMind
increased consumption of saturated fat and obesity are linked with increased risk of prostate cancer progression

So first of all they need to control the study better to figure out if it is saturated fat -or- obesity -or- both. Or else as you were explaining if they narrowed it down to 60% saturated fat diets then this was a poorly written summary.

I don't know how one can consume a consistent diet of 60% saturated fats unless ordered to by scientists. And as you said, the effects could be neutralized by dietary modifications.

I am on a low carb diet for the last 8 or 10 weeks, but I also don't eat a lot of saturated fats. And I dropped about 20 lbs of "tire" which was annoying me. I wasn't obese but I did add some weight and am taller than average. Next month I will switch it up and add in more fruits because I love summer fruits. Mostly went on the low carb diet to get my summer swimsuit body back :-)

15 posted on 04/03/2021 8:34:07 PM PDT by monkeyshine (live and let live is dead)
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To: monkeyshine; ConservativeMind

Also to the best of my knowledge I don’t have PC, so I don’t think I need to worry about PC disease progression at this point.


16 posted on 04/03/2021 8:35:05 PM PDT by monkeyshine (live and let live is dead)
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To: ConservativeMind

Goodness gracious me. Is there anything that doesn’t cause cancer?


17 posted on 04/03/2021 8:49:50 PM PDT by Third Wheel
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To: Third Wheel

Everything Gives You Cancer...
https://www.youtube.com/watch?v=zbgXOkyF09M


18 posted on 04/03/2021 8:51:09 PM PDT by dfwgator (Endut! Hoch Hech!)
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To: ConservativeMind

Men

Ignore all prostate advice except this one

You need to get rid of your sperm every 48 to 72 hours

Prostate problems are caused by sperm just sitting around and getting old and your body not having anything to do down there

I’m not going to get into how to get rid of them ; but you need to get rid of them

I can say numerous studies over decades to prove this but I won’t

A good compilation of these studies are in the “undo it” book by Dean Ornish MD


19 posted on 04/03/2021 9:04:02 PM PDT by Truthoverpower (Fraud !!! Now we’re off the TRUMP TRAIN and on the Swamp express to communist hell !! TRUTH! )
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To: ConservativeMind

Well, given that I have been on a high fat diet for 8 years now, I will let you know if this is actually an issue. I don’t think so. A year and a half ago I was checked every possible way and nothing seemed wrong. So in 3 years I will do it again. So far, high fat means a thinner healthier me.


20 posted on 04/03/2021 9:15:48 PM PDT by poinq
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