Posted on 09/18/2019 12:59:13 PM PDT by Red Badger
Prescribing metformin and vildagliptin to people newly diagnosed with type 2 diabetes reduced their long-term blood sugar levels more than single-drug therapy in a recent study.
Sept. 18 (UPI) -- When it comes to controlling early symptoms of type 2 diabetes, two drugs are better than one, a new study says.
Prescribing metformin and vildagliptin to people newly diagnosed with type 2 diabetes reduced their long-term blood sugar levels more than single-drug therapy, according to findings published Wednesday in The Lancet. The patients also had lower rates of treatment failure than those who only used Metformin, the current first-line drug used by new type 2 diabetics.
"The findings of VERIFY support and emphasize the importance of achieving and maintaining early glycaemic control," the authors wrote.
The VERIFY study was also presented at the Annual Meeting of the European Association for the Study of Diabetes in Barcelona.
Researchers recruited 2,001 patients in 254 medical centers in 34 countries, randomizing 998 to receive the early combination therapy and 1,003 who only received metformin.
Some patients took a combination therapy of one daily dose of between 1,000 and 2,000 milligrams of metformin and a twice-daily dose of 50 milligrams of vildagliptin. The monotherapy group took the same daily dosage of metformin and placebo twice a day.
The patients had their HbA1c blood sugar levels monitored every 13 weeks.
Anyone in the monotherapy group whose HbA1c levels rose above 53 mmol/mol during two consecutive monitoring sessions had a treatment failure. They were then prescribed the combination therapy.
Those in the early combination therapy group whose levels went above 53 mmol/mol just continued the regime.
Nearly 44 percent of patients in the early combination group had treatment failure versus more than 62 percent of patients in the monotherapy group.
If either group had another failure after two more monitoring sessions, they were placed on insulin treatment.
The early combination group had half the likelihood of losing blood sugar control than the monotherapy group. They also had a 26 percent lower risk of having HbA1c levels above 53 mmol/mol than the group moved from monotherapy to combination therapy after first treatment failure.
"Early intervention with a combination therapy strategy provides greater and durable long-term benefits compared with the current standard-of-care monotherapy with metformin for patients with newly diagnosed type 2 diabetes," the authors wrote.
Actually this was nearly 20 years ago now. It was the standard diet for diabetes. As little fat as possible (so you’re always hungry) and stuff yourself with carbs. Don’t worry about your blood sugar, we will ‘control’ those (for some value of you’re on a never ending uphill treadmill of increasing dosage and number of pharmaceuticals) with meds...
Take a look at this timeline of Insulin, and ask yourself when America GOT FAT, in 1978 I got out of High School and My whole childhood Obesity and FAT Kids for the most part didn’t exist
https://www.diabetes.co.uk/insulin/history-of-insulin.html
You are definitely doing it right...
I wonder how many posts before some self rightous A-hole comes along and tells me it is my fault I have diabetes.
Of course, they will likely be the same A-holes who say it is my fault I have chronic cluster headache syndrome too.
Well that answers my question.
Ten. The answer is Ten.
*** “My morning fasting blood sugar has been between 85 and 95” ***
That is about my avg too... I don’t take Metformin but I do supplement w 500MG Berberine about 3 times a week (if I think about it)
Your weight loss is awesome, I’m about 35lbs behind you but fishing and beer does get in my way from time to time... That Ultralight 2.6G Carb does allow me to feel less guilty and enjoy my friends and fishing as long as that good voice in my head keeps telling me “Beer is liquid bread”
Excellent!
*** “I wonder how many posts before some self rightous A-hole comes along and tells me it is my fault I have diabetes” ***
Type 1 or Type 2?
The food pyramid has had a lasting effect in the medical community. When my husband was diagnosed, his doctor referred him to a dietician, who put him on a low calorie, low fat, high carb diet. It was a disaster.
But it made the food and pharma companies rich, so there’s that.
I’m amazed that there are some who still are pushing a diet that is not only bogus but unhealthy as well-it is willful ignorance...
Exactly.
Lately the VA tells all type 2 vets that were anywhere in the vicinity of Vietnam that their type 2 is Agent Orange caused. Even if they never stepped foot off a ship or off their bases or ever went into a sprayed area or were around any storage or spraying equipment. That is some powerful herbicide, even Roundup weed killer isn't that effective.
It is a good thing you and your husband pursued the Atkins/low carb way of eating and averted disaster...
The food pyramid has had a lasting effect on people who didn’t either grow up on a ranch/farm or had parents who were organic food types-those kids learned to eat healthy and are not obese unhealthy, etc-there are very few fat people to be seen out here-nearly all of them are tourists/daytrippers from the city-and many of their kids are fat, too-the local grocery caters to the natural/fresh organic food crowd here-so the tourists usually just hit the bakery, deli and snack aisles before waddling off to the river or lake...
Whoever paid for and began the promotion of that food pyramid should be sued into oblivion in a class action lawsuit-they have done some real harm...
My first A1c this year was in January with a 7.4 result. I lost about 25 lbs. over the next few months and revised my med schedule to take my Glipizide right before a meal. By May, my A1c was at 6.5. In June, I was taken off of Metformin due to an adverse kidney function test. I only have one kidney due to a non-malignant tumor that caused the loss of my left kidney several years ago. Now my only meds are 10mg Glipizide am and again in the pm. It seems to be finally doing the trick as long as I’m really diligent on the diet side of things.
I couldn’t agree more. Thanks, Texan5!
Absolutely. Evil people.
Cutting way back on carbs to reverse diabetes ONLY works for people who try it. It doesn’t work for others.
LOL!
I just returned from our company’s Health Awareness dog & pony show. A dietition had a table display with 200? calorie baggies of CARB food, some candy like M&Ms but with veggies too.
I mentioned that calories alone does not lower weight. That humans CANNOT burn off enough calories through exercise.
I mentioned Intermittent Fasting - she was ognorant!
I asked, where is the meat? - ignorance.
I mentioned Insulin the Fat hormone - ignorance.
She did NOT know that Sugar makes you FAT ! She gave advise to others.
An accredited Dietition but ignorant about diet, everything was low fat calories.
America, advertising, food pyramid, ignorant people equals disasterous sick people.
Cable TV is YOUR ENEMY, they sell drugs that make you sick.
Generally.
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