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Healthy gut flora could prevent obesity (and more)
Lund University ^ | May 25, 2011 | Unknown

Posted on 05/25/2011 9:29:04 AM PDT by decimon

Poor gut flora is believed to trigger obesity. In the same way, healthy gut flora could reduce the risk. This has shown to be the case in tests on rats.

Daily intake of a lactic acid bacteria, which has been given the name Lactobacillus plantarum HEAL19, appears to be able to prevent obesity and reduce the body's low-level inflammation.

"Rats who were given this specific lactic acid bacterium from their time in the uterus up to adult age put on significantly less weight than other rats. Both groups ate the same amount of high-energy food", explains Caroline Karlsson, a researcher in food hygiene at Lund University.

Ms Karlsson also observed that the rats which were given lactobacilli had a richer and better composition of the bacteria which occur naturally in the intestines. A healthy gut flora should contain a large proportion of 'good bacteria', such as lactic acid bacteria, in order to keep the inflammation-causing bacteria in check.

A third group of rats were given the inflammation-causing Escherichia coli bacteria in their drinking water, in addition to the same high-energy food as the other rats. The E. coli supplement led to changes in gut flora and increased body fat. The findings were published recently in the British Journal of Nutrition and form part of the doctoral thesis that Caroline Karlsson recently presented.

In another study, Caroline Karlsson has studied the first faeces of 79 children born vaginally. A foetus lives in a sterile environment and therefore has no micro-organisms in its intestines, but during birth the baby swallows the lactobacilli that are naturally present in its mother's vagina.

"It had not previously been shown that all newborn babies born vaginally have lactobacilli in their gut flora as early as two days after birth. Thanks to the application of a gene-based technique, we have been able to show in our study that this is in fact the case", says Caroline Karlsson, who also found that babies with high birth weight had more inflammation-causing bacteria, such as E. coli, in their intestines than babies of normal weight.

A healthy gut flora at an early stage appears to play a part in children's wellbeing later in life. This is a conclusion in a further study, where Caroline Karlsson showed that children with allergic eczema at the age of 18 months had a lower diversity in the gut flora when they were just one week old compared with the children who did not develop allergic eczema.

In the aforementioned study on rats, it emerged that the mother's diet and bacteria consumption affect the development and health of her young.

"A number of female rats were given food with high energy content during pregnancy and while they were suckling their young. We saw that, at two weeks of age, the young whose mothers were given high-energy food had higher body weight and more fat in their bodies, as well as higher levels of inflammation, than young whose mothers were given a more balanced diet", explains Caroline Karlsson.

The research was financed by Formas.

Caroline Karlsson defended her thesis, The Gut Bacterial Flora - Focus on Early Life and Physiological Traits on Friday, 6 May at Kemicentrum, Lund University. Read a summary (PDF in English available near the top of the linked page. Scroll down the linked page for English abstract summary). For more information

Professor Siv Ahrné, Applied Nutrition and Food Chemistry, +46 46 222 83 27, +46 703 484 516, Siv.Ahrne@appliednutrition.lth.se, or Professor Göran Molin, Applied Nutrition and Food Chemistry, +46 46 222 83 27 (same telephone number as Siv Ahrné), Goran.Molin@appliednutrition.lth.se.

Caroline Karlsson can be contacted on caroline.karlsson@appliednutrition.lth.se, +46 46 222 83 26.

High-definition photographs of Caroline Karlsson are available in the Lund University image bank. Enter "Caroline Karlsson" in the search field. About probiotics

Probiotics is an umbrella term for bacteria with proven health benefits. They are important for the prevention of various stomach and intestinal problems. Research findings also indicate that probiotics could affect the immune system, relieve eczema and help fight viral infections.

"Certain foods, for example olives, yoghurt and cheese, naturally contain lactobacilli - the type of bacteria most often used as probiotics. Such bacteria were more common in the past, when food was fermented to extend its shelf life. Today, when fridges and heat treatment of food kill off both harmful and beneficial bacteria, we ingest too little of the "friendly bacteria", explains Göran Molin.

The lactic acid bacteria Lactobacillus plantarum HEAL19 has been isolated from healthy intestinal mucous membranes in humans. It is patented but is not used as an additive in any food products. Examples of probiotic bacteria used by the food industry are: L. plantarum 299v, L. plantarum HEAL9, L. paracasei 8700:2, L. paracasei F19. These all belong to the same bacterial genus.


TOPICS: Food; Health/Medicine; Science
KEYWORDS: health; hfcs; lactobacilli; medicine; obesity; probiotics
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To: decimon

My daughter has Crohn’s and probiotics absolutely help. The best one we’ve found is Garden of Life-Primal Defense ULTRA. It has the largest variation of different probiotics and in sufficient amounts. I can’t say whether it helps her weight or not.


21 posted on 05/25/2011 11:03:29 AM PDT by chuckles
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To: Albion Wilde

I tried that yogurt once and it played havoc with my GI tract. Perhaps it takes the body some time to adjust....


22 posted on 05/25/2011 11:10:44 AM PDT by Bigg Red
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To: Netizen

My body sure can tell the difference. And my intestines do not like the HFCS.


23 posted on 05/25/2011 11:13:45 AM PDT by Bigg Red
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To: Uncle Miltie

Yuck! Please don’t show me her, as I will not want to eat yogurt.


