Posted on 11/25/2024 1:13:45 PM PST by nickcarraway
Needle-free nano-vaccine, cheap to produce, requires no refrigeration and is administered as nasal spray, making it accessible to developing nations.y
A pair of scientists from Israel and Portugal have developed an inexpensive and effective new nano-vaccine against Covid-19, which can be stored at room temperature and administered as a nasal spray.
The breakthrough vaccine trains the immune system against all common Covid-19 variants with the same efficiency as existing vaccines.
But it does not require an injection or a cold supply chain and cold storage, making it ideal for vaccinating at-risk populations in developing countries and in remote regions.
In addition, the scientists believe it paves the way to the development of simpler, more effective, and less expensive vaccines in the future.
Prof. Ronit Satchi-Fainaro from Tel Aviv University’s Faculty of Medical and Health Sciences developed the vaccine in collaboration with Prof. Helena Florindo at the University of Lisbon.
“The new nano-vaccine’s development was inspired by a decade of research on cancer vaccines,” said Satchi-Fainaro. “When the Covid-19 pandemic began, we set a new goal: training our cancer platform to identify and target the coronavirus.”
Satchi-Fainaro said the researchers did not rely on full protein expression via mRNA, unlike the Moderna and Pfizer Covid vaccines.
“Instead, using our computational bioinformatics tools, we identified two short and simple amino acid sequences in the virus’s protein, then synthesized them, and encapsulated them in nanoparticles.”
“Our nano-vaccine offers a significant advantage over existing vaccines because it is needle-free and administered as a nasal spray,” said Satchi-Fainaro.
“This eliminates the need for skilled personnel such as nurses and technicians to administer injections, while also reducing risks of contamination and sharps [biohazardous] waste. Anyone can use a nasal spray, with no prior training.”
Stored as powder, as effective as Pfizer
Another major advantage of the nano-vaccine is its minimal storage requirements.
Moderna’s sensitive mRNA-based vaccine must be kept at -20°C and Pfizer’s at -70°C, generating great logistic and technological challenges, such as shipping in special aircraft and ultra-cold storage from the factory to the vaccination station.
The synthetic nanoparticles are far more durable and can be stored as a powder at room temperature.
“There’s no need for freezing or special handling,” said Satchi-Fainaro. “You just mix the powder with saline to create the spray. For testing purposes [as part of the EU’s ISIDORe Integrated Services for Infectious Disease Outbreak Research feasibility program] we shipped the powder at room temperature to the INSERM infectious diseases lab in France. Their tests showed that our nano-vaccine is at least as effective as Pfizer’s vaccine.”
Aside from its value to developing countries, Satchi-Fainaro said the plug-and-play technology provides a platform enabling scientists to synthesize more effective and affordable vaccines for future pandemics.
“[The technology] can train the immune system to fight cancer or infectious diseases like Covid-19. We are currently expanding its use to target a range of additional diseases, enabling the rapid development of relevant new vaccines when needed,” she said.
The research has received grants from the Israel Innovation Authority and Merck under the Nofar program, as well as funding from Spain’s La Caixa Foundation Impulse as an accelerated program, and support from the ISIDORe feasibility program.
It is also part of a broader vaccine platform development program at Satchi-Fainaro’s lab, supported by a European Research Council Advanced Grant.
Give it to Fauci
Still won’t get it
No. Just no.
I don’t get yearly flu shots. I didn’t take any covid shots. I am, however, a grateful recipient of the polio vaccine and none of the assorted childhood shots in the late 50’s seem to have done me any harm. If I traveled, I’d take various shots as required. I’m not opposed to all inoculation, but I’m not a guinea pig.
You ever notice a sudden accumulation on the vehicles dashboard? shelves
Still an mRNA-based spike protein producer?
The rolling ladder is in the library with the 10 ft ceiling. I just pretend the top shelves in the hallway aren’t dusty. There is more dust in the car but I’m in it so seldom that it doesn’t make a big impression on me. I decorate walls and furniture with mirrors so the dust really shows in the house. Even when I was creating the library, with all the associated wood sanding, I never had as much trouble with dust as I have had over the last couple years.
When I watch Chinese dramas, there’s no view out the windows of high rises. Reading up, articles blame it on dust particles in the air. Followed that up with reading about paths of the Chinese dust migrating around the world on wind currents. I’ve sort of thought that’s what we might be dealing with, then let the thought escape.
Have a nice day now.
There is always a bunch of dust.
Awesome... So a vaccine that doesn’t work, but you can spray it up your nose... This will be very good for those poor people who’ve been getting a jab for every updated Covid vaccine that doesn’t work.
“Are the nano-particles as unnecessarily invasive, more unnecessarily invasive or less unnecessrily invasive than the mRNA sequences in the other Covid vaccines??”
A peptide-based approach is much more selective and specific than the whole-spike-protein used in most current C19 vaccines.
I would consider this depending on the results of phase trials.
Why use a nuke when you can use a small delivery vehicle that gets about the same results?
That’s a HUGE NO!
Can’t believe they’re still trying to push this carp...welll, yes, I can.
For a freaking @$$ cold.
They’re pining for those fear funds and mandate bucks.
Oops ... meant to ping you to 54 ... fear fund and mandate bucks, is right on.
So, they can just pump vaccines into the air we breath...’vaccine hesitancy’ solved.
great they’ll probably spray it around places without telling any one.
Its advanced technology kills the undesirables before they even receive the injection...
Saves lots & lots of medical costs...
The government, and the drug companies it finances, continues in its Herculean efforts to cull the herd...
Wait, what?
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