Posted on 03/30/2025 7:18:10 AM PDT by ConservativeMind
The largest analysis to examine the best way to lower levels of "bad" cholesterol in patients with blocked arteries shows that they should immediately be given a combination of a statin and another drug called ezetimibe, rather than statins alone. This could prevent thousands of deaths a year from heart attacks, strokes and other cardiovascular diseases.
The meta-analysis of 108,353 patients in 14 studies who were at very high risk of suffering heart attack or stroke, or who had already suffered one of these cardiovascular events shows that when ezetimibe was combined with a high dose statin to reduce levels of LDL-C, there was a significant 19% reduction in the risk of death from any cause, a 16% reduction in deaths from cardiovascular causes, and a significant reduction in the incidence of major adverse cardiovascular events or stroke by 18% and 17% respectively, compared to high doses of statins alone.
The combination therapy also significantly reduced LDL-C levels by an extra 13mg per deciliter (dL) of blood compared to statins alone, measured from the time the patient first started the treatment. This increased the chances of reaching the ideal goal of less than 70mg/dL of LDL-C by 85%.
"These results were even more pronounced in the network meta-analysis, which enables a direct comparison of different therapy regimens used in the study. This showed a 49% reduction in all-cause mortality and a 39% reduction in major adverse cardiovascular events, when compared to high-dose statin therapy alone," said Maciej Banach,
"The combination therapy is safe and efficacious; the risk of adverse events and the therapy discontinuation rate was comparable between groups. In the network meta-analysis, we showed a significant 44% reduction in the risk of discontinuation in those treated with moderately high-dose statin therapy plus ezetimibe versus a high-dose statin alone."
(Excerpt) Read more at medicalxpress.com ...
You are still gonna die, and statins make your legs weak and crampy.
Most. I’m a hospice nurse.
I recently learned that some statins are hydrophilic, while others are lipophilic. If you have a particular statin concern, you might want to look up the difference.
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“...he won’t quit statins because the doctor has convinced him he will die immediately if he does.”
I stopped statins cold turkey and was back to normal within a week.
BKMRK.
Doc prescribed Atorvastatin for me. Two weeks of every muscle and joint in my body hurting. No more, I chew up a baby aspirin every morning. I hope it helps people, but that stuff was poison in my body.
bkmk
I have read that statins can cause liver problems as evidenced by elevated levels of enzymes ALT and AST.
The entire cholesterol hoax is bull crap but a massive money maker for big pharma.
I will take early death, thanks. Besides which, living with Alzheimers is just a waking death. You are not really “living”. You are dying? If I am going to be in a persistent dying state with zero quality of life, I would sooner just have the real thing — early death.
Nattozymes, or nattokinase, reduces fibrin. I take a small dose every morning on an empty stomach. A larger dose, too close to breakfast, messes up my digestion.
An argument, for why women tend to live longer than men, is that menstration clears out a lot of fibrin. Men and post-menopausal women might choose to take nattokinase. If you are already on a blood thinner, that further complicates matters.
No such thing as bad cholesterol. They’ve lied to us about cholesterol for many decades. Cholesterol has nothing, zero to do with plaque and clogged arteries. Insulin resistance causes it. Statins, the most prescribed drug, are horrible, leading cause of dementia. Much new research is being done in this area. The big cholesterol lie started with Eisenhower’s heart attack, which spawned the Framingham study. Healthy people should have very high cholesterol. I’ve been on the carnivore diet for 2 years now, and my cholesterol is through the roof. Doctors are almost ALL quacks who want us all on statins.
Those numbers are similar to mine. They’ve been consistently high ever since my 20’s. I use No seed oil, use butter, tallow or bacon fat to cook. I do not tolerate statins well, even omega 3 will make my bones ache. I did have an aortic valve replaced 18 months ago, likely genetic. When they did the cath prior to the TAVR they said I had no blockages...go figure.
Several treatment guidelines recommend adding ezetimibe in select high risk persons in whom LDL goals cannot be achieved by maximally tolerated statin alone.
https://en.wikipedia.org/wiki/Ezetimibe
Do you mean in natural form (fish) or manufactured/processed (supplement) form?
Oh, what the hell..I’ve made it to 80 - maybe this’ll help me make it to 81.
‘We’re living proof that the stuff works’
I, like many super healthy carnivores, have VLDLs in the 500 (lean mass hyper responders). According to the drug dealers in the medical establishment, we should all drop dead already. So we are the real living proof that the cholesterol scare and the statins push are all the same scam.
BTW, fun fact, high triglycerides is as correlated to coronary heart diseases as VLDL, if not more according to professor Robert Lustig, just much less studied. Yet no pill has been pushed to reduce them, do you know why? Because big pharmas never found it, all they found, by accident, is statin, a class of molecules so toxic in animals trials that the Japanese company which found it never put it on the market. Its initial discoverer, Akira Endo refuses to take it when prescribed by his doctor. The guy must know what big pharmas mean when they say “safe and effective”.
“I’ve been on the carnivore diet for 2 years now”
Lovasa....obviously big pharma.
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