Posted on 09/18/2019 12:59:13 PM PDT by Red Badger
Prescribing metformin and vildagliptin to people newly diagnosed with type 2 diabetes reduced their long-term blood sugar levels more than single-drug therapy in a recent study.
Sept. 18 (UPI) -- When it comes to controlling early symptoms of type 2 diabetes, two drugs are better than one, a new study says.
Prescribing metformin and vildagliptin to people newly diagnosed with type 2 diabetes reduced their long-term blood sugar levels more than single-drug therapy, according to findings published Wednesday in The Lancet. The patients also had lower rates of treatment failure than those who only used Metformin, the current first-line drug used by new type 2 diabetics.
"The findings of VERIFY support and emphasize the importance of achieving and maintaining early glycaemic control," the authors wrote.
The VERIFY study was also presented at the Annual Meeting of the European Association for the Study of Diabetes in Barcelona.
Researchers recruited 2,001 patients in 254 medical centers in 34 countries, randomizing 998 to receive the early combination therapy and 1,003 who only received metformin.
Some patients took a combination therapy of one daily dose of between 1,000 and 2,000 milligrams of metformin and a twice-daily dose of 50 milligrams of vildagliptin. The monotherapy group took the same daily dosage of metformin and placebo twice a day.
The patients had their HbA1c blood sugar levels monitored every 13 weeks.
Anyone in the monotherapy group whose HbA1c levels rose above 53 mmol/mol during two consecutive monitoring sessions had a treatment failure. They were then prescribed the combination therapy.
Those in the early combination therapy group whose levels went above 53 mmol/mol just continued the regime.
Nearly 44 percent of patients in the early combination group had treatment failure versus more than 62 percent of patients in the monotherapy group.
If either group had another failure after two more monitoring sessions, they were placed on insulin treatment.
The early combination group had half the likelihood of losing blood sugar control than the monotherapy group. They also had a 26 percent lower risk of having HbA1c levels above 53 mmol/mol than the group moved from monotherapy to combination therapy after first treatment failure.
"Early intervention with a combination therapy strategy provides greater and durable long-term benefits compared with the current standard-of-care monotherapy with metformin for patients with newly diagnosed type 2 diabetes," the authors wrote.
I went with high protein, low fat, and only 20G of carbs per day.
I’m eating alot less and dropped some serious weight.
Haven’t felt this good in a long time.
*** ““Type 1 or Type 2?” ***
*** “It doesn’t matter. The answer is the same” ***
I beg to differ, one is an organ shutdown the other is Chronic Inflammation.
*** “I went with high protein, low fat, and only 20G of carbs per day” ***
Curious, Low Fat ... your appetite, are you hungry?
How many times do you eat a day?
There are so many sugar substitutes it should not be hard. There are questions about some of the more common ones like Aspartame, but now there are completely organic/herbal ones like Stevia and Monks Fruit. The first time I tried Atkins in 2006 after my husband died of Alzheimers I had gone up to 165 lbs because I would have to get this 200 lb man back into bed at 4 am when he wanted to go out and walk the city streets. I was a little under 5’5” and after a year of careful eating I was down to 155 lbs. Then I visited family and saw an Atkins diet book. The scientific rationale made sense, and there ws lots of good Atkins info on line. In 3 months I lost another 15 lbs to 140, and then more slowly to 130. Then life got complicated and more stressful again and I crept back to 150. Last January I got serious and started Atkins at 20 carbs a day. I got back to 135, but have really been moving very slowly to 128. My stable weight from late teens to childbearing at 31 had been 123 lbs. I don’t know if I will make to there, but am eating 30 to 50 grams of carbs a day now.
I have started eating Chia seed pudding. I put 2 tablespoons of seeds in a dish, add 1/4 cup of 1/2 and 1/2 milk/cream. Stir it every few minutes while the seeds absorb the liquid, add a little more liquid if needed. Add a packet of Monks Fruit sweetner, a few drops of Vanilla or a dash of Cinnamon, and sometimes a teaspoon of sugar free jam or jelly. Chew thoroughly to break up the tiny seeds to get the nourishment inside. Chia is very nutritious. The Indians used to carry a small bag of dry seeds to chew on during long trips.
The Atkins diet does work, and it is similar to the glycemic index diet required for diabetes.
Where did you go to medical school?
You take some facts and come up with the wrong conclusion.
Once again, Diabetes is NOT caused by diet or anything else a person has control over.
It IS inherited.
You are confusing symptoms with cause.
Blame me all you want. But you can KMA you self righteous blowhard.
“*** ““Type 1 or Type 2?” ***
*** “It doesn’t matter. The answer is the same” ***
I beg to differ, one is an organ shutdown the other is Chronic Inflammation.”
Wow, you sure do like to twist things. I said diabetes is inherited, you ask which type, I say it doesn’t matter. So you come back by disagreeing with an entirely different thing.
Both types are indeed inherited. A person with diabetes did not cause their own disease. What a person eats has a great deal to do with the body’s response to the disease but you don’t cure it nor did you cause it, by what you do or do not eat. Being symptom free does not equal disease free.
Free Republic used to be a nice place. Now it is full of self important, self righteous, uneducated assholes.
Not hungry at all. I eat 3 x a day.
I just stay away from sugars and carbs.
Had a granola bar for break, 2 eggs for lunch, ribs for dinner
165? I haven’t been 165 since I was in Boot Camp in 1974!
I would have to go on a starvation diet to ever see 165 again!..............(or 200).............
Keep up the good work!......................
*** “Free Republic used to be a nice place. Now it is full of self important, self righteous, uneducated assholes” ***
(You left out Close Minded)
Quick search and exactly what you addressed is explained here
https://www.youtube.com/watch?v=A5Oi1W3KtIk
It is about 17 minutes or you can just get back to your Pity Party
Bkmk
Where did you?
"Once again, Diabetes is NOT caused by diet or anything else a person has control over."
That's just flatly wrong. I don't know where you're getting it.
Maybe you feel better thinking it was unavoidable. But you might instead take some hope from the idea you can improve things. It's not about blame. I'm telling you there's something you can do about it. It ought to be worth some serious thought at least.
It also has people that have specific knowledge about specific fields. Sometimes they tell you things you didn't know. Try to keep that in mind.
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