Posted on 11/10/2020 5:30:23 PM PST by billorites
The decline in total testosterone was observed even among men with normal body mass index.
From 1999 to 2016, testosterone levels have declined in adolescent and young adult men (AYA), according to results presented at the 2020 American Urological Association Virtual Experience1.
“Overall male testosterone decline can be attributed to multiple etiologies. The United States has an aging population with older males exhibiting lower testosterone levels. Furthermore, overall population has an increase in comorbidities, including diabetes, which may have cause this testosterone decrease nationally,” Soum Lokeshwar, MD, MBA, incoming urology resident at Yale School of Medicine, New Haven, Connecticut, said during a press briefing.
“However, most of these explanations for testosterone deficiency may be attributed to age. This time-dependent decline in testosterone has not been investigated in adolescent and young adult males,” added Lokeshwar, who was at the University Of Miami Miller School of Medicine, Miami, Florida, at the time of the study.
Testosterone deficiency has a prevalence of 10%-40% among adult males, and 20% among AYA men aged 15-39 years, he added. Therefore, Lokeshwar and colleagues hypothesized that serum total testosterone levels will decline in AYA men.
The investigators used data from the National Health and Nutrition Examination Surveys (NHANES) from 1999 to 2016 to analyze serum testosterone level changes over time in 4045 AYA males. During the study periods, 3 different assays (Biotin-Streptavidin from 1999-2004, IS-Liquid Chromatography from 2011-2012, and High-Performance-Liquid-Chromatography Tandem Mass Spectrometry from 2013 onwards) were used. However, of note, they demonstrate comparable testosterone values with only some additional accuracy in the latest modality, Lokeshwar said.
After controlling for confounders—including year of study, age, race, BMI, comorbidity status, alcohol and smoking use, and level of physical activity—total testosterone was lower among men in the later (2011-2016) versus earlier (1999-2000) cycles (P < 0.001). Mean total testosterone decreased from 1999-2000 (605.39 ng/dL), 2003-2004 (567.44 ng/dL), 2011-2012 (424.96 ng/dL), 2013-2014 (431.76 ng/dL), and 2015-2016 (451.22 ng/dL; all P < .0001).
Elevated BMI was associated with reduced total testosterone levels (P < .0001), with the mean BMI increasing from 25.83 in 1999-2000, to 27.96 in 2015-2016 (P = 0.0006). Lokeshwar noted that even men with a normal BMI (18.5-24.9) had declining total testosterone levels (P < .05) during the same time frames.
Potential causes include increased obesity/BMI, assay variations
According to Lokeshwar, potential causes for these declines could be increased obesity/BMI, assay variations, diet/phytoestrogens, declined exercise and physical activity, fat percentage, marijuana use, and environmental toxins.
“We’ve seen that lower values of testosterone have been associated with increased comorbidities and an increase risk for all-cause mortality. This decline specifically, in these young adult men, with increased obesity may lead to an increase in precocious cancer,” Lokeshwar said, adding such decreases can also result in a lower libido and an increased risk for erectile dysfunction.
“This is especially worrisome in this young adult age group, as many men feel stigma and are less likely to seek care for these low libido and erectile dysfunction.” Lokeshwar added. “Testosterone levels in AYA men are used as the benchmark normal levels for testosterone. This is very scary, because generally, when we think of normal values of testosterone, we treat based upon this age group. This may ultimately lead to the undertreatment of testosterone deficiency, which can have large ramifications and severe consequences.”
I’ll betcha he can find his vagina.
Since they can’t even figure out which bathroom to use, why worry?
5 things
Certain Soy products
Female birth control pills in water supplies
Certain use of plastics
Certain chemicals
Extra body fat mimics female hormones
That explains a lot.
If Rachel Maddow had a child.....
That may be true for Dr. Sarah Hill, but not me. Effeminate men are not attractive to most women in my opinion.
Beta Boyz
Yep. Indoor video games, rather than going outside to hunt, gather and play neighborhood tackle football.
Yep soy in everything. Starting baby Boys on soy formula instead of mother’s milk.
Same here but the hair color and dressing like tramps are OK with me I just hate piercing's and fake boobs. Total turn offs.
Estrogen in the water supply? Something’s going on - young men today have higher voices than previous generations, more effeminate and delicate features (even when they can grow beards), and far too many of them are left-wingers. Something is feminizing young American men.
Many women nowadays are also fat. I don’t mind a woman getting fat if she’s my wife, and got that way by giving birth to my children, but it’s a big turn off if they are single, and I’m looking.
That’s the No Fault divorce, and being raised by their mothers.
Nothing in nature is absolute but if there is a statistically significant influence on the decisions that women make for sexual partners then there will be an effect over the long term. Oral contraceptives have been around since 1960, over 60 years, and even small changes of women’s partner preferences over 3 generations could have a significant effect.
How else do you explain the sackless wonders in this picture?
What is a guy supposed to do with a nipple that has a nail stuck through it?
Same goes for stretch marks. If I am responsible for them I have no problem with them, kinda sexy. When I am dating and a woman has stretch marks who didn’t bear my children, total turn off.
There's a song out there on youtube that explores that question. (WARNING - NOT FOR KIDS!)
"No Balls At All" - Iris and Rose
Beat me to it.
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