24 posted on 05/25/2011 11:15:56 AM PDT by Bigg Red (Palin in 2012)
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To: decimon

Yogurt ping


25 posted on 05/25/2011 11:26:03 AM PDT by diamond6 (Check out: http://www.biblechristiansociety.com/home.php and learn about the faith.)
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To: decimon


26 posted on 05/25/2011 11:33:29 AM PDT by JoeProBono (A closed mouth gathers no feet)
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To: martin_fierro

Is that an AFLAC commercial?


27 posted on 05/25/2011 11:42:01 AM PDT by Rebelbase
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To: Bigg Red

The sad thing is that they are sticking it in everything. You have to really read the labels. I bought some red kidney beans and found that they have HFCS. Won’t be buying that brand again.


28 posted on 05/25/2011 11:58:52 AM PDT by Netizen
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To: Netizen

Oh, I know. It is very hard to find many products that don’t have HFCS. Hunt’s ketchup now has a banner on the label declaring no HFCS is in it.


29 posted on 05/25/2011 5:32:20 PM PDT by Bigg Red (Palin in 2012)
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To: Bigg Red
I tried that yogurt once and it played havoc with my GI tract. Perhaps it takes the body some time to adjust....

Yep -- a few days. Best to start it on a weekend or vacation.

But "gut" health is important. Certain substances not cleared out and fermenting in there can literally make a person intoxicated and feel drugged or exhausted.

30 posted on 05/26/2011 8:46:23 AM PDT by Albion Wilde (Thank you, Dubya and U.S. military. You did not falter. You did not fail.)
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To: decimon

Here is a recipe for making your own yogurt. It works well. I tried it. But I do prefer the stove-top method. Stove-top makes a thicker type. Either way, it takes 100% better than store bought!

http://crockpot365.blogspot.com/2008/10/you-can-make-yogurt-in-your-crockpot.html

I was scared to try it at first, but once I did, YUM! Cost effective, too!


31 posted on 05/26/2011 8:56:53 AM PDT by daisy mae for the usa
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To: daisy mae for the usa
I was scared to try it at first, but once I did, YUM! Cost effective, too!

Isn't is awesome?! I found that recipe a few weeks ago and gave it a shot and LOVE it. I like the consistency because I mainly use it in my morning fruit smoothie. Where I used to use milk + yogurt + fruit, now I just use the yogurt and fruit. Like you, I was nervous trying it at first but no ill effects and it is SO much yummier than store bought.

32 posted on 05/26/2011 9:16:52 AM PDT by meowmeow (In Loving Memory of Our Dear Viking Kitty (1987-2006))
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To: Netizen

It does take a while for your body to adjust - it was about two weeks of irritation and an uninhabitable bathroom when I started (wife kept nagging me to try it).
Once you get through that, yes, you do feel better.

Can’t suggest a way for you to avoid HFCS in food though other than avoid tinned goods altogether. It is an illegal additive over here and through most of Europe, make of that what you will.


33 posted on 05/26/2011 3:26:05 PM PDT by EnglishCon
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To: daisy mae for the usa

Thank you, going to give that a try!

I use the classic fridge and starter culture method, but your recipe looks not only nicer, but easier too, fridge space always being at a premium!


34 posted on 05/26/2011 3:28:36 PM PDT by EnglishCon
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To: Paladin2

Absolutely makes more sense and I can attest to the truth of this matter. To battle Lyme Disease, I took enormous doses of 5 different antibiotics for almost 3 years. I never needed to watch my weight before then. During the time that antibiotics were a food group for me, weight gain was a problem.


35 posted on 05/26/2011 3:31:59 PM PDT by JustaDumbBlonde (Don't wish doom on your enemies. Plan it.)
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To: meowmeow

Glad to see someone else enjoying it! I’ve have tried it with protein drinks to. That worked well, also. Maybe others will give it a shot!


36 posted on 05/26/2011 3:38:42 PM PDT by daisy mae for the usa
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To: EnglishCon

Glad to help! :) Here’s to happy flora in our stomachs and happy fauna in our gardens!!!


37 posted on 05/26/2011 3:41:17 PM PDT by daisy mae for the usa
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To: decimon
"Rats who were given this specific lactic acid bacterium from their time in the uterus up to adult age put on significantly less weight than other rats. Both groups ate the same amount of high-energy food", explains Caroline Karlsson, a researcher in food hygiene at Lund University.

If the rats actually ingested exactly the same amount of the same food, about the only thing this could mean is that the lactic acid bacterium-laden rats absorbed less nutrients through their guts than the other rats, resulting in the difference in weight/fat between the two groups.

Feed was administered ad libitum, and the consumption per cage was recorded once a week.

But, now that I've read the paper, the rats didn't eat the same amount of high-energy food. They were allowed to feed on the same high-energy food ad libitum, which means whenever they felt like eating it. So the mechanism may be that certain bacteria resulted in an increase in appetite, the Ec rats, or helped to restrain appetite, the Lp rats.

A further complication could be this: To further stress the system, by exposure from fetal life to adulthood, rat dams of the outbreed Sprague–Dawley stock were mated and fed with a high-energy-dense diet (HEDD) and bacterial supplement during pregnancy and lactation, and then their offspring received the same treatment for 6 months.

Changes in parents' phenotypes due to environmental factors can manifest in differences in offspring in different ways and even have effects on succeeding and future generations, aka epigenetics.
38 posted on 05/26/2011 3:56:31 PM PDT by aruanan
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