Posted on 04/07/2020 4:55:52 AM PDT by Sarcasm Factory
At the risk of upsetting a few folks, someone who appears to be in the know has tossed a small bucket of cold water on the notorious hydroxychloroquine and azithromycin drug cocktail:
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First up is this study from France. It’s another very small one, and all the usual warnings apply because of that. It’s from a team at the University of Paris and Saint-Louis Hospital there, and they evaluated 11 consecutive patients admitted there with the same course of treatment as the Marseilles group first reported (hydroxychloroquine 600mg/day and azithromycin, 500mg the first day and 250 mg/day thereafter). The mean age of their patients was 58.7 years, and (notably) 8 of the 11 had significant comorbidities (two obese, 5 with various forms of cancer, one with HIV). That’s a tough population, and unfortunately, the HCQ/AZ combination did nothing. One patient died (and two others went on to the ICU) and of the ten remaining, 8 were still positive for the virus by nasal swab on days 5/6 after treatment. One patient had to discontinue therapy on day 4 because of QT prolongation, a known side effect of hydroxychloroquine that can lead to fatal heart arrhythmia.
So while this is a small study and not a perfect match, it provides no evidence to show that the HCQ/AZ combination had any benefit at all. While we’re on the subject of QT prolongation, there’s this preprint from a medical team at NYU that was also treating patients with the same combination of drugs. In 84 patients, they found notable QT prolongation in about 30% of them, and another 11% were to a level (>500 milliseconds) that put them at a high risk for arrhythmia. This group’s mean age was 63, 74% male. No cancer patients in this group, but 65% did have hypertension and 20% were diabetic (which from many reports is actually a reasonable look at the patients most likely to progress to severe disease). The strongest predictor of dangerous QT numbers was the development of renal trouble while on the drug combination.
There are a couple of other things that need to be noted. One is that hydroxychloroquine itself actually lowers the activity of the innate immune system; that’s why people take it for lupus and for rheumatoid arthritis. Many people are saying that perhaps it will work best if taken early in the course of infection, but this effect (which is mediated through TLR receptors) should be kept in mind. Another potentially important point is raised in this preprint – which, it has to be said, is not human data but mouse toxicology. But with that in mind, the authors report what looks like a bad interaction in that species between HCQ and metformin. And by “bad”, I mean about 30% mortality. If this translates at all to humans, it could be bad news, because (as mentioned above) diabetics look like a high-risk group and many patients may well have been taking metformin when they present at the hospital. We need more information on this. An investigational drug combination that showed this effect in mice would not move forward in the normal course of things.
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One of the effects of the Hydroxychloroquine is to enhance the ability of cells to absorb zinc. The zinc then inhibits the ability of the virus to reproduce.
You Are the first to reference Metformin. Could you please be more specific as to why you think it’s poison? My daughter is on it and all it’s done is made her sluggish and gain weight. Please private email me if you’d rather.
YES, YES, YES!
ZINC, ZINC, ZINC!
ZINC is the CURE, HCQ is the vehicle. ZPAK unnecessary.
My observations:
1) Metformin cause me to have BAD intestinal problems (gas, bloating, diarrhea)
2) weight gain. Once I got off, dieting started to work again.
3) Metformin can cause pancreatitis (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3106398/) I had a bout of pancreatitis but from a different cause. However, I was not going to take something that would aggravate my pancreas.
4) https://healthprep.com/medications/side-effects-metformin/?utm_source=google&utm_medium=search&utm_campaign=8670706552&utm_content=93184594443&utm_term=side%20effects%20of%20metformin&gclid=EAIaIQobChMIy_jU2cfW6AIVD9VkCh0usApREAMYASAAEgK-8_D_BwE
5) My personal observations of individuals 5 years and 10 years on Metformin showed significant degregation in their overall health
They do make diet tonic water but I wouldn’t want to have to drink gallons of that either.
Yeah, they keep leaving out the zinc which, according to the French doctor and Zelenko, is most important.
