Posted on 08/26/2011 1:12:38 PM PDT by Swordmaker
Alzheimer's disease - a neurospirochetosis. Analysis of the evidence following Koch's and Hill's criteria.
Judith Miklossy
Correspondence: Judith Miklossy judithmiklossy@bluewin.ch
Journal of Neuroinflammation 2011, 8:90 doi:10.1186/1742-2094-8-90
Published: 4 August 2011
Abstract (provisional)
It is established that chronic spirochetal infection can cause slowly progressive dementia, brain atrophy and amyloid deposition in late neurosyphilis. Recently it has been suggested that various types of spirochetes, in an analogous way to Treponema pallidum, could cause dementia and may be involved in the pathogenesis of Alzheimer's disease (AD). Here, we review all data available in the literature on the detection of spirochetes in AD and critically analyze the association and causal relationship between spirochetes and AD following established criteria of Koch and Hill. The results show a statistically significant association between spirochetes and AD (P = 1.5 x 10-17, OR = 20, 95% CI = 8-60, N = 247). When neutral techniques recognizing all types of spirochetes were used, or the highly prevalent periodontal pathogen Treponemas were analyzed, spirochetes were observed in the brain in more than 90% of AD cases. Borrelia burgdorferi was detected in the brain in 25.3% of AD cases analyzed and was 13 times more frequent in AD compared to controls. Periodontal pathogen Treponemas (T. pectinovorum, T. amylovorum, T. lecithinolyticum, T. maltophilum, T. medium, T. socranskii) and Borrelia burgdorferi were detected using species specific PCR and antibodies. Importantly, co-infection with several spirochetes occurs in AD. The pathological and biological hallmarks of AD were reproduced in vitro. The analysis of reviewed data following Koch's and Hill's postulates shows a probable causal relationship between neurospirochetosis and AD. Persisting inflammation and amyloid deposition initiated and sustained by chronic spirochetal infection form together with the various hypotheses suggested to play a role in the pathogenesis of AD a comprehensive entity. As suggested by Hill, once the probability of a causal relationship is established prompt action is needed. Support and attention should be given to this field of AD research. Spirochetal infection occurs years or decades before the manifestation of dementia. As adequate antibiotic and anti-inflammatory therapies are available, as in syphilis, one might prevent and eradicate dementia.
The complete article is available as a provisional PDF. The fully formatted PDF and HTML versions are in production.
Thanks for the tip.
Cheers!
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And you sir, are apparently a clod.
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A worthwhile ping; thank you!
Missed out on that role in the Smurf movie?
No, sir. When you give out worthless, inaccurate facts, that fly in the face of science and the easily found truth, your opinion is WORTHLESS! PERIOD. I posted the science and the engineering and you come on and post your worthless opinion that stated that it was "abrasive" when it clearly is NOT. PERIOD. You, sir, are the clod. I am speaking with authority, from the industry with expertise, you are not.
Mark for later.
A heart-felt thank you bump for another review.
Sorry, I do not have PDS. I try to point out where the Palin fanatics are not dealing in reality. They say outrageous things and make outrageous predictions based solely on emotion.
The data he shares on sodium bicarbonate and sodium hypochlorite use makes perfect oral hygiene sense -- including the low probability of scratching dental materials.
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Sorry, trisham; facts win this round...
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The oral spirochete - Alzheimer's link is news to me, but I intend to explore the subject with great interest. (My father and one of his sisters had Alzheimer's...)
Bottom line: I see virtually zero risk and potentially tremendous benefits from following Swordmaker's's oral hygiene recommendations...
Swordmaker, thank you! And, please update us as you become aware of new data!
I shall do that... and thanks for the support on the materials.
>>And you sir, are apparently a clod. <<
Amen to that.
I’m not quite sure what this poster does at “His doctor’s office” but I hope it isn’t dealing with patients.
BTTT
I hear tell he's somewhat of a computer guru... '-)
>>No, sir. When you give out worthless, inaccurate facts, that fly in the face of science and the easily found truth, your opinion is WORTHLESS! PERIOD. I posted the science and the engineering and you come on and post your worthless opinion that stated that it was “abrasive” when it clearly is NOT. PERIOD. You, sir, are the clod. I am speaking with authority, from the industry with expertise, you are not. <<
You’re a smarmy ass, who while attempting to pass along good science, is showing the elitist tendencies of our President. Good job, Watson. You’ve spent half the thread insulting people. What exactly IS your job in this dental office? You’re not a dentist, what are you?
I think that is a really good idea! We have a water pic. My daughters just came through braces.
I’ll be praying for you!!!
Ping.
>>I hear tell he’s somewhat of a computer guru... ‘-) <<
Good thing. Cause if he had to deal with patients, he would go to bed hungry.
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