Click here: to donate by Credit Card
Or here: to donate by PayPal
Or by mail to: Free Republic, LLC - PO Box 9771 - Fresno, CA 93794
Thank you very much and God bless you.
Posted on 07/15/2025 10:45:44 AM PDT by Red Badger
A major new study reveals that combining the weight-loss drug tirzepatide with menopause hormone therapy leads to significantly greater fat loss in postmenopausal women.
Women using both therapies saw an average weight loss of 17%—compared to just 14% with tirzepatide alone—and were more than twice as likely to lose 20% or more of their body weight.
Tirzepatide Plus Hormone Therapy Boosts Weight Loss in Postmenopausal Women
Using tirzepatide and menopause hormone therapy at the same time leads to increased weight loss in postmenopausal women with overweight or obesity compared to use of tirzepatide treatment alone, according to a study being presented Saturday at ENDO 2025, the Endocrine Society’s annual meeting in San Francisco, Calif.
“These data are the first to show the combined use of tirzepatide and menopause hormone therapy significantly increases treatment effectiveness in postmenopausal women,” said Regina Castaneda, M.D., research fellow for the Division of Endocrinology at the Mayo Clinic in Jacksonville, Fla. “Previous studies of the medication semaglutide found similar results. Achieving these outcomes with a second obesity medication may indicate a broader efficacy trend for pairing these two classes of medications.”
Why Menopause Makes Weight Loss Harder
Menopause-related hormonal changes often result in increased abdominal fat, decreased muscle mass, and altered energy expenditure that leads to weight gain and puts millions of women at risk for developing heart disease and other serious health issues.
To confirm the hypothesis that concurrent menopause hormone therapy enhances the effectiveness of tirzepatide for weight loss in postmenopausal women, researchers conducted a real-world study using the electronic medical records of 120 postmenopausal women over a median duration of 18 months. The study included two cohorts: 40 women using menopause hormone therapy concurrently with tirzepatide and 80 women using tirzepatide alone.
Superior Results From Dual Treatment Strategy
The results showed superior total body weight loss percentage for women using tirzepatide plus menopause hormone therapy (17%) compared to those using tirzepatide alone (14%). In addition, a higher percentage of menopause hormone therapy users (45%) also achieved at least 20% total body weight loss, compared to 18% of menopause hormone therapy non-users.
Call for More Research and Better Access
“The information garnered through this new study provides important insights to develop more effective and personalized weight management interventions to reduce a postmenopausal woman’s risk of overweight and obesity-related health complications,” said Maria Daniela Hurtado Andrade, M.D., Ph.D., assistant professor of medicine and consultant for the Division of Endocrinology at the Mayo Clinic.
“This study underscores the urgent need for further research to better understand how obesity medications and menopause hormone therapy work together. Gaining this knowledge could greatly improve the health and well-being of millions of postmenopausal women. It also points to the need for better strategies to make these treatments more accessible and available to those who need them.”
This research was funded by the National Institutes of Health Bridging Interdisciplinary Careers in Women’s Health Research Grant and the Mayo Clinic Center for Women’s Health Research.
|
|
Click here: to donate by Credit Card Or here: to donate by PayPal Or by mail to: Free Republic, LLC - PO Box 9771 - Fresno, CA 93794 Thank you very much and God bless you. |
Additional weight, just adds complications to health, and shortens life. Helping a motivated person lose weight, so that they can become mobile enough (and wise enough to moderate their diet) to keep it off - is a good thing.
Cigarettes and speed?
These new GLP-1 drugs are a real game-changer - the first real cure for America’s obesity epidemic. Given how many people are on Medicare and receiving medical treatment on the taxpayer’s dime for obesity-related illnesses, the government should be subsidizing GLP-1 drugs for every obese person who wants it. It’d save the taxpayer billions annually.
Terzepitide alone works great. I can’t afford it anymore, but I would never take hormone replacement therapy. Too many adverse effects.
“Cigarettes and speed?”
1970’s-80’s classic. Ages like fine wine.
My late father in law made a comment that still makes me smile. In essence he said that a man wants his wife to maintain her looks and weight. But after they get married all these women get fat, and when they get older, THEN they worry about their weight. He wasn’t wrong.
yep. i got breast cancer stage 1 from HRT. I’m doing fasting 3 days a week for now.
Oh, LORD, please heal my FReeper sister I pray in Jesus Name!
Do you fast three consecutive days, or alternate days? I’ve heard of people fasting for very long periods at a time, and it seems impossible.
Drugs for everything..the American way. Eat right, exercise and no problem. Doesn’t require any drugs but a good beer or whiskey helps.
Not eating but little is far better.
consecutive
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.