As BP was alo noted, wonder how hydroxychloroquin interacts with Ace2 inhibiting blood pressure meds as that is the mechanism Covid-19 infiltrates. Or even if such BP meds increase or decrease susceptibility to virus.
Last thing anyone should put in their bodies is any artificial sweetener. It is poison.
Every time I see Trump with a diet coke I want to shake him.
zpak (not zpak because zpak is a certain declining dosage, but that antibiotic) is what causes the potential heart problems. Doxycyclene does the same thing and is safer for preventing opportunistic infections because there is no heart risk. Zpak has some very minor antiviral activity but I dont think it makes a whits-worth of difference in the outcomes.
I suspect they would be better off giving a dose of Zinc Picolinate rather than sulfate because that has been shown to have some ability to pass cell walls on its own. HCQ would supercharge it. https://www.ncbi.nlm.nih.gov/pubmed/3630857 At least in hair cells and red blood cells** it passes and it should pass the cell wall in all cells in a study. I would also change to doxy to eliminate cardiac risk in at risk patients.
**Covid attacks red blood cells and their hemoglobin which is part of why people die to boot.
I am on Zinc Picolinate and Quercitin (Another Zinc tunnel maker like HCQ but not as potent) and vitamin D3 as my prophylaxis. (D3 shown in large doses to reduce both catching a viral pulmonary disease by 20% and its severity if you do catch it and deficiency increases risk by like 70%)
Without the zinc, its like driving a car with no wheels.
Chloroquine is an Zinc Ionophore
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0109180
But, good to know about the possible interaction with Metformin..
That’s what I am now seeing in my daughter. Thank you
I got off of Metformin and started with Jardiance and Tradjenta. Then focused on getting off the weight. Went from 260 lbs down to about 195 / 200 lbs currently. Also went to Adkins diet and now on Keto as my sustain diet. I am using the stair step diet. Take 20 lbs off, then stabalize at that weight. Then repeat. I have another 20 lbs to drop before I get back to my Army weight. That is this summer’s self-improvement project. Not bad progress for a guy that is 55 years old.
I highly recommend the following:
Organo Gold coffee / tea - available from the company, from their MLM marketing distributors but I buy it from Amazon. It helps curb the cravings for sweets and clears out the intestines.
Add a calcium, magnesium, zinc, vit D supplement - I get the Kirkland brand generic from Costco.
Just recently added a K2 vitamin supplement. I have noticed that I am less tired and getting better sleep. Feet are less twitchy which can sometime accompany diabetics.
Well yes, if Metformin has a bad reaction with HCQ, we shouldn’t give it to people who are on Metformin. That seems like an obvious thing, as there are hundreds of drug combinations that are really bad, and we try very hard to NOT prescribe them together.
I do love how people who complain that a 100-person test isn’t any good if it didn’t have a double-blind setup, think that an 11-person study where they had no controls at all is a good thing.
Lastly, in the study of 11 people, of whom 8 were expected to die because of multiple bad conditions, and 3 were unknown but one of those actually DID die before the treatment really got started, 2 people were healed before 8 days.
I think you and wish you continued success with your diet
Not a healthy choice but a lot of diabetics and some ill-advised weight watchers resort to it. I wish they’d just make reduced sugar stuff.
“red blood cells and their hemoglobin”
We know someone fairly young who had this thing. He’s all over the covfefe orientation and high-altitude oxygen deprivation ideas.
In a world where humans with a penis are considered female, yes. That is how ir works.
hydroxychloroquine is called an ionophore, it softens up the virus for the zinc to enter and kill the virus. Zinc is a cold remedy. But neeeds help from hydroxychloroquine to get into Covid
>>>>>>>Zinc binding compounds, especially zinc ionophores, are a new group of potential anticancer agents that target zinc to the lysosomes and induce lysosome-mediated apoptosis of cancer cells. In addition, the role of zinc in regulating autophagy has been recently realized. Chloroquine Is a Zinc Ionophore - PubMed Central (PMC) www.ncbi.nlm.nih.gov/pmc/articles/PMC4182877/
I agree
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