Posted on 07/14/2025 9:35:21 AM PDT by SeekAndFind
Losing a tooth is an important developmental stage in childhood, but it is far less pleasant in adulthood. It needs pricey dental substitutes like dentures or implants, but that could soon change. Toregem Biopharma, a Japanese pharmaceutical business, is about to launch a ground-breaking medication designed to promote tooth growth.
The Japan Times claims that the group responsible for this outstanding accomplishment, which was supported by Kyoto University and headed by Toregem Biopharma, had been working hard on the project for years. A medication that targets the suppression of a protein that inhibits tooth growth is the result of their work.
Dr. Katsu Takahashi, a renowned researcher and the head of the dentistry and oral surgery department at the prestigious Medical Research Institute Kitano Hospital, is at the forefront of this medical advancement. When Dr. Takahashi started doing intensive study at Kyoto University in 2005, he began his relentless quest for the regrowth of teeth, an apparently unattainable ambition.
Their ground-breaking discovery is based on a particular mouse gene called USAG-1, which has a significant impact on how teeth form. The dual function of the gene, which may either stimulate or inhibit dental growth, was discovered by the researchers. The crucial concept that surfaced was the development of a "neutralizing antibody medicine" intended to successfully prevent the negative consequences of the USAG-1 gene, thereby opening the door for tooth regrowth.
The scientific community was shocked by the hopeful results of the first trials on mice, which showed that the new medication caused the creation of new teeth. But the researchers wasn't satisfied with their success; they wanted to confirm their findings on ferrets, whose tooth patterns closely resembled those of humans. The experimental medication caused amazing tooth regeneration in the ferrets. It was a turning point in their quest...
(Excerpt) Read more at msn.com ...
YOU CAN’T HANDLE THE TOOTH!
Human trials started September 2024.
If all goes well, they hope to bring the drug to market by 2030 and usher in a time when people with oral problems can finally smile again.
The only downside is that the tooth grows out of the end of your nose...
The side effects in some should be...interesting.
I think that you win the thread.
First Chuckle of my day (-:
At 70?.................
Many years ago (1966) I saw a young man with teeth growing out of his ear.
Google AI says: Diprosopus (Craniofacial Duplication)
Maybe this could be the beginning of regeneration of other body parts.
I hate MSN. Here’s the original article if you had taken the time to find it.
Related...
Japanese researchers test pioneering drug to regrow teeth
13DEC2024
https://medicalxpress.com/news/2024-12-japanese-drug-regrow-teeth.html
Humans May Be Able to Grow New Teeth Within Just 5 Years
15MAR2025
https://www.popularmechanics.com/science/health/a64188957/human-tooth-regrowth-trials-japan/
Growing a Third Set of Teeth: How Japan’s Groundbreaking Drug Could Revolutionize Dentistry
14APR2025
https://www.crownanddenturesolutions.com/post/tooth-regrowth-drug-japan-dentistry
“Their ground-breaking discovery is based on a particular mouse gene called USAG-1”
Gene therapy? NO WAY!
Let’s hope it cheaper than implants, although implants, while expensive, do work well.
What if you want a new front tooth and what grows is a molar?
USAG-1... Usagi. “Rabbit” in Japanese.
I am really put off by the long list of side effects rolled out in every pharmceutical ad on TV.
I had a friend who was on some kind of drug for osteoporosis, and began to have problems in her jaw.
Interesting and at the same time kind of scary. I can imagine teeth growing where they are not supposed to grow, and as yet unknown side effects. Seems like all of the newer drugs have some nasty side effects.
Possible side effects include a third eye, fish gills, and if your mouth returns to a full set of teeth, a predilection to talk like Jimmy Carter.